Publications from TNU

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Severinsen, K., Koldsø, H., Tran, M., Sinning, S., Jensen, H. H., Schiøtt, H. B. & Wiborg, O. (2008). Orientering af S- og R-citalopram i serotonintransporteren - Computermodeller og biokemisk validering. Poster session presented at Orientering af S- og R-citalopram i serotonintransporteren - Computermodeller og biokemisk validering, Risskov, Denmark.

Severinsen, K., Koldsø, H., T Møller, P., Schiøtt, B., Rudnick, G. & Sinning, S. (2010). Konformationsændringer i serotonintransporteren som basis for effektiv binding af antidepressiva. Poster session presented at Psykiatriens 5. Forskningsdag, Risskov, Denmark.

Severinsen, K., Koldsø, H., Rosenberg, R., Schiøtt, B., Rudnick, G., Wiborg, O. & Sinning, S. (2010). Key residues controlling conformational transitions in the human serotonin transporter. Poster session presented at Gordon Research Conference.

Severinsen, K. (2011). Ligand Binding to the Serotonin Transporter and its functional aspects. Århus Universitet.

Severinsen, K., Kraft, J. F., Koldsø, H., Vinberg, K. A., Rothman, R. B., Partilla, J. S., Wiborg, O., Blough, B., Schiøtt, B. & Sinning, S. (2012). Binding of the Amphetamine-like 1-Phenyl-piperazine to Monoamine Transporters. ACS Chemical Neuroscience, 3(9), 693-705. https://doi.org/10.1021/cn300040f

Severinsen, K., Friis Martens, P. & Sinning, S. (2012). Fat & SERT. Poster session presented at 5th SFB35 symposium on Transmembrane Transporters in Health and Disease, Wien, Austria.

Severinsen, K., Martens, P., Kristensen, K. & Sinning, S. (2013). The Serotonin transporter and its dependence on different lipid raft components. Poster session presented at 6th SFB35 Symposium, Wien, Austria.

Severinsen, K., Koldso, H., Thorup, K. A. V., Schjoth-Eskesen, C., Moller, P. T., Wiborg, O., Jensen, H. H., Sinning, S. & Schiott, B. (2014). Binding of Mazindol and Analogs to the human Serotonin and Dopamine Transporters. Molecular Pharmacology, 85(2), 208-17. https://doi.org/10.1124/mol.113.088922

Severinsen, K., Laursen, L., Kristensen, K. B., Martens, P., Ulvbjerg, M. H. & Sinning, S. (2014). Cholesterol affects the conformational equilibrium and substrate affinity of the serotonin transporter.. Poster session presented at Transmembrane Transporters in Health and Disease, Wien, Austria.

Severinsen, J. E., Bjarkam, C. R., Kiaer-Larsen, S., Olsen, I. M., Nielsen, M. M., Blechingberg, J., Nielsen, A. L., Holm, I. E., Foldager, L., Young, B. D., Muir, W. J., Blackwood, D. H. R., Corydon, T. J., Mors, O. & Børglum, A. D. (2006). Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder. Molecular Psychiatry, 11(12), 1126-38. https://doi.org/10.1038/sj.mp.4001885

Severino, M., Sivasaravanaparan, M., Olesen, L., von Linstow, C. U., Metaxas, A., Bouzinova, E. V., Khan, A. M., Lambertsen, K. L., Babcock, A. A., Gramsbergen, J. B., Wiborg, O. & Finsen, B. (2018). Established amyloid-β pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 4, 215-223. https://doi.org/10.1016/j.trci.2018.04.005

Sestoft, D., Nielsen, JA. & Bertelsen, A. (2005). In memoriam: Mogens Abelin Schou 24.11.1918 - 29.09.2005. Ugeskrift for Læger, 167(46), 4403.

Segurado, R., Detera-Wadleigh, S. D., Levinson, D. F., Ewald, H., Kruse, T. A., Mors, O. & al., E. (2003). Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. American Journal of Human Genetics, 73(1), 49-62.

Schweimer, J. V., Brouard, J. T., Li, Y., Sánchez, C. & Sharp, T. (2022). In vivo electrophysiological study of the targeting of 5-HT₃ receptor-expressing cortical interneurons by the multimodal antidepressant, vortioxetine. European Journal of Neuroscience, 55(6), 1409-1423. https://doi.org/10.1111/ejn.15623

Schumacher, J., Allgulander, C., Binder, E., Deckert, J., Domschke, K., Erhardt, A., Eriksson, E., Ioannidis, J., Kennedy, J., Kristensen, A. S., Maron, E., Metspalu, A., Mors, O., Nurnberger, J., Otowa, T., Philibert, R., Reif, A., Rietschel, M., Sasaki, T. ... McMahon, F. (2009). Genetics of Panic Disorder: A Genome-wide Association Study. Poster session presented at World Congress of PSYCHIATRIC GENETICS: Surfing the Wave of Discovery, San Diego, United States.

Schumacher, J., Kristensen, A. S., Wendland, J. R., Nöthen, M. M., Mors, O. & McMahon, F. J. (2011). The genetics of panic disorder. Journal of Medical Genetics, 48(6), 361-8. https://doi.org/10.1136/jmg.2010.086876

GBD 2021 Demographics Collaborators (2024). Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021. The Lancet, 403(10440), 1989-2056. https://doi.org/10.1016/S0140-6736(24)00476-8

Schou, T. M., Joca, S., Wegener, G. & Bay-Richter, C. (2021). Psychiatric and neuropsychiatric sequelae of COVID-19 - A systematic review. Brain, Behavior, and Immunity, 97, 328-348. https://doi.org/10.1016/j.bbi.2021.07.018

Schosser, A., Butler, A. W., Ising, M., Perroud, N., Uher, R., Ng, M. Y., Cohen-Woods, S., Craddock, N., Owen, M. J., Korszun, A., Jones, L., Jones, I., Gill, M., Rice, J. P., Maier, W., Mors, O., Rietschel, M., Lucae, S., Binder, E. B. ... Lewis, C. M. (2011). Genomewide association scan of suicidal thoughts and behaviour in major depression. P L o S One, 6(7), e20690. https://doi.org/10.1371/journal.pone.0020690

Scholz, C.-J., Jacob, C. P., Buttenschøn, H. N., Kittel-Schneider, S., Boreatti-Hümmer, A., Zimmer, M., Walter, U., Lesch, K.-P., Mors, O., Kneitz, S., Deckert, J. & Reif, A. (2010). Functional variants of TSPAN8 are associated with bipolar disorder and schizophrenia. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 153B(4), 967-972. https://doi.org/10.1002/ajmg.b.31057

Schmidt, L. S., Miller, A. D., Lester, D. B., Bay-Richter, C., Schülein, C., Frikke-Schmidt, H., Wess, J., Blaha, C. D., Woldbye, D. P. D., Fink-Jensen, A. & Wortwein, G. (2010). Increased amphetamine-induced locomotor activity, sensitization, and accumbal dopamine release in M5 muscarinic receptor knockout mice. Psychopharmacology, 207(4), 547-58. https://doi.org/10.1007/s00213-009-1685-2

Schiøtt, B., Celik, L., Sinning, S. & Wiborg, O. (2006). Binding of Serotonin in a Homology Model of the Serotonin Transporter. Poster session presented at 1st European Chemistry Congress, Budapest, Hungary.

Sartori, SB., Hauschild, M., Muigg, P., Slattery, D., Beiderbeck, D., Mathé, A., Wegener, G., Neumann, ID. & Singewald, N. (2010). Modulation of impaired fear extinction by neuropeptides in a psychopathological animal model of trait anxiety: Poster. Abstract from Society for Neuroscience, Washington, United States.

Sartim, A. G., Sales, A. J., Guimarães, F. S. & Joca, S. R. (2018). Hippocampal mammalian target of rapamycin is implicated in stress-coping behavior induced by cannabidiol in the forced swim test. Journal of Psychopharmacology, 32(8), 922-931. https://doi.org/10.1177/0269881118784877

Sartim, A. G., Brito, B. M., Gobira, P. H. & Joca, S. R. L. (2019). Attenuation of glutamatergic and nitrergic system contributes to the antidepressant-like effect induced by capsazepine in the forced swimming test. Behavioural Pharmacology, 30(1), 59-66. Article 30(1). https://doi.org/10.1097/FBP.0000000000000416

Sartim, A. G., Marques, J., Silveira, K. M., Gobira, P. H., Guimarães, F. S., Wegener, G. & Joca, S. R. (2021). Co-administration of cannabidiol and ketamine induces antidepressant-like effects devoid of hyperlocomotor side-effects. Neuropharmacology, 195, Article 108679. https://doi.org/10.1016/j.neuropharm.2021.108679

Sarrafzadeh, S. A., H.Rafati, A., Ardalan, M., Mansouri, D., Tabarsi, P. & Pourpak, Z. (2010). The accuracy of serum galactomannan assay in diagnosing invasive pulmonary aspergillosis. The Iranian Journal of Allergy, Asthma and Immunology.

Sanvicente-Vieira, B., Rothmann, L. M., Esper, N. B., Tondo, L. P., Ferreira, P. E., Buchweitz, A., Franco, A. R. & Grassi-Oliveira, R. (2022). Sex differences in brain regional homogeneity during acute abstinence in cocaine use disorder. Addiction Biology, 27(3), Article e13177. https://doi.org/10.1111/adb.13177

Santos, R. C., Dalfovo, N. P., de Freitas Machado, J., de Azeredo, L. A., Grassi-Oliveira, R., Portuguez, M. W. & Buchweitz, A. (2023). A cross-sectional study of the association between exposure to violence, intelligence, and executive function in Brazilian youths. Psicologia: Reflexao e Critica, 36(1), Article 6. https://doi.org/10.1186/s41155-023-00249-z

Sanchez, C., Bergqvist, P. B., Brennum, L. T., Gupta, S., Hogg, S., Larsen, A. & Wiborg, O. (2003). Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities. Psychopharmacology (Berl), 167(4), 353-362.

Sanchez, C., Nielsen, SM., Pehrson, A., Zhong, H., Lassen, AB., Bisulco, S., Mørk, A., Wegener, G. & Stensbøl, TB. (2011). P. 2. d. 006 The novel antidepressant Lu AA21004 exerts its multi-modal activity through serotonergic targets. European Neuropsychopharmacology, 21, S404-S405.

Sanchez, C., El Khoury, A., Hassan, M., Wegener, G. & Mathe, A. A. (2018). Sex-dependent behavior, neuropeptide profile and antidepressant response in rat model of depression. Behavioural Brain Research, 351, 93-103. https://doi.org/10.1016/j.bbr.2018.05.029

Sanacora, G., Treccani, G. & Popoli, M. (2012). Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders. Neuropharmacology, 62(1), 63-77. https://doi.org/10.1016/j.neuropharm.2011.07.036

Sampaio, A. S. B., Real, C. C., Gutierrez, R. M. S., Singulani, M. P., Alouche, S. R., Britto, L. R. & Pires, R. S. (2021). Neuroplasticity induced by the retention period of a complex motor skill learning in rats. Behavioural Brain Research, 414, Article 113480. https://doi.org/10.1016/j.bbr.2021.113480

Sales, A. J. & Joca, S. R. L. (2018). Antidepressant administration modulates stress-induced DNA methylation and DNA methyltransferase expression in rat prefrontal cortex and hippocampus. Behavioural Brain Research, 343, 8-15. https://doi.org/10.1016/j.bbr.2018.01.022

Sales, A. J., Fogaça, M. V., Sartim, A. G., Pereira, V. S., Wegener, G., Guimarães, F. S. & Joca, S. R. L. (2019). Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. Molecular Neurobiology, 56(2), 1070–1081. https://doi.org/10.1007/s12035-018-1143-4

Sales, A. J., Crestani, C. C., Guimarães, F. S. & Joca, S. R. L. (2018). Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 86, 255-261. https://doi.org/10.1016/j.pnpbp.2018.06.002

Sales, A. J., Maciel, I. S., Suavinha, A. C. D. R. & Joca, S. R. L. (2021). Modulation of DNA Methylation and Gene Expression in Rodent Cortical Neuroplasticity Pathways Exerts Rapid Antidepressant-Like Effects. Molecular Neurobiology, 58(2), 777–794. https://doi.org/10.1007/s12035-020-02145-4

Sales, A. J., Hiroaki-Sato, V. A. & Joca, S. R. L. (2017). Participation of hippocampal nitric oxide synthase and soluble guanylate cyclase in the modulation of behavioral responses elicited by the rat forced swimming test. Behavioural Pharmacology, 28(1), 19-29. https://doi.org/10.1097/FBP.0000000000000263

Sales, A., Biojone, C. & Joca, S. (2016). Site-specific delivery of epigenetic modulating drugs into the rat brain. In Neuromethods (pp. 149-159). Humana Press Inc. https://doi.org/10.1007/978-1-4939-2754-8_10

Sakoh, M., Østergaard, L., Gjedde, A., Røhl, L., Vestergaard-Poulsen, P., Smith, D. F., Le Bihan, D., Sakaki, S. & Gyldensted, C. (2001). Prediction of tissue survival after middle cerebral artery occlusion based on changes in the apparent diffusion of water. Journal of Neurosurgery, 95(3), 450-8.

Sakoh, M., Østergaard, L., Røhl, L., Smith, D. F., Simonsen, C. Z., Sørensen, J. C. H., Vestergaard-Poulsen, P., Gyldensted, C., Sakaki, S. & Gjedde, A. (2000). Relationship between residual cerebral blood flow and oxygen metabolism as predictive of ischemic tissue viability: sequential multitracer positron emission tomography scanning of middle cerebral artery occlusion during the critical first 6 hours after stroke in pigs. Journal of Neurosurgery, 93(4), 647-57.

Said, S., Ladegaard, B. & Sinning, S. (2013). Relaxing a spring-loaded transporter: Increasing the length of intracellular loop 5 domain impacts the overall function of the human serotonin transporter. Poster session presented at 6th SFB35 Symposium, Wien, Austria.

Said, S., Bjerregaard, H., Severinsen, K., Malinauskaite, L., Sahin, C., Nissen, P. & Sinning, S. (2014). The flexibility of the conserved Leu99 is pivotal for overcoming the rate-limiting conformational transition of the human serotonin transporter in serotonin transport. Poster session presented at Transmembrane Transporters in Health and Disease, Wien, Austria.

Said, S., Neubauer, H. A., Müller, H. K. & Sinning, S. (2015). Intracellular loop 5 is important for the transport mechanism and molecular pharmacology of the human serotonin transporter.

Said, S., Neubauer, H. A., Müller, H. K. & Sinning, S. (2015). Intracellular loop 5 is important for the transport mechanism and molecular pharmacology of the human serotonin transporter. Poster session presented at Psykiatriens 10. forskningsdag, Risskov, Denmark.

Said, S., Malinauskaite, L., Grouleff, J., Shahsavar, A., Bjerregaard, H., Noer, P. R., Severinsen, K., Boesen, T., Schiøtt, B., Nissen, P. & Sinning, S. (2016). The molecular mechanism for overcoming the ratelimiting step in monoamine neurotransmitter transport. Poster session presented at Årsmøde for Dansk Selskab for Farmakologi, Toksikologi og Medicinalkemi, Sandbjerg, Denmark.

Said, S. (2020). Novel approaches to conformational and functional studies of the serotonin transporter and the GABA transporter subtype one. Århus Universitet.

Safavimanesh, F., Møller, J., Rasmussen, J. G., H.Rafati, A., Dorph-Petersen, K.-A. & Nyengaard, J. R. (2012). 3D spatial point process modelling for investigating the minicolumn hypothesis in neuroscience. Poster session presented at University of Miami Spatial Statistics Conference, Miami, United States.

Saetre, P., Grove, J., Børglum, A., Mors, O., Werge, T. M., Andreassen, O. A., Vares, M., Agartz, I., Terenius, L. & Jönsson, E. G. (2012). Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age at onset of schizophrenia: no consistent evidence for an association in the Nordic population. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 159B(8).

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Revised 06.02.2023

Karen Jul Madsen