Publications from TNU

Abildgaard, A., Kern, T., Pedersen, O., Hansen, T., Lund, S. & Wegener, G. (2021). A diet-induced gut microbiota component and related plasma metabolites are associated with depressive-like behaviour in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 43, 10-21. https://doi.org/10.1016/j.euroneuro.2020.09.001

Al-Absi, A-R., Qvist, P., Glerup, S., Sanchez, C. & Nyengaard, J. R. (2021). Df(h15q13)/+ Mouse Model Reveals Loss of Astrocytes and Synaptic-Related Changes of the Excitatory and Inhibitory Circuits in the Medial Prefrontal Cortex. Cerebral Cortex, 31(3), 1609-1621. https://doi.org/10.1093/cercor/bhaa313

Baptista, T., de Azeredo, L. A., Zaparte, A., Viola, T. W., Coral, S. C., Nagai, M. A., Mangone, F. R., Pavanelli, A. C., Schuch, J. B., Mardini, V., Szobot, C. M. & Grassi-Oliveira, R. (2021). Oxytocin Receptor Exon III Methylation in the Umbilical Cord Blood of Newborns With Prenatal Exposure to Crack Cocaine. Frontiers in Cell and Developmental Biology, 9, [639287]. https://doi.org/10.3389/fcell.2021.639287

Bayraktar, G., Højgaard, K., Nijssen, L. & Takeuchi, T. (2021). A within-subject experimental design using an object location task in rats. Journal of Visualized Experiments, 2021(171), [e62458]. https://doi.org/10.3791/62458

Binda, K. H., Lillethorup, T. P., Real, C. C., Bærentzen, S. L., Nielsen, M. N., Orlowski, D., Brooks, D. J., Chacur, M. & Landau, A. M. (2021). Exercise protects synaptic density in a rat model of Parkinson's disease. Experimental Neurology, 342, 113741. https://doi.org/10.1016/j.expneurol.2021.113741

Butler, H. M., Naseri, E., MacDonald, D. S., Tasker, R. A. & Ahmadi, A. (2021). Investigation of rheology, printability, and biocompatibility of N,O-carboxymethyl chitosan and agarose bioinks for 3D bioprinting of neuron cells. Materialia, 18, [101169]. https://doi.org/10.1016/j.mtla.2021.101169

Chang, N. H. S., Kumakura, Y., Møller, A., Linnet, J., Bender, D., Doudet, D. J., Vafaee, M. S. & Gjedde, A. (2021). On the learning of addictive behavior: Sensation-seeking propensity predicts dopamine turnover in dorsal striatum. Brain Imaging and Behavior. https://doi.org/10.1007/s11682-021-00509-5

Chen, F., Danladi, J., Ardalan, M., Nyengaard, J. R., Sánchez, C. & Wegener, G. (2021). The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine. European Neuropsychopharmacology, 42, 45-56. https://doi.org/10.1016/j.euroneuro.2020.11.008

Dalby, R. B., Eskildsen, S. F., Videbech, P., Rosenberg, R. & Østergaard, L. (2021). Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder. Psychiatry Research - Neuroimaging, 317, [111383]. https://doi.org/10.1016/j.pscychresns.2021.111383

Faber, J., Eldrup, E., Selmer, C., Pichat, C., Hecquet, S. K., Watt, T., Kreiner, S., Karpatschof, B., Gyntelberg, F., Ballegaard, S. & Gjedde, A. (2021). Reduction of Pressure Pain Sensitivity as Novel Non-pharmacological Therapeutic Approach to Type 2 Diabetes: A Randomized Trial. Frontiers in Neuroscience, 15, [613858]. https://doi.org/10.3389/fnins.2021.613858

Happ, D. F., Wegener, G. & Tasker, R. A. (2021). Behavioral and histopathological consequences of transient ischemic stroke in the Flinders Sensitive Line rat, a genetic animal model of depression. Brain Research, 1771, [147648]. https://doi.org/10.1016/j.brainres.2021.147648

Henriksen, O. M., Gjedde, A., Vang, K., Law, I., Aanerud, J. & Rostrup, E. (2021). Regional and interindividual relationships between cerebral perfusion and oxygen metabolism. Journal of applied physiology (Bethesda, Md. : 1985), 130(6), 1836-1847. https://doi.org/10.1152/japplphysiol.00939.2020

Jefsen, O. H., Elfving, B., Wegener, G. & Müller, H. K. (2021). Transcriptional regulation in the rat prefrontal cortex and hippocampus after a single administration of psilocybin. Journal of Psychopharmacology, 35(4), 483-493. https://doi.org/10.1177/0269881120959614

Kaadt, E., Højgaard, K., Mumm, B., Christiansen, S. L., Müller, H. K., Damgaard, C. K. & Elfving, B. (2021). Dysregulation of miR-185, miR-193a, and miR-450a in the skin are linked to the depressive phenotype. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 104, [110052]. https://doi.org/10.1016/j.pnpbp.2020.110052

Khodaii, J., Araj-Khodaei, M., Vafaee, M. S., Wong, D. F. & Gjedde, A. (2021). Relative strengths of three linearizations of receptor availability: Saturation, Inhibition, and Occupancy plots. Journal of Nuclear Medicine. https://doi.org/10.2967/jnumed.117.204453

Kuebler, L., Buss, S., Leonov, A., Ryazanov, S., Schmidt, F., Maurer, A., Weckbecker, D., Landau, A. M., Lillethorup, T. P., Bleher, D., Saw, R. S., Pichler, B. J., Griesinger, C., Giese, A. & Herfert, K. (2021). [¹¹C]MODAG-001-towards a PET tracer targeting α-synuclein aggregates. European Journal of Nuclear Medicine and Molecular Imaging, 48(6), 1759–1772 . https://doi.org/10.1007/s00259-020-05133-x

Majdi, A., Sadigh-Eteghad, S. & Gjedde, A. (2021). Effects of transdermal nicotine delivery on cognitive outcomes: A meta-analysis. Acta Neurologica Scandinavica, 144(2), 179-191. https://doi.org/10.1111/ane.13436

Mansouri, M., Pouretemad, H., Wegener, G., Roghani, M., Afshari, M., Mallard, C. & Ardalan, M. (2021). Dual Profile of Environmental Enrichment and Autistic-Like Behaviors in the Maternal Separated Model in Rats. International Journal of Molecular Sciences, 22(3), [1173]. https://doi.org/10.3390/ijms22031173

Marchisella, F., Creutzberg, K. C., Begni, V., Sanson, A., Wearick-Silva, L. E., Tractenberg, S. G., Orso, R., Kestering-Ferreira, É., Grassi-Oliveira, R. & Riva, M. A. (2021). Exposure to Prenatal Stress Is Associated With an Excitatory/Inhibitory Imbalance in Rat Prefrontal Cortex and Amygdala and an Increased Risk for Emotional Dysregulation. Frontiers in Cell and Developmental Biology, 9, [653384]. https://doi.org/10.3389/fcell.2021.653384

Martis, L-S., Højgaard, K., Holmes, M. C., Elfving, B. & Wiborg, O. (2021). Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task. Scientific Reports, 11, [9113]. https://doi.org/10.1038/s41598-021-88462-7

Nielsen, S. V., Dollerup, M. R., Bærentzen, S. L., Landau, A., Munk, O. L. & Alstrup, A. K. O. (Accepted/In press). Validation and optimization of an automatic blood sampler for preclinical positron emission tomography (PET) research in domestic pigs. Laboratory Animals.

Orso, R., Creutzberg, K. C., Lumertz, F. S., Wearick-Silva, L. E., Sanches, E. F., Mestriner, R. G., Wegener, G. & Grassi-Oliveira, R. (2021). Early environmental enrichment rescues memory impairments provoked by mild neonatal hypoxia-ischemia in adolescent mice. Behavioural Brain Research, 407, [113237]. https://doi.org/10.1016/j.bbr.2021.113237

Sales, A. J., Maciel, I. S., Suavinha, A. C. D. R. & Joca, S. R. L. (2021). Modulation of DNA Methylation and Gene Expression in Rodent Cortical Neuroplasticity Pathways Exerts Rapid Antidepressant-Like Effects. Molecular Neurobiology, 58(2), 777–794. https://doi.org/10.1007/s12035-020-02145-4

Sampaio, A. S. B., Real, C. C., Gutierrez, R. M. S., Singulani, M. P., Alouche, S. R., Britto, L. R. & Pires, R. S. (2021). Neuroplasticity induced by the retention period of a complex motor skill learning in rats. Behavioural Brain Research, 414, [113480]. https://doi.org/10.1016/j.bbr.2021.113480

Sartim, A. G., Marques, J., Silveira, K. M., Gobira, P. H., Guimarães, F. S., Wegener, G. & Joca, S. R. (2021). Co-administration of cannabidiol and ketamine induces antidepressant-like effects devoid of hyperlocomotor side-effects. Neuropharmacology, 195, [108679]. https://doi.org/10.1016/j.neuropharm.2021.108679

Schou, T. M., Joca, S., Wegener, G. & Bay-Richter, C. (2021). Psychiatric and neuropsychiatric sequelae of COVID-19 - A systematic review. Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2021.07.018

Silveira, K. M., Wegener, G. & Joca, S. R. L. (2021). Targeting 2-arachidonoylglycerol signalling in the neurobiology and treatment of depression. Basic & Clinical Pharmacology & Toxicology, 129(1), 3-14. https://doi.org/10.1111/bcpt.13595

Smedegaard, S. B., Mose, M., Hulman, A., Mikkelsen, U. R., Møller, N., Wegener, G., Jessen, N. & Rittig, N. (2021). β-Lactoglobulin Elevates Insulin and Glucagon Concentrations Compared with Whey Protein-A Randomized Double-Blinded Crossover Trial in Patients with Type Two Diabetes Mellitus. Nutrients, 13(2), [308]. https://doi.org/10.3390/nu13020308

Sävman, K., Wang, W., H.Rafati, A., Svedin, P., Nair, S., Golubinskaya, V., Ardalan, M., L Brown, K., Karlsson-Bengtsson, A. & Mallard, C. (2021). Galectin-3 modulates microglia inflammation in vitro but not neonatal brain injury in vivo under inflammatory conditions. Developmental Neuroscience.

Terstege, D. J., MacDonald, D. S. & Tasker, R. A. (2021). Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test. Acta Neuropsychiatrica, 33(3), 141-147. https://doi.org/10.1017/neu.2021.2

Thomsen, M., Jacobsen, J., Lillethorup, T. P., Schacht, A. C., Simonsen, M. I. T., Romero-Ramos, M., Brooks, D. J. & Landau, A. (2021). In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET. Journal of Cerebral Blood Flow and Metabolism, 41(4), 819-830. https://doi.org/10.1177/0271678X20931140

Thomsen, M. B., Ferreira, S. A., Schacht, A. C., Jacobsen, J., Simonsen, M., Betzer, C., Jensen, P. H., Brooks, D. J., Landau, A. M. & Romero-Ramos, M. (2021). PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats. Neurobiology of Disease, 149, [105229]. https://doi.org/10.1016/j.nbd.2020.105229

Tillmann, S., Awwad, H. M., MacPherson, C. W., Happ, D. F., Treccani, G., Geisel, J., Tompkins, T. A., Ueland, P. M., Wegener, G. & Obeid, R. (2021). The kynurenine pathway is upregulated by methyl-deficient diet and changes are averted by probiotics. Molecular Nutrition & Food Research, 65(9), e2100078. [2100078]. https://doi.org/10.1002/mnfr.202100078

Tondo, L. P., Viola, T. W., Fries, G. R., Kluwe-Schiavon, B., Rothmann, L. M., Cupertino, R., Ferreira, P., Franco, A. R., Lane, S. D., Stertz, L., Zhao, Z., Hu, R., Meyer, T., Schmitz, J. M., Walss-Bass, C. & Grassi-Oliveira, R. (2021). White matter deficits in cocaine use disorder: convergent evidence from in vivo diffusion tensor imaging and ex vivo proteomic analysis. Translational Psychiatry, 11(1), [252]. https://doi.org/10.1038/s41398-021-01367-x

Treccani, G., Yigit, H., Lingner, T., Schleuβner, V., Mey, F., van der Kooij, M. A., Wennström, M., Herzog, D. P., Linke, M., Fricke, M., Schmeisser, M. J., Wegener, G., Mittmann, T., Trotter, J. & Müller, M. B. (2021). Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Na_v) channels properties. Neurobiology of Stress, 15, [100338]. https://doi.org/10.1016/j.ynstr.2021.100338

Treccani, G., Schlegelmilch, A. L., Schultz, N., Herzog, D. P., Bessa, J. M., Sotiropoulos, I., Müller, M. B. & Wennström, M. (2021). Hippocampal NG2+ pericytes in chronically stressed rats and depressed patients: a quantitative study. Stress, 24(3), 353-358. https://doi.org/10.1080/10253890.2020.1781083

Vibholm, A. K., Landau, A. M., Møller, A., Jacobsen, J., Vang, K., Munk, O. L., Orlowski, D., Sorensen, J. C. H. & Brooks, D. J. (2021). NMDA receptor ion channel activation detected in vivo with [¹⁸F]GE-179 PET after electrical stimulation of rat hippocampus. Journal of Cerebral Blood Flow and Metabolism, 41(6), 1301-1312. https://doi.org/10.1177/0271678X20954928

Al-Absi, A-R., Qvist, P., Okujeni, S., Khan, A. R., Glerup, S., Sanchez, C. & Nyengaard, J. R. (2020). Layers II/III of Prefrontal Cortex in Df(h22q11)/+ Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability. Molecular Neurobiology, 57(12), 4978–4988 . https://doi.org/10.1007/s12035-020-02067-1

Ardalan, M., Elfving, B., Rafati, A. H., Mansouri, M., Zarate, C. A., Mathe, A. A. & Wegener, G. (2020). Rapid effects of S-ketamine on the morphology of hippocampal astrocytes and BDNF serum levels in a sex-dependent manner. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 32, 94-103. https://doi.org/10.1016/j.euroneuro.2020.01.001

Azimi , T., Nasser, A., Shariati, A., Jabbari, M., Safari, H., Alizade-Sani, M., Taghipour, A. & Dehghan, A. (2020). The Possible Role of Pathogenic and Non-Pathogenic Bacteria in Initiation and Exacerbation of Celiac Disease; A Comprehensive Review. Current Pharmaceutical Biotechnology.

Bay, V., Happ, D. F., Ardalan, M., Quist, A., Oggiano, F., Chumak, T., Hansen, K., Ding, M., Mallard, C., Tasker, R. A. & Wegener, G. (2020). Flinders sensitive line rats are resistant to infarction following transient occlusion of the middle cerebral artery. Brain Research, 1737, [146797]. https://doi.org/10.1016/j.brainres.2020.146797

Berntsen, H. F., Moldes-Anaya, A., Bjørklund, C. G., Ragazzi, L., Haug, T. M., Strandabø, R. A. U., Verhaegen, S., Paulsen, R. E., Ropstad, E. & Tasker, R. A. (2020). Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons. Toxicology, 445, [152610]. https://doi.org/10.1016/j.tox.2020.152610

Bukowski, L., Chernomorchenko, A. M. F., Starnawska, A., Mors, O., Staunstrup, N. H., Børglum, A. D. & Qvist, P. (2020). Neuropsin in mental health. Journal of Physiological Sciences, 70(1), [26]. https://doi.org/10.1186/s12576-020-00753-2

Butler, H. M., Naseri, E., MacDonald, D. S., Andrew Tasker, R. & Ahmadi, A. (2020). Optimization of starch- and chitosan-based bio-inks for 3D bioprinting of scaffolds for neural cell growth. Materialia, 12, [100737]. https://doi.org/10.1016/j.mtla.2020.100737

Chen, F., Bertelsen, A. B., Holm, I. E., Nyengaard, J. R., Rosenberg, R. & Dorph-Petersen, K. A. (2020). Hippocampal volume and cell number in depression, schizophrenia, and suicide subjects. Brain Research, 1727, [146546]. https://doi.org/10.1016/j.brainres.2019.146546