Publications from TNU

Abildgaard, A., Kern, T., Pedersen, O., Hansen, T., Lund, S. & Wegener, G. (2021). A diet-induced gut microbiota component and related plasma metabolites are associated with depressive-like behaviour in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 43, 10-21. https://doi.org/10.1016/j.euroneuro.2020.09.001

Al-Absi, A-R., Qvist, P., Glerup, S., Sanchez, C. & Nyengaard, J. R. (2021). Df(h15q13)/+ Mouse Model Reveals Loss of Astrocytes and Synaptic-Related Changes of the Excitatory and Inhibitory Circuits in the Medial Prefrontal Cortex. Cerebral Cortex, 31(3), 1609-1621. https://doi.org/10.1093/cercor/bhaa313

Binda, K. H., Lillethorup, T. P., Real, C. C., Bærentzen, S. L., Nielsen, M. N., Orlowski, D., Brooks, D. J., Chacur, M. & Landau, A. M. (2021). Exercise protects synaptic density in a rat model of Parkinson's disease. Experimental Neurology, 113741. https://doi.org/10.1016/j.expneurol.2021.113741

Chen, F., Danladi, J., Ardalan, M., Nyengaard, J. R., Sánchez, C. & Wegener, G. (2021). The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine. European Neuropsychopharmacology, 42, 45-56. https://doi.org/10.1016/j.euroneuro.2020.11.008

Jefsen, O. H., Elfving, B., Wegener, G. & Müller, H. K. (2021). Transcriptional regulation in the rat prefrontal cortex and hippocampus after a single administration of psilocybin. Journal of Psychopharmacology, 35(4), 483-493. https://doi.org/10.1177/0269881120959614

Kaadt, E., Højgaard, K., Mumm, B., Christiansen, S. L., Müller, H. K., Damgaard, C. K. & Elfving, B. (2021). Dysregulation of miR-185, miR-193a, and miR-450a in the skin are linked to the depressive phenotype. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 104, [110052]. https://doi.org/10.1016/j.pnpbp.2020.110052

Kuebler, L., Buss, S., Leonov, A., Ryazanov, S., Schmidt, F., Maurer, A., Weckbecker, D., Landau, A. M., Lillethorup, T. P., Bleher, D., Saw, R. S., Pichler, B. J., Griesinger, C., Giese, A. & Herfert, K. (2021). [¹¹C]MODAG-001-towards a PET tracer targeting α-synuclein aggregates. European Journal of Nuclear Medicine and Molecular Imaging, 48(6), 1759–1772 . https://doi.org/10.1007/s00259-020-05133-x

Mansouri, M., Pouretemad, H., Wegener, G., Roghani, M., Afshari, M., Mallard, C. & Ardalan, M. (2021). Dual Profile of Environmental Enrichment and Autistic-Like Behaviors in the Maternal Separated Model in Rats. International Journal of Molecular Sciences, 22(3), [1173]. https://doi.org/10.3390/ijms22031173

Martis, L-S., Højgaard, K., Holmes, M. C., Elfving, B. & Wiborg, O. (2021). Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task. Scientific Reports, 11(1), 9113. https://doi.org/10.1038/s41598-021-88462-7

Orso, R., Creutzberg, K. C., Lumertz, F. S., Wearick-Silva, L. E., Sanches, E. F., Mestriner, R. G., Wegener, G. & Grassi-Oliveira, R. (2021). Early environmental enrichment rescues memory impairments provoked by mild neonatal hypoxia-ischemia in adolescent mice. Behavioural Brain Research, 407, [113237]. https://doi.org/10.1016/j.bbr.2021.113237

Sales, A. J., Maciel, I. S., Suavinha, A. C. D. R. & Joca, S. R. L. (2021). Modulation of DNA Methylation and Gene Expression in Rodent Cortical Neuroplasticity Pathways Exerts Rapid Antidepressant-Like Effects. Molecular Neurobiology, 58(2), 777–794. https://doi.org/10.1007/s12035-020-02145-4

Silveira, K. M., Wegener, G. & Joca, S. R. L. (2021). Targeting 2-arachidonoylglycerol (2-AG) signalling the neurobiology and treatment of depression. Basic & Clinical Pharmacology & Toxicology. https://doi.org/10.1111/bcpt.13595

Smedegaard, S. B., Mose, M., Hulman, A., Mikkelsen, U. R., Møller, N., Wegener, G., Jessen, N. & Rittig, N. (2021). β-Lactoglobulin Elevates Insulin and Glucagon Concentrations Compared with Whey Protein-A Randomized Double-Blinded Crossover Trial in Patients with Type Two Diabetes Mellitus. Nutrients, 13(2), [308]. https://doi.org/10.3390/nu13020308

Terstege, D. J., MacDonald, D. S. & Tasker, R. A. (2021). Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test. Acta Neuropsychiatrica, 33(3), 141-147. https://doi.org/10.1017/neu.2021.2

Thomsen, M., Jacobsen, J., Lillethorup, T. P., Schacht, A. C., Simonsen, M. I. T., Romero-Ramos, M., Brooks, D. J. & Landau, A. (2021). In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET. Journal of Cerebral Blood Flow and Metabolism, 41(4), 819-830. https://doi.org/10.1177/0271678X20931140

Thomsen, M. B., Ferreira, S. A., Schacht, A. C., Jacobsen, J., Simonsen, M., Betzer, C., Jensen, P. H., Brooks, D. J., Landau, A. M. & Romero-Ramos, M. (2021). PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats. Neurobiology of Disease, 149, [105229]. https://doi.org/10.1016/j.nbd.2020.105229

Tillmann, S., Awwad, H. M., MacPherson, C. W., Happ, D. F., Treccani, G., Geisel, J., Tompkins, T. A., Ueland, P. M., Wegener, G. & Obeid, R. (2021). The kynurenine pathway is upregulated by methyl-deficient diet and changes are averted by probiotics. Molecular Nutrition & Food Research, e2100078. https://doi.org/10.1002/mnfr.202100078

Tondo, L. P., Viola, T. W., Fries, G. R., Kluwe-Schiavon, B., Rothmann, L. M., Cupertino, R., Ferreira, P., Franco, A. R., Lane, S. D., Stertz, L., Zhao, Z., Hu, R., Meyer, T., Schmitz, J. M., Walss-Bass, C. & Grassi-Oliveira, R. (2021). White matter deficits in cocaine use disorder: convergent evidence from in vivo diffusion tensor imaging and ex vivo proteomic analysis. Translational Psychiatry, 11(1), [252]. https://doi.org/10.1038/s41398-021-01367-x

Treccani, G., Yigit, H., Lingner, T., Schleuβner, V., Mey, F., van der Kooij, M. A., Wennström, M., Herzog, D. P., Linke, M., Fricke, M., Schmeisser, M. J., Wegener, G., Mittmann, T., Trotter, J. & Müller, M. B. (2021). Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Na_v) channels properties. Neurobiology of Stress, 15, [100338]. https://doi.org/10.1016/j.ynstr.2021.100338

Treccani, G., Schlegelmilch, A. L., Schultz, N., Herzog, D. P., Bessa, J. M., Sotiropoulos, I., Müller, M. B. & Wennström, M. (2021). Hippocampal NG2+ pericytes in chronically stressed rats and depressed patients: a quantitative study. Stress, 24(3), 353-358. https://doi.org/10.1080/10253890.2020.1781083

Vibholm, A. K., Landau, A. M., Møller, A., Jacobsen, J., Vang, K., Munk, O. L., Orlowski, D., Sorensen, J. C. H. & Brooks, D. J. (2021). NMDA receptor ion channel activation detected in vivo with [¹⁸F]GE-179 PET after electrical stimulation of rat hippocampus. Journal of Cerebral Blood Flow and Metabolism, 41(6), 1301-1312. https://doi.org/10.1177/0271678X20954928

Al-Absi, A-R., Qvist, P., Okujeni, S., Khan, A. R., Glerup, S., Sanchez, C. & Nyengaard, J. R. (2020). Layers II/III of Prefrontal Cortex in Df(h22q11)/+ Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability. Molecular Neurobiology, 57(12), 4978–4988 . https://doi.org/10.1007/s12035-020-02067-1

Ardalan, M., Elfving, B., Rafati, A. H., Mansouri, M., Zarate, C. A., Mathe, A. A. & Wegener, G. (2020). Rapid effects of S-ketamine on the morphology of hippocampal astrocytes and BDNF serum levels in a sex-dependent manner. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 32, 94-103. https://doi.org/10.1016/j.euroneuro.2020.01.001

Bay, V., Happ, D. F., Ardalan, M., Quist, A., Oggiano, F., Chumak, T., Hansen, K., Ding, M., Mallard, C., Tasker, R. A. & Wegener, G. (2020). Flinders sensitive line rats are resistant to infarction following transient occlusion of the middle cerebral artery. Brain Research, 1737, [146797]. https://doi.org/10.1016/j.brainres.2020.146797

Berntsen, H. F., Moldes-Anaya, A., Bjørklund, C. G., Ragazzi, L., Haug, T. M., Strandabø, R. A. U., Verhaegen, S., Paulsen, R. E., Ropstad, E. & Tasker, R. A. (2020). Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons. Toxicology, 445, [152610]. https://doi.org/10.1016/j.tox.2020.152610

Bukowski, L., Chernomorchenko, A. M. F., Starnawska, A., Mors, O., Staunstrup, N. H., Børglum, A. D. & Qvist, P. (2020). Neuropsin in mental health. Journal of Physiological Sciences, 70(1), [26]. https://doi.org/10.1186/s12576-020-00753-2

Butler, H. M., Naseri, E., MacDonald, D. S., Andrew Tasker, R. & Ahmadi, A. (2020). Optimization of starch- and chitosan-based bio-inks for 3D bioprinting of scaffolds for neural cell growth. Materialia, 12, [100737]. https://doi.org/10.1016/j.mtla.2020.100737

Chen, F., Bertelsen, A. B., Holm, I. E., Nyengaard, J. R., Rosenberg, R. & Dorph-Petersen, K. A. (2020). Hippocampal volume and cell number in depression, schizophrenia, and suicide subjects. Brain Research, 1727, [146546]. https://doi.org/10.1016/j.brainres.2019.146546

Chen, F., Polsinelli, B., Nava, N., Treccani, G., Elfving, B., Müller, H. K., Musazzi, L., Popoli, M., Nyengaard, J. R. & Wegener, G. (2020). Structural Plasticity and Molecular Markers in Hippocampus of Male Rats after Acute Stress. Neuroscience, 438, 100-115. https://doi.org/10.1016/j.neuroscience.2020.05.001

Chen, F., Danladi, J., Wegener, G., Madsen, T. M. & Nyengaard, J. R. (2020). Sustained Ultrastructural Changes in Rat Hippocampal Formation After Repeated Electroconvulsive Seizures. The international journal of neuropsychopharmacology, 23(7), 446-458. https://doi.org/10.1093/ijnp/pyaa021

Coleman, J. R. I., Peyrot, W. J., Purves, K. L., Davis, K. A. S., Rayner, C., Choi, S. W., Hubel, C., Gaspar, H. A., Kan, C., Van der Auwera, S., Adams, M. J., Lyall, D. M., Choi, K. W., Psychiat Genomics Consortium, Dunn, E. C., Vassos, E., Danese, A., Maughan, B., Grabe, H. J. ... Breen, G. (2020). Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular Psychiatry, 25(7), 1430-1446. https://doi.org/10.1038/s41380-019-0546-6

Garforth, B., Degnbol, H., Terris, E. T., Zak, P. J. & Winterdahl, M. (2020). Elevated plasma oxytocin levels and higher satisfaction with life in young oral contraceptive users. Scientific Reports, 10(1), [8208]. https://doi.org/10.1038/s41598-020-64528-w

Happ, D. F., Wegener, G. & Tasker, R. A. (2020). Effect of ischemic lesions in medial prefrontal cortex and nucleus accumbens on affective behavior in rats. Behavioural Brain Research, 378, [112234]. https://doi.org/10.1016/j.bbr.2019.112234

Herzog, D. P., Mellema, R. M., Remmers, F., Lutz, B., Müller, M. B. & Treccani, G. (2020). Sexually dimorphic behavioral profile in a transgenic model enabling targeted recombination in active neurons in response to ketamine and (2r,6r)-hydroxynorketamine administration. International Journal of Molecular Sciences, 21(6), [2142]. https://doi.org/10.3390/ijms21062142

Hume, A. W. & Tasker, R. A. (2020). Endothelin-1-Induced Ischemic Damage and Functional Impairment Is Mediated Primarily by NR2B-Containing NMDA Receptors. Neurotoxicity Research, 37(2), 349-355. https://doi.org/10.1007/s12640-019-00138-3

Jefsen, O. H., Petersen, L. V., Bek, T. & Østergaard, S. D. (2020). Is Early Blindness Protective of Psychosis or Are We Turning a Blind Eye to the Lack of Statistical Power? Schizophrenia Bulletin, 46(6), 1335–1336. https://doi.org/10.1093/schbul/sbaa048

Landau, A. M., Noer, O., Alstrup, A. K. O., Audrain, H., Wegener, G., Gjedde, A., Doudet, D. J. & Winterdahl, M. (2020). Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain. Molecular Imaging and Biology, 22(4), 797-804. https://doi.org/10.1007/s11307-020-01476-x

Leonard, B. E. & Wegener, G. (2020). Inflammation, insulin resistance and neuroprogression in depression. Acta Neuropsychiatrica, 32(1), 1-9. https://doi.org/10.1017/neu.2019.17

Mansouri, M., Pouretemad, H., Roghani, M., Wegener, G. & Ardalan, M. (2020). Autistic-Like Behaviours and Associated Brain Structural Plasticity are Modulated by Oxytocin in Maternally Separated Rats. Behavioural Brain Research, 393, [112756]. https://doi.org/10.1016/j.bbr.2020.112756

Mathiesen, L., Bay-Richter, C., Wegener, G., Liebenberg, N. & Knudsen, L. E. (2020). Maternal stress and placental function; ex vivo placental perfusion studying cortisol, cortisone, tryptophan and serotonin. PLOS ONE, 15(6), [e0233979]. https://doi.org/10.1371/journal.pone.0233979

Miani, A., Di Bernardo, G. A., Højgaard, A. D., Earp, B. D., Zak, P. J., Landau, A. M., Hoppe, J. & Winterdahl, M. (2020). Neonatal male circumcision is associated with altered adult socio-affective processing. Heliyon, 6(11), [e05566]. https://doi.org/10.1016/j.heliyon.2020.e05566

Okuda, K., Højgaard, K., Privitera, L., Bayraktar, G. & Takeuchi, T. (2020). Initial memory consolidation and the synaptic tagging and capture hypothesis. The European journal of neuroscience. https://doi.org/10.1111/ejn.14902

Puryear, C. B., Brooks, J., Tan, L., Smith, K., Li, Y., Cunningham, J., Todtenkopf, M. S., Dean, R. L. & Sanchez, C. (2020). Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data? Neuroscience and Biobehavioral Reviews, 108, 658-678. https://doi.org/10.1016/j.neubiorev.2019.12.007

Rajkumar, A. P., Qvist, P., Donskov, J. G., Lazarus, R., Pallesen, J., Nava, N., Winther, G., Liebenberg, N., Cour, S. H. L., Paternoster, V., Fryland, T., Palmfeldt, J., Fejgin, K., Mørk, A., Nyegaard, M., Pakkenberg, B., Didriksen, M., Nyengaard, J. R., Wegener, G. ... Børglum, A. D. (2020). Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice. Translational Psychiatry, 10, [239]. https://doi.org/10.1038/s41398-020-00914-2

Rasmussen, L. D., Bøttcher, M., Ivarsen, P., Jørgensen, H. S., Nyegaard, M., Buttenschøn, H., Gustafsen, C., Glerup, S., Bøtker, H. E., Svensson, M. & Winther, S. (2020). Association between circulating proprotein convertase subtilisin/kexin type 9 levels and prognosis in patients with severe chronic kidney disease. Nephrology, Dialysis, Transplantation, 35(4), 632-639. [gfy257]. https://doi.org/10.1093/ndt/gfy257

Riga, M. S., Sanchez, C., Celada, P. & Artigas, F. (2020). Sub-chronic vortioxetine (but not escitalopram) normalizes brain rhythm alterations and memory deficits induced by serotonin depletion in rats. Neuropharmacology, 178, [108238]. https://doi.org/10.1016/j.neuropharm.2020.108238