Publications - All publications https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Bcontroller%5D=Publications&cHash=da7a47b09b0e8fbc494e48903cf8d0f2 en-us PURE Extension typo3support@science.au.dk (Web Department) 30 <![CDATA[The Effects of Preoperative Resting Blood Pressure and Nighttime Blood Pressure on the Associations between Perioperative Blood Pressures and Postoperative Complications]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=77803d19-cf51-4b50-89b8-0f3d3eb69f74&tx_pure_pure5%5BshowType%5D=pub&cHash=4742e0f6d4c93d5f9d9a4c4bee8ecf8b Krath, J., Christensen, S. K., Dinesen, C., Gynning, E. B., Juhl-Olsen, P. OBJECTIVES: To describe the associations between perioperative blood pressures and clinical postoperative outcomes, and to investigate if these associations depend on the preoperative resting and nadir nighttime blood pressures.

DESIGN: A prospective, observational study.

SETTING: A single-center study.

PARTICIPANTS: 200 patients undergoing vascular surgery under general anesthesia.

INTERVENTIONS: Preoperative (resting- and nighttime), intraoperative, and postoperative blood pressure measurements were performed.

MEASUREMENTS AND MAIN RESULTS: Intraoperative and postoperative hypotension were defined as time with mean arterial pressure (MAP) < 65 mmHg and the area from the MAP curve up to MAP 65 mmHg (mmHg × min). The burden of postoperative complications was quantified using the Comprehensive Complication Index 30 days after surgery. A hurdle statistical model was used due to the zero-inflated outcome data. In multivariable analyses every minute with MAP < 65 mmHg during anesthesia and in the postanesthesia care unit was associated with a 0.15- and 0.09-point increase in Comprehensive Complication Index at 30 days, respectively. Preoperative resting- and nighttime blood pressures did not significantly modify the associations between intra- or postoperative hypotension and postoperative complications.

CONCLUSIONS: Intraoperative and postoperative hypotension were significantly associated with postoperative complications in vascular surgery patients. There were no statistically significant interactions between these associations and preoperative nighttime blood pressure, or ambulatory resting blood pressure.

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Research Fri, 23 May 2025 02:06:10 +0200 77803d19-cf51-4b50-89b8-0f3d3eb69f74
<![CDATA[Gender-Affirming Hormone Therapy, Quality of Life, and the Role of Oestradiol and Testosterone in Transgender Individuals]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=eb5f7b59-11af-4c3a-8e3b-1d948373ccbb&tx_pure_pure5%5BshowType%5D=pub&cHash=deb9314759e60cd876d06dc81527b2b9 Petersen, E. E.S., Kiy, F., Kesmodel, U. S., et al. Objectives: The present study examines the quality of life (QoL) of transgender and gender-diverse individuals receiving versus not receiving gender-affirming hormone therapy (GAHT) in those assigned male at birth (AMAB) and assigned female at birth (AFAB). It also explores the relationship between QoL and concentrations of oestradiol and testosterone. Methods: This cross-sectional study used the WHOQOL-BREF questionnaire to assess QoL. Participants were categorised into four groups based on assigned sex at birth (AMAB or AFAB) and GAHT status, with non-GAHT participants serving as controls. MANOVA and t-tests were used to compare QoL between groups, and linear regression analyses examined associations between QoL and oestradiol/testosterone concentrations in AMAB and AFAB participants. Results: The study included 360 participants: 169 AMAB (143 GAHT, 26 controls) and 191 AFAB (141 GAHT, 50 controls). GAHT recipients had significantly higher QoL than controls in both AMAB (p < 0.01) and AFAB (p = 0.02) groups, particularly in the psychological health domain (D2). AFAB participants reported higher overall QoL than AMAB in both GAHT (p = 0.01) and control (p = 0.04) groups, with significance in the social domain among GAHT participants. No significant relationship was found between oestradiol concentrations and QoL for participants AMAB. However, a significant relationship between testosterone concentrations and QoL was observed only in the social relationship domain (D3) for participant AFAB. Conclusion: This study highlights the benefits of GAHT for QoL and differences in QoL between AMAB and AFAB individuals.

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Research Wed, 01 Jan 2025 02:06:10 +0100 eb5f7b59-11af-4c3a-8e3b-1d948373ccbb
<![CDATA[The Selective Serotonin 5-HT<sub>2A</sub> Receptor Agonist (S)-3-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)piperidine (LPH-5) Induces Persistent and Robust Antidepressant-Like Effects in Rodents]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=e8093cbf-1dd1-45d3-b787-aee03b8eea56&tx_pure_pure5%5BshowType%5D=pub&cHash=069a363286e5fead39ce3f179538ff37 Jensen, A. A., Cecchi, C. R., Hibicke, M., et al. Psychedelics have emerged as a promising treatment for mental health disease, and the therapeutic potential of psilocybin and lysergic acid diethylamide (LSD) is presently being pursued in numerous clinical trials. This has prompted a search for novel agents with more specific pharmacological activities than the rather promiscuous classical psychedelics. Here we present the detailed pharmacological characterization of one such compound, LPH-5 [(S)-3-(2,5-dimethoxy-4-(trifluoromethyl)phenyl)piperidine]. LPH-5 was found to be a potent partial agonist at the 5-HT2A receptor (5-HT2AR) with pronounced selectivity for 5-HT2AR over the related 5-HT2BR and 5-HT2CR in a range of functional assays. LPH-5 dose-dependently induced head-twitch responses (HTR) as well as robust acute and persistent antidepressant-like effects in rats. These results suggest that selective 5-HT2AR activation holds antidepressant potential and indicate that this activity component is key for the therapeutics effects of classical psychedelics.

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Research Wed, 01 Jan 2025 02:06:10 +0100 e8093cbf-1dd1-45d3-b787-aee03b8eea56
<![CDATA[Application of microRNA In Situ Hybridization on Long-term Stored Human Formalin-fixed Paraffin-embedded Brain Samples from Psychiatric Patients]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=16c6663e-ce07-4cc6-97e2-cb3d08ca0ed4&tx_pure_pure5%5BshowType%5D=pub&cHash=4caa333c89d7c4d0689f5e6b22dfef18 Søkilde, R., Kaadt, E., Kristensen, L. S., et al. Here, we report that long-term stored human brain samples, formalin-fixed paraffin-embedded (FFPE) from The Brain Collection, University of Southern Denmark, Denmark (https://www.sdu.dk/en/forskning/bridge/the-brain-collection), can be used for in situ hybridization (ISH) analysis of selected microRNAs (miRNAs). The Human Brain Collection consists of brains from 9479 subjects who died at a Danish State Mental Hospital in the period of 1945–1982. In the present study we included tissue specimens from prefrontal cortex (PFC) and hippocampus (HIP) from 163 patients diagnosed with schizophrenia, bipolar disorder, or major depressive disorder. Initially, the Nanostring nCounter platform was used to identify miRNA candidates for ISH analysis using the miRNAscope technology. Based on the Nanostring nCounter quantifications with bulk tissue, we identified and selected 10 miRNAs from PFC (miR-9-5p, miR-29b-3p, miR-30c-5p, miR-124-3p, miR-125b-5p, miR-138-5p, miR-181a-5p, miR-224-5p, miR-302d-3p, and miR-432-5p) and 6 miRNAs from HIP (let-7a-5p, miR-7-5p, miR-124-3p, miR-127-3p, miR-145-5p and miR-149-5p). miRNAscope ISH analysis was then performed with the respective probes on 30 PFC and 30 HIP samples, respectively. In the PFC six miRNAs (miR-9-5p, miR-29b-3p, miR-124-3p, miR-125b-5p, miR-138-5p, and miR-181a-5p) were detected and four (miR-145-5p, let-7a-5p, miR-124-3p and miR-7-5p) in the HIP samples. In both brain regions miR-124-3p was the most abundantly expressed. We conclude, that the combination of the Nanostring nCounter technology and the miRNAscope analysis is a valid approach to study spatial expression of specific miRNAs in these up to 76 years old FFPE blocks. This opens a new avenue of possibilities for studying the underlying epigenetic mechanisms in mental disorders.

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Research Wed, 01 Jan 2025 02:06:10 +0100 16c6663e-ce07-4cc6-97e2-cb3d08ca0ed4
<![CDATA[Premeal Whey Protein Lowers Postprandial Blood Glucose in Women With Gestational Diabetes Mellitus]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=1f1af934-4517-41b9-9d48-669986aa9880&tx_pure_pure5%5BshowType%5D=pub&cHash=d3b8dfaf7fd872d7c286b9d5081a04d5 Smedegaard, S., Kampmann, U., Ovesen, P. G., et al. OBJECTIVE To examine how whey protein served as a premeal affects postprandial glucose excursions in women with gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS A placebo-controlled, single-blinded, crossover, randomized trial including women with and without GDM (20–36 weeks’ gestation) was performed. Participants were studied in the laboratory and at home. In the laboratory, women were randomized to consume 20 g of whey or placebo 30 min before undergoing, 7–14 days later, a 75-g oral glucose tolerance test (OGTT). Blood was sampled consecutively 3 hours following the OGTT. The primary end point was the incremental area under the curve (iAUC) for glucose. At home, participants wore continuous glucose monitors and, on subsequent days, randomly consumed 0, 10, 15, 20, and 30 g of whey 30 min before breakfast. RESULTS Twelve women with GDM and 12 pregnant women with normal glucose tolerance (NGT) to part in the trials. Intake of premeal whey resulted in lowered peak glucose by 21.0 mmol/L (95% CI 21.6 to 20.4) in women with GDM and 20.7 mmol/L (95% CI 21.3 to 20.1) in women without GDM compared with placebo. Insulin, glucose-dependent insulinotropic polypeptide, and glucagon-like peptide-1 levels increased rapidly after whey consumption in both groups. At home, a premeal of 30 g of whey dose-dependently reduced incremental glucose peaks with a maximum of 22.0 mmol/L (95% CI 22.5 to 21.5) in women with GDM compared with placebo. CONCLUSIONS Premeal whey consumption acutely lowers postprandial blood glucose in women with GDM and those with NGT, with 15–30 g lowering the glucose iAUC of women with GDM. These findings emphasize the need for long-term studies to assess the impact of whey premeals in pregnancies affected by GDM.

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Research Sun, 01 Jun 2025 02:06:10 +0200 1f1af934-4517-41b9-9d48-669986aa9880
<![CDATA[Preclinical Studies of Serotonin and Nitric Oxide in Affective Disorders]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=31db164a-2147-43f2-a665-0560f0a7faab&tx_pure_pure5%5BshowType%5D=pub&cHash=255119d890ca5863e397d77aa8c91555 Wegener, G. Research Sat, 01 Jan 2011 02:06:10 +0100 31db164a-2147-43f2-a665-0560f0a7faab <![CDATA[Towards a Neurobiology of Major Depression. Structural and Functional Cerebral Abnormalities]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=b8314df0-aa9c-11da-bee9-02004c4f4f50&tx_pure_pure5%5BshowType%5D=pub&cHash=6691a8c0f11f14a7dd266672e5e910b3 Videbech, P. Research Sat, 01 Jan 2005 02:06:10 +0100 b8314df0-aa9c-11da-bee9-02004c4f4f50 <![CDATA[Novel drug targets of depression - Focusing on non-coding RNAs]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=f5e6e15e-513e-48b5-91d2-ac94904426f3&tx_pure_pure5%5BshowType%5D=pub&cHash=d146246dcdde65244b6b5e4de717a23e Kaadt, E. Research Mon, 01 Jan 2024 02:06:10 +0100 f5e6e15e-513e-48b5-91d2-ac94904426f3 <![CDATA[Metabolism and therapeutic drug monitoring of quetiapine]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=3771f030-cbd8-11db-bee9-02004c4f4f50&tx_pure_pure5%5BshowType%5D=pub&cHash=6b8b88d7d861f408d1d34497a25d53a8 Hasselstrøm, J. Research Mon, 01 Jan 2007 02:06:10 +0100 3771f030-cbd8-11db-bee9-02004c4f4f50 <![CDATA[Characterisation of the ligand binding site of the human serotonin transporter]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=e9d1b7f0-aa97-11da-bee9-02004c4f4f50&tx_pure_pure5%5BshowType%5D=pub&cHash=110fa05572333a87273c464cc6b4360e Sinning, S. Research Sat, 01 Jan 2005 02:06:10 +0100 e9d1b7f0-aa97-11da-bee9-02004c4f4f50 <![CDATA[Synaptic Vesicle Glycoprotein 2A imaging of non-pharmacological therapies for Pakinson's disease]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=d07888dc-637c-4168-8af8-859104a4ae13&tx_pure_pure5%5BshowType%5D=pub&cHash=ca00078288e7a5ca2d98ebcdda45e40a Henrique Binda, K. Research Mon, 01 Jan 2024 02:06:10 +0100 d07888dc-637c-4168-8af8-859104a4ae13 <![CDATA[Involvement of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the antidepressant-like effect and in the stress response]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=49cc2008-814d-407b-abaf-931028971226&tx_pure_pure5%5BshowType%5D=pub&cHash=1263e650938f94ccc7ac1c6a034066f3 Moura Silveira, K. Research Sun, 01 Oct 2023 02:06:10 +0200 49cc2008-814d-407b-abaf-931028971226 <![CDATA[Experimental investigations of depression and stroke as comorbidities]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=6bddd220-e32f-427f-81e1-87b438c681c7&tx_pure_pure5%5BshowType%5D=pub&cHash=28700af44780ddf6eac77993d0461f97 Happ, D. F. Research Wed, 01 Jan 2020 02:06:10 +0100 6bddd220-e32f-427f-81e1-87b438c681c7 <![CDATA[Understanding In Vivo Modelling of Depression]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=48009d71-66ce-4f61-93a9-fb8b63c708ea&tx_pure_pure5%5BshowType%5D=pub&cHash=c688f9e82acc1ee441a388bcb6b0ee1a Bannach-Brown, A. Research Mon, 01 Jan 2018 02:06:10 +0100 48009d71-66ce-4f61-93a9-fb8b63c708ea <![CDATA[Impact of gut microbiota modulation on host behavior and metabolism]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=9e9a2fd5-a9d2-44f8-988c-1f8bc973b44f&tx_pure_pure5%5BshowType%5D=pub&cHash=4de745538cf14558cb4aad6a1c0d69e6 Tillmann, S. Research Mon, 01 Jan 2018 02:06:10 +0100 9e9a2fd5-a9d2-44f8-988c-1f8bc973b44f <![CDATA[Early Life Programming of Brain and Behaviour]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=7210602d-dded-48fa-9b4b-388f72961616&tx_pure_pure5%5BshowType%5D=pub&cHash=ae9df9032c1203ac88e26c554a88a8d5 Winther, G. Research Mon, 01 Jan 2018 02:06:10 +0100 7210602d-dded-48fa-9b4b-388f72961616 <![CDATA[Characterization of tryptophan metabolites in depression and recovery]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=61ad095f-a64d-4b78-8b13-185942dbfb5c&tx_pure_pure5%5BshowType%5D=pub&cHash=e0486663591bb7b1c860d8784d9d9f3b Eskelund, A. Research Tue, 05 Sep 2017 02:06:10 +0200 61ad095f-a64d-4b78-8b13-185942dbfb5c <![CDATA[The neural basis of cognitive deficits studied in the chronic mild stress rat model of depression]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=e7ad3948-e3c1-47d0-a730-7a4c15999bf6&tx_pure_pure5%5BshowType%5D=pub&cHash=d57736682091dff6bce363181e11a08a Henningsen, K. Research Sun, 01 Jan 2012 02:06:10 +0100 e7ad3948-e3c1-47d0-a730-7a4c15999bf6 <![CDATA[Discovery of novel interacting proteins of the sortilin receptor - mechanistic insights into the regulation of a key protein involved in neurological and psychiatric disorders]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=ece1b80f-fa56-46e5-8df5-34c9a3029f81&tx_pure_pure5%5BshowType%5D=pub&cHash=d4de89d120f57f04ae2e44bc65af132e Overby, M. Research Sat, 01 Oct 2022 02:06:10 +0200 ece1b80f-fa56-46e5-8df5-34c9a3029f81 <![CDATA[Novel approaches to modeling pre-stroke depression in the rat]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=60577eae-a789-42e2-b98c-3fa6b3bcce8d&tx_pure_pure5%5BshowType%5D=pub&cHash=b0e5922a1b0399dfe875d6f39b7d88d2 Bay, V. Research Mon, 01 Jan 2018 02:06:10 +0100 60577eae-a789-42e2-b98c-3fa6b3bcce8d <![CDATA[Preclinical Studies on Metabolic Stress and Probiotic Treatment in Major Depressive Disorder]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=c1946310-a35b-44b1-aeb7-e31a1770f0be&tx_pure_pure5%5BshowType%5D=pub&cHash=490a743682bc292a01a5de2e0478974c Abildgaard, A. Research Fri, 01 Jan 2016 02:06:10 +0100 c1946310-a35b-44b1-aeb7-e31a1770f0be <![CDATA[Chronobiology in the Chronic Mild Stress Animal Model of Depression]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=3cdf8d3c-0f0a-4b4a-8a72-3f69d9d81713&tx_pure_pure5%5BshowType%5D=pub&cHash=ecc22dbe11ed6b3566cf65187196241d Christiansen, S. L. Research Fri, 01 Jan 2016 02:06:10 +0100 3cdf8d3c-0f0a-4b4a-8a72-3f69d9d81713 <![CDATA[A statistical perspective on association studies of psychiatric disorders]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=c3aa4def-a8dd-4983-a324-191879e3bb10&tx_pure_pure5%5BshowType%5D=pub&cHash=41a1ce6560f2dec4b044de9551aa7a7c Foldager, L. Gene-gene (GxG) and gene-environment (GxE) interactions likely play an important role in the aetiology of complex diseases like psychiatric disorders. Thus, we aim at investigating methodological aspects of and apply methods from statistical genetics taking interactions into account. In addition we consider issues concerning detection limits of continuous traits, single-marker tests, analysis of sex chromosomes, and accumulation of signals. Disorders investigated include schizophrenia, bipolar disorder, panic disorder, and suicidal behaviour. In addition to this, we use computer simulations.

Papers 1 and 2 were motivated by the hypothesis that defects of the immune system may increase risk of psychiatric disorders. We consider two components from the lectin pathway of activation: mannan-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) via continuous traits (protein level), dichotomous trait (disease status) as well as genetic markers including GxG interactions. We use Tobit regression to handle data below the detection limit of MBL.

The involvement of the immune system may also be less direct as seen by the findings how infections impact disorders, e.g. via interaction between genes and maternal infection by virus. Paper 3 presents the initial steps (mainly data construction) of an ongoing simulation study aiming at guiding decisions by comparing methods for GxE interaction analysis including both traditional two-step logistic regression, exhaustive searches using efficient algorithms, and data mining or machine learning methods like model-based multifactor dimensionality reduction (MB-MDR) and logic regression with feature selection (logicFS).

The analysis of sex chromosomes may require different approaches than those commonly used for autosomes. In paper 4 we include a marker from the X chromosome and discuss how to analyse with and without the assumption of inactivation of one of the female X chromosomes early in development. In addition this paper includes analysis of the interaction between genetic markers and age and sex.

Haplotype analysis and other multilocus approaches may increase the power to detect disease association but introduce also the problem of determining the gametic phase. In papers 1 and 2 we analyse multilocus genotypes and haplotypes but assuming known phase as linkage disequilibrium (LD) implies only few haplotypes to be commonly observed using these markers. However, the validity of the identified haplotypes is also checked by inferring phased haplotypes from genotypes. Haplotype analysis is also used in paper 5 which is otherwise an example of a focused approach to narrow down a previously found signal to search for more precise positions of disease causing mutations and functional implications.

In stark contrast to such a focused approach stand genome-wide studies (GWAS). Here it is truly important to address the enormous increase in type I error introduced when performing hundreds of thousands or even millions of statistical tests. The commonly accepted genome-wide threshold for single-marker association tests has become 5e-8 but searching for interactions genome-wide results in drastically many more tests and thus the need of an even lower p-value threshold. Lowering the threshold comes at the unfortunate but inevitable expense of increasing the probability of type II errors and thus lowering the power to detect association. Statistical procedures where the test statistics initially are grouped according to some criteria, e.g. by candidate regions or functional pathways, may be one way to decrease the number of tests instead of lowering the threshold for significance. Yet, in paper 6 we propose the Landscape method to summarise a series of sequentially ordered test values without the need of more or less arbitrary prior grouping.

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Research Wed, 11 Jun 2014 02:06:10 +0200 c3aa4def-a8dd-4983-a324-191879e3bb10
<![CDATA[Identification and Characterisation of Serotonin Transporter Interacting Proteins]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=612a5380-f832-11dd-8f9a-000ea68e967b&tx_pure_pure5%5BshowType%5D=pub&cHash=04c3d7c94861df1c444ffdabe79aaa08 Müller, H. K. Research Sun, 01 Jan 2006 02:06:10 +0100 612a5380-f832-11dd-8f9a-000ea68e967b <![CDATA[Mapping and characterization of an allosteric mechanism on the serotonin transporter]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=3cf088e0-850c-11db-bee9-02004c4f4f50&tx_pure_pure5%5BshowType%5D=pub&cHash=139e8c162b268ae33c8e20a63f2980a1 Neubauer, H. A. Research Sun, 01 Jan 2006 02:06:10 +0100 3cf088e0-850c-11db-bee9-02004c4f4f50 <![CDATA[Cognitive Function in Major Depression and Normal Subjects]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=dd8fc540-6b43-11dc-bee9-02004c4f4f50&tx_pure_pure5%5BshowType%5D=pub&cHash=cb81f8c1ec2b96b284d16675e9a7247a Jensen, B. R. Research Tue, 01 Jan 2002 02:06:10 +0100 dd8fc540-6b43-11dc-bee9-02004c4f4f50 <![CDATA[Behavioural and molecular effects induced by Cannabidiol in animal models of depression]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=21ad1f99-520c-4214-b0af-7d625e537d75&tx_pure_pure5%5BshowType%5D=pub&cHash=979edfc973867d1203cc50c151a8120a Silote, G. Research Fri, 01 Jan 2021 02:06:10 +0100 21ad1f99-520c-4214-b0af-7d625e537d75 <![CDATA[Translational Imaging of Synaptic Dysfunction in Mental Health Disorders]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=a3dc46d1-d091-4b4c-bbf6-4e0b57f13486&tx_pure_pure5%5BshowType%5D=pub&cHash=28d3a1a9e16c7f647fb74a0051cbe1c6 Bærentzen, S. L. Research Mon, 01 Jan 2024 02:06:10 +0100 a3dc46d1-d091-4b4c-bbf6-4e0b57f13486 <![CDATA[Preclinical Studies of the Opiod System in Depression]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=8921a640-6879-4485-aaa0-c691c86215ff&tx_pure_pure5%5BshowType%5D=pub&cHash=f6a97a4f10f0cb5c1257edc3ae2da257 Varastehmoradi, B. Research Sat, 01 Jul 2023 02:06:10 +0200 8921a640-6879-4485-aaa0-c691c86215ff <![CDATA[Novel approaches to conformational and functional studies of the serotonin transporter and the GABA transporter subtype one]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=652e2ac8-b45e-4a37-b47c-a4eceb841511&tx_pure_pure5%5BshowType%5D=pub&cHash=c637b6c5111a09040f01d41238774b4a Said, S. Research Wed, 01 Jan 2020 02:06:10 +0100 652e2ac8-b45e-4a37-b47c-a4eceb841511 <![CDATA[The Influence of Rapid-acting Antidepressants on the Neuronal and Non-neuronal Plasticity of the Hippocampus in a Genetic Rat Model of Depression]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=14c19ac4-26a4-4694-9756-650c885491a7&tx_pure_pure5%5BshowType%5D=pub&cHash=e5985b03702ccddbfb8dd323858442ed Ardalan, M. Research Fri, 01 Jan 2016 02:06:10 +0100 14c19ac4-26a4-4694-9756-650c885491a7 <![CDATA[Sodium dependent acid/base transport in regulation of intracellular pH in rat choroid plexus]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=208158b0-42a0-40a7-869e-05f641941ce8&tx_pure_pure5%5BshowType%5D=pub&cHash=b01aa2d4745a4336d42f8d57a3673bca Bouzinova, E. Research Fri, 01 Jun 2007 02:06:10 +0200 208158b0-42a0-40a7-869e-05f641941ce8 <![CDATA[Comparative proteomics in a chronic mild stress rat model of depression - fingerprints of stress reactivity and treatment response]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=c7c7bb82-4889-4bd5-a1c0-d627b189cf94&tx_pure_pure5%5BshowType%5D=pub&cHash=9f6895e0fa1d93c47d8e2e9c693a3d50 Bisgaard, C. Research Sun, 01 Jan 2012 02:06:10 +0100 c7c7bb82-4889-4bd5-a1c0-d627b189cf94 <![CDATA[Gene Expression profiling study in a rat chronic mild stress model of depression]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=576eb3b0-d781-11df-a891-000ea68e967b&tx_pure_pure5%5BshowType%5D=pub&cHash=f863506035043f254a26e77161b5c956 Christensen, T. Research Fri, 01 Jan 2010 02:06:10 +0100 576eb3b0-d781-11df-a891-000ea68e967b <![CDATA[MRI-defined cerebral white matter lesions in late-onset major depression]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=46db1150-22d3-11df-b95d-000ea68e967b&tx_pure_pure5%5BshowType%5D=pub&cHash=4061fff507b2803130e7318a4c29fd08 Dalby, R. B. Research Thu, 01 Jan 2009 02:06:10 +0100 46db1150-22d3-11df-b95d-000ea68e967b <![CDATA[Carbogen Inhalation Increases Oxygen Transport to Brain Tissue]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=cb534310-9122-11dd-868b-000ea68e967b&tx_pure_pure5%5BshowType%5D=pub&cHash=18dfda2b4d58f8b74736dd48b4e76cbe Ashkanian, M. Research Tue, 01 Jan 2008 02:06:10 +0100 cb534310-9122-11dd-868b-000ea68e967b <![CDATA[Neuronal changes in the dorsal raphe nucleus in depression?]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=491537b0-8bbd-11dd-bd84-000ea68e967b&tx_pure_pure5%5BshowType%5D=pub&cHash=0de98c6088d34052673ef14e7775bb8e Dorph-Petersen, K. Research Mon, 01 Jan 2001 02:06:10 +0100 491537b0-8bbd-11dd-bd84-000ea68e967b <![CDATA[Identification of susceptibility genes for psychiatric diseases based on structural chromosome aberrations]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=42f5b900-fadc-11da-bee9-02004c4f4f50&tx_pure_pure5%5BshowType%5D=pub&cHash=cea696aef3254a51c34161ea086598d3 Jacobsen, I. S. Research Sun, 01 Jan 2006 02:06:10 +0100 42f5b900-fadc-11da-bee9-02004c4f4f50 <![CDATA[Behavioral, morphological and molecular characterization of Neuroglobin knock-out mice]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=c5da635c-e0c2-4394-8901-6577526a9374&tx_pure_pure5%5BshowType%5D=pub&cHash=f9368aee24c4da711173f43fe4583f37 Danladi, J. Research Thu, 01 Sep 2022 02:06:10 +0200 c5da635c-e0c2-4394-8901-6577526a9374 <![CDATA[Translational assessment of cognitive impairments in depression models]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=1a4a466d-5cb7-4ed4-a256-69dc74386f6f&tx_pure_pure5%5BshowType%5D=pub&cHash=4842ed1387c9b0b51d5b999838bc3ecb Martis, L. Research Mon, 01 Jan 2018 02:06:10 +0100 1a4a466d-5cb7-4ed4-a256-69dc74386f6f <![CDATA[Identification and analyses of genetic risk factors for panic disorder]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=c207c744-2a45-4395-8b6d-89bd44ee2938&tx_pure_pure5%5BshowType%5D=pub&cHash=53b2c709916106235319e593167c880f Gregersen, N. Research Thu, 01 Jan 2015 02:06:10 +0100 c207c744-2a45-4395-8b6d-89bd44ee2938 <![CDATA[Challenging the immune system in rodents and its association to depression]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=b612e8ba-8ebc-4fb1-8a27-35e72968175e&tx_pure_pure5%5BshowType%5D=pub&cHash=298e4522df924def907b7ad85ea70897 Fischer, C. Research Thu, 01 Jan 2015 02:06:10 +0100 b612e8ba-8ebc-4fb1-8a27-35e72968175e <![CDATA[Aspects of Cardiovascular Disease in Depression]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=6abb72f8-a9cf-46d5-a3aa-390887d918a8&tx_pure_pure5%5BshowType%5D=pub&cHash=e31eb5f4c27996e09300b9555f4a3134 Devantier, T. A. Research Tue, 01 Jan 2013 02:06:10 +0100 6abb72f8-a9cf-46d5-a3aa-390887d918a8 <![CDATA[Comorbidity between cannabis use and psychiatric disorders]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=7f310fd0-acb6-11dd-889c-000ea68e967b&tx_pure_pure5%5BshowType%5D=pub&cHash=accebf439268cfd0b292ead70bcd834c Arendt, M. Research Tue, 01 Jan 2008 02:06:10 +0100 7f310fd0-acb6-11dd-889c-000ea68e967b <![CDATA[Molecular Mechanisms in Treatment and Pathology of Depression]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=f0908020-9078-11dd-bd84-000ea68e967b&tx_pure_pure5%5BshowType%5D=pub&cHash=068aa294bac79b9f51b04b4cb7dfd6ae Bonefeld, B. Research Mon, 01 Jan 2007 02:06:10 +0100 f0908020-9078-11dd-bd84-000ea68e967b <![CDATA[Regulation and trafficking of the monoamine transporters]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=fd7dc470-258c-11dd-be51-000ea68e967b&tx_pure_pure5%5BshowType%5D=pub&cHash=87adfbedeac380914e87401cc57ce600 Fjorback, A. W. Research Tue, 01 Jan 2008 02:06:10 +0100 fd7dc470-258c-11dd-be51-000ea68e967b <![CDATA[Attitudes towards psychiatric genetics among future users and providers of psychiatric genetic testing and counselling]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=370113a0-0c74-11dd-b919-000ea68e967b&tx_pure_pure5%5BshowType%5D=pub&cHash=56accdc7d95eb1970ab74b3275faf64b Madsen, M. M. L. Research Tue, 01 Jan 2008 02:06:10 +0100 370113a0-0c74-11dd-b919-000ea68e967b <![CDATA[Pathophysiology of depression and mechanisms of antidepressant treatments; focus on neurogenesis and gene expression in a chronic mild stress animal model of depression]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=fedda5e0-680b-11dc-bee9-02004c4f4f50&tx_pure_pure5%5BshowType%5D=pub&cHash=309ccb2520cc9975a9cb1135ea6d20cf Jayatissa, M. N. Research Mon, 01 Jan 2007 02:06:10 +0100 fedda5e0-680b-11dc-bee9-02004c4f4f50 <![CDATA[The Interplay between the Estrogen Ensemble and Antidepressants]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=4f0f7726-4104-473a-ba41-44ebaf0a470d&tx_pure_pure5%5BshowType%5D=pub&cHash=56cfb90abb0e22b4a1e25777fc621f53 Arjmand, S. Research Mon, 01 Jan 2024 02:06:10 +0100 4f0f7726-4104-473a-ba41-44ebaf0a470d <![CDATA[Novelty-induced Consolidation of Hippocampus-Dependent Memories]]> https://tnu.au.dk/publications/all-publications?tx_pure_pure5%5Baction%5D=single&tx_pure_pure5%5Bcontroller%5D=Publications&tx_pure_pure5%5Bid%5D=00c85d04-effb-4fa1-8edf-a8f4e181178e&tx_pure_pure5%5BshowType%5D=pub&cHash=73372d8242397f0f8265ab8c74af93b5 Højgaard, K. Research Mon, 01 Jan 2024 02:06:10 +0100 00c85d04-effb-4fa1-8edf-a8f4e181178e