Our research investigates two main areas in neuropsychiatry linked to possible intervention strategies.: the effects of diet on brain function through the brain-gut axis, and biological mechanisms underlying affective disorders, in particular PTSD and depression.

1. We focus on the brain-gut axis, examining how diet influences inflammation, metabolic function, and mood regulation. This includes detailed studies of dietary impacts on inflammatory mechanisms and the pathways that control the duration and intensity of these responses. By utilizing animal models, we aim to reveal how metabolic shifts and inflammation from dietary factors may contribute to – or alleviate - mood.
2. Secondly, we focus on the neural circuitry and mechanisms involved in PTSD and depression, particularly concerning memory processes and use of rapid-acting antidepressant strategies. Using advanced preclinical models and tools such as DREADD, optogenetics, and genetic sensors, we study specific brain regions involved in mood regulation and memory functions. Our research aims to map and manipulate the circuits associated with these disorders, with the goal of understanding the impact of the disease and pharmacological intervention on memory processes and affective states.

A key focus is investigating rapid-acting antidepressant interventions, including ketamine, psychedelics, and electroconvulsive therapy. These interventions are analyzed for their potential to rapidly alleviate symptoms by modulating critical circuits in animal models. Advanced phenotyping techniques allow us to capture precise behavioral, neural, and metabolic changes in response to both the underlying disorders and the therapeutic interventions.

Our research focuses on two key neuropsychiatric areas with potential for targeted interventions: diet’s impact on brain function via the brain-gut axis and biological mechanisms underlying affective disorders, particularly PTSD and depression. We examine how diet influences inflammation, metabolism, and mood regulation, using animal models to assess how dietary factors can shift mood-related metabolic and inflammatory pathways. Additionally, we study neural circuits associated with memory and mood in PTSD and depression, employing advanced techniques like DREADD and optogenetics. A major aim is to evaluate rapid-acting antidepressants, including ketamine and psychedelics, for their potential to quickly modulate affective states and memory.