Publications 2019

2019

Ribeiro, D. E., Casarotto, P. C., Spiacci, A. J., Fernandes, G. G., Pinheiro, L. C., Tanus-Santos, J. E., Zangrossi, H. J., Guimarães, F. S., Joca, S. R. L. & Biojone, C. (2019). Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 93(July), 232-239. https://doi.org/10.1016/j.pnpbp.2019.04.007

Musazzi, L., Sala, N., Tornese, P., Gallivanone, F., Belloli, S., Conte, A., Di Grigoli, G., Chen, F., Ikinci, A., Treccani, G., Bazzini, C., Castiglioni, I., Nyengaard, J. R., Wegener, G., Moresco, R. M. & Popoli, M. (2019). Acute Inescapable Stress Rapidly Increases Synaptic Energy Metabolism in Prefrontal Cortex and Alters Working Memory Performance. Cerebral Cortex, 29(12), 4948–4957. https://doi.org/10.1093/cercor/bhz034

Bannach-Brown, A., Tillmann, S., MacLeod, M. R. & Wegener, G. (2019). Administration of galacto-oligosaccharide prebiotics in the Flinders Sensitive Line animal model of depression. BMJ Open Science, 3(1), e000017. Article e000017. https://doi.org/10.1136/bmjos-2018-000017

Metaxas, A., Thygesen, C., Kempf, S. J., Anzalone, M., Vaitheeswaran, R., Petersen, S., Landau, A. M., Audrain, H., Teeling, J. L., Darvesh, S., Brooks, D. J., Larsen, M. R. & Finsen, B. (2019). Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease. Scientific Reports, 9(1), Article 15758. https://doi.org/10.1038/s41598-019-52357-5

Tillmann, S., Abildgaard, A., Winther, G. & Wegener, G. (2019). Altered fecal microbiota composition in the Flinders Sensitive Line rat model of depression. Psychopharmacology, 236(5), 1445-1457. https://doi.org/10.1007/s00213-018-5094-2

Ribeiro, D. E., Müller, H. K., Elfving, B., Eskelund, A., Joca, S. & Wegener, G. (2019). Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation. Journal of Psychopharmacology, 33(11), 1436-1446. https://doi.org/10.1177/0269881119872173

Barbu, M. C., Zeng, Y., Shen, X., Cox, S. R., Clarke, T.-K., Gibson, J., Adams, M. J., Johnstone, M., Haley, C. S., Lawrie, S. M., Deary, I. J., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 23andMe Research Team, McIntosh, A. M. & Whalley, H. C. (2019). Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4(1), 91-100. https://doi.org/10.1016/j.bpsc.2018.07.006

Sartim, A. G., Brito, B. M., Gobira, P. H. & Joca, S. R. L. (2019). Attenuation of glutamatergic and nitrergic system contributes to the antidepressant-like effect induced by capsazepine in the forced swimming test. Behavioural Pharmacology, 30(1), 59-66. Article 30(1). https://doi.org/10.1097/FBP.0000000000000416

Martis, L. S., Wiborg, O., Holmes, M. C. & Harris, A. P. (2019). BDNF ^+/− rats exhibit depressive phenotype and altered expression of genes relevant in mood disorders. Genes, Brain and Behavior, 18(2), Article e12546. https://doi.org/10.1111/gbb.12546

Tillmann, S., Happ, D. F., Mikkelsen, P. F., Geisel, J., Wegener, G. & Obeid, R. (2019). Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression. Behavioural Brain Research, 364, 274-280. https://doi.org/10.1016/j.bbr.2019.02.011

Kaadt, E., Mumm, B. H., Andersen, S. N., Damgaard, C. K. & Elfving, B. (2019). Biomarkers of depression - Focusing on non-coding RNA. 1:1-32.

Paternoster, V., Svanborg, M., Edhager, A. V., Rajkumar, A. P., Eickhardt, E. A., Pallesen, J., Grove, J., Qvist, P., Fryland, T., Wegener, G., Nyengaard, J. R., Mors, O., Palmfeldt, J., Børglum, A. D. & Christensen, J. H. (2019). Brain proteome changes in female Brd1+/- mice unmask dendritic spine pathology and show enrichment for schizophrenia risk. Neurobiology of Disease, 124, 479-488. https://doi.org/10.1016/j.nbd.2018.12.011

Sales, A. J., Fogaça, M. V., Sartim, A. G., Pereira, V. S., Wegener, G., Guimarães, F. S. & Joca, S. R. L. (2019). Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. Molecular Neurobiology, 56(2), 1070–1081. https://doi.org/10.1007/s12035-018-1143-4

Anzabi, M., Angleys, H., Aamand, R., Ardalan, M., Mouridsen, K., Rasmussen, P. M., Sørensen, J. C. H., Plesnila, N., Østergaard, L. & Iversen, N. K. (2019). Capillary flow disturbances after experimental subarachnoid hemorrhage: a contributor to delayed cerebral ischemia? Microcirculation, 26(3), Article e12516. https://doi.org/10.1111/micc.12516

Tornese, P., Sala, N., Bonini, D., Bonifacino, T., La Via, L., Milanese, M., Treccani, G., Seguini, M., Ieraci, A., Mingardi, J., Nyengaard, J. R., Calza, S., Bonanno, G., Wegener, G., Barbon, A., Popoli, M. & Musazzi, L. (2019). Chronic mild stress induces anhedonic behavior and changes in glutamate release, BDNF trafficking and dendrite morphology only in stress vulnerable rats. The rapid restorative action of ketamine. Neurobiology of Stress, 10, Article 100160. https://doi.org/10.1016/j.ynstr.2019.100160

Hvilsom, A. S. T., Lillethorup, T. P., Iversen, P., Doudet, D. J., Wegener, G. & Landau, A. M. (2019). Cortical and striatal serotonin transporter binding in a genetic rat model of depression and in response to electroconvulsive stimuli. European Neuropsychopharmacology, 29(4), 493-500. https://doi.org/10.1016/j.euroneuro.2019.02.009

Herzog, D., Wegener, G., Lieb, K., Müller, M. & Treccani, G. (2019). Decoding the Mechanism of Action of Rapid-Acting Antidepressant Treatment Strategies: Does Gender Matter? International Journal of Molecular Sciences (Online), 20(4), Article 949. https://doi.org/10.3390/ijms20040949

Elfving, B., Müller, H. K., Oliveras, I., Østerbøg, T. B., Rio-Alamos, C., Sanchez-Gonzalez, A., Tobeña, A., Fernandez-Teruel, A. & Aznar, S. (2019). Differential expression of synaptic markers regulated during neurodevelopment in a rat model of schizophrenia-like behavior. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 95, Article 109669. https://doi.org/10.1016/j.pnpbp.2019.109669

Diniz, C. R. A. F., Biojone, C., Joca, S., Rantamäki, T., Castren, E., Guimaraes, F. S. & Casarotto, P. (2019). Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors. PeerJ, 7(2), Article e6493. https://doi.org/10.7717/peerj.6493

Pakkenberg, B., Olesen, M. V., Kaalund, S. S. & Dorph-Petersen, K.-A. (2019). Editorial: Neurostereology. Frontiers in Neuroanatomy, 13, Article 42. https://doi.org/10.3389/fnana.2019.00042

Köhler-Forsberg, O., Larsen, E. R., Buttenschøn, H. N., Rietschel, M., Hauser, J., Souery, D., Maier, W., Farmer, A., McGuffin, P., Aitchison, K. J., Uher, R. & Mors, O. (2019). Effect of antidepressant switching between nortriptyline and escitalopram after a failed first antidepressant treatment among patients with major depressive disorder. British Journal of Psychiatry, 215(2), 494-501. https://doi.org/10.1192/bjp.2018.302

Argyrousi, EK., Lagatta, DC., Schulutter, A., Weidner, MT., Zoller, J., van Goethem, NP., Joca, S., van den Hove, DLA. & Prickaerts, J. (2019). Effects of DNA methyltransferase inhibition on pattern separation performance in mice. Neurobiology of Learning and Memory, 159, 6-15. https://doi.org/10.1016/j.nlm.2019.02.003

Landau, A., Alstrup, A. K. O., Noer, O., Winterdahl, M., Audrain, H., Møller, A., Videbech, P., Wegener, G., Gjedde, A. & Doudet, D. J. (2019). Electroconvulsive stimulation differentially affects [¹¹C]MDL100,907 binding to cortical and subcortical 5HT_2A receptors in porcine brain. Journal of Psychopharmacology, 33(6), 714-721. Article 269881119836212. https://doi.org/10.1177/0269881119836212

Silote, G. P., Sartim, A., Sales, A., Eskelund, A., Guimarães, F. S., Wegener, G. & Joca, S. (2019). Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms. Journal of Chemical Neuroanatomy, 98, 104-116. https://doi.org/10.1016/j.jchemneu.2019.04.006

Mansouri, M., Pouretemad, H., Roghani, M., Wegener, G. & Ardalan, M. (2019). Environmental Enrichment Ameliorates Repetitive Behaviors in a Rat Model of Autism. Journal of Neurodevelopmental Cognition, 1, 108-117. http://jncog.sbu.ac.ir/issue/view/1326

Pereira, V. S., Joca, S. R. L., Harvey, B. H., Elfving, B. & Wegener, G. (2019). Esketamine and Rapastinel, but not Imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression. Acta Neuropsychiatrica, 31(5), 258-265. https://doi.org/10.1017/neu.2019.25

Treccani, G. (2019). From Structure to Behavior: Circuit Specificity of Stress-Induced Synaptic Plasticity in the Basolateral Amygdala Projection Neurons. Biological Psychiatry, 85(3), E7-E9. https://doi.org/10.1016/j.biopsych.2018.11.017

Normann, C. & Buttenschøn, H. N. (2019). Gene-environment interactions between HPA-axis genes and stressful life events in depression: A systematic review. Acta Neuropsychiatrica, 31(4), 186-192. https://doi.org/10.1017/neu.2019.16

Zhang, X., Abdellaoui, A., Rucker, J., de Jong, S., Potash, J. B., Weissman, M. M., Shi, J., Knowles, J. A., Pato, C., Pato, M., Sobell, J., Smit, J. H., Hottenga, J. J., de Geus, E. J. C., Lewis, C. M., Buttenschøn, H. N., Craddock, N., Jones, I., Jones, L. ... Levinson, D. F. (2019). Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts. Biological Psychiatry, 85(12), 1065-1073. https://doi.org/10.1016/j.biopsych.2019.02.022

Howard, D. M., Adams, M. J., Clarke, T.-K., Hafferty, J. D., Gibson, J., Shirali, M., Coleman, J. R. I., Hagenaars, S. P., Ward, J., Wigmore, E. M., Alloza, C., Shen, X., Barbu, M. C., Xu, E. Y., Whalley, H. C., Marioni, R. E., Porteous, D. J., Davies, G., Deary, I. J. ... 23andMe Research Team (2019). Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nature Neuroscience, 22(3), 343-352. https://doi.org/10.1038/s41593-018-0326-7

Winther, G., Eskelund, A., Richter, C. B., Elfving, B., Müller, H. K., Lund, S. & Wegener, G. (2019). Grandmaternal High-fat Diet Primed Anxiety-like Behaviour in the Second-Generation Female Offspring. Behavioural Brain Research, 359, 47-55. https://doi.org/10.1016/j.bbr.2018.10.017

Kirkedal, C., Elfving, B., Müller, H. K., Moreira, F. A., Bindila, L., Lutz, B., Wegener, G. & Liebenberg, N. (2019). Hemisphere-dependent endocannabinoid system activity in prefrontal cortex and hippocampus of the Flinders Sensitive Line rodent model of depression. Neurochemistry International, 125(May), 7-15. https://doi.org/10.1016/j.neuint.2019.01.023

Metaxas, A., Thygesen, C., Briting, S. R. R., Landau, A., Darvesh, S. & Finsen, B. (2019). Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer’s Disease Patients. Frontiers in Cellular Neuroscience, 13, Article 538. https://doi.org/10.3389/fncel.2019.00538

Rydbirk, R., Elfving, B., Folke, J., Pakkenberg, B., Winge, K., Brudek, T. & Aznar, S. (2019). Increased prefrontal cortex interleukin-2 protein levels and shift in the peripheral T cell population in progressive supranuclear palsy patients. Scientific Reports, 9(1), Article 7781. https://doi.org/10.1038/s41598-019-44234-y

Leonard, B. E. & Wegener, G. (2019). Inflammation, insulin resistance and neuroprogression in depression. Acta Neuropsychiatrica, 32(1), 1-9. https://doi.org/10.1017/neu.2019.17

Czamara, D., Eraslan, G., Page, C. M., Lahti, J., Lahti-Pulkkinen, M., Hämäläinen, E., Kajantie, E., Laivuori, H., Villa, P. M., Reynolds, R. M., Nystad, W., Håberg, S. E., London, S. J., O'Donnell, K. J., Garg, E., Meaney, M. J., Entringer, S., Wadhwa, P. D., Buss, C. ... Binder, E. B. (2019). Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nature Communications, 10, Article 2548. https://doi.org/10.1038/s41467-019-10461-0

Speed, M. S., Jefsen, O. H., Børglum, A. D., Speed, D. & Østergaard, S. D. (2019). Investigating the association between body fat and depression via Mendelian randomization. Translational Psychiatry, 9(1), Article 184. https://doi.org/10.1038/s41398-019-0516-4

Speed, D., Hemani, G., Speed, M. S., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & Børglum, A. D. (2019). Investigating the causal relationship between neuroticism and depression via Mendelian Randomization. Acta Psychiatrica Scandinavica, 139(4), 395-397. https://doi.org/10.1111/acps.13009

Kohtala, S., Theilmann, W., Rosenholm, M., Müller, H. K., Kiuru, P., Wegener, G., Yli-Kauhaluoma, J. & Rantamäki, T. (2019). Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites. Neuropharmacology, 157, 107684. Article 107684. https://doi.org/10.1016/j.neuropharm.2019.107684

Bay-Richter, C., Petersen, E., Liebenberg, N., Elfving, B. & Wegener, G. (2019). Latent toxoplasmosis aggravates anxiety- and depressive-like behaviour and suggest a role of gene-environment interactions in the behavioural response to the parasite. Behavioural Brain Research, 364(May), 133-139. https://doi.org/10.1016/j.bbr.2019.02.018

Bay-Richter, C., Buttenschøn, H. N., Mors, O., Eskelund, A., Budac, D., Kærlev, L. & Wegener, G. (2019). Latent toxoplasmosis and psychiatric symptoms - A role of tryptophan metabolism? Journal of Psychiatric Research, 110, 45-50. https://doi.org/10.1016/j.jpsychires.2018.12.016

Bannach-Brown, A., Przybyła, P., Thomas, J., Rice, A. S. C., Ananiadou, S., Liao, J. & Macleod, M. R. (2019). Machine learning algorithms for systematic review: Reducing workload in a preclinical review of animal studies and reducing human screening error. Systematic Reviews, 8(1), Article 23. https://doi.org/10.1186/s13643-019-0942-7

Khan, A. R., Hansen, B., Danladi, J., Chuhutin, A., Wiborg, O., Nyengaard, J. R. & Jespersen, S. (2019). Neurite atrophy in dorsal hippocampus of rat indicates incomplete recovery of chronic mild stress induced depression: Neurite atrophy in the hippocampus show partial recovery of depression. NMR in Biomedicine, 32(3), Article e4057. https://doi.org/10.1002/nbm.4057

Metaxas, A., Anzalone, M., Vaitheeswaran, R., Petersen, S., Landau, A. M. & Finsen, B. (2019). Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease. Alzheimer's Research & Therapy, 11(1), Article 38. https://doi.org/10.1186/s13195-019-0491-2

Pakkenberg, B., Olesen, M. V., Kaalund, S. S. & Dorph-Petersen, K.-A. (Eds.) (2019). Neurostereology. Frontiers Media. Frontiers Research Topics Frontiers in Neuroanatomy https://doi.org/10.3389/978-2-88945-880-6

Joca, S., Sartim, A., Roncalho, A., Diniz, C. & Wegener, G. (2019). Nitric oxide signalling and antidepressant action revisited. Cell and Tissue Research, 377(1), 45-58. https://doi.org/10.1007/s00441-018-02987-4

Smith, K. L., Cunningham, J. I., Eyerman, D. J., Dean, R. L., Deaver, D. R. & Sanchez, C. (2019). Opioid system modulators buprenorphine and samidorphan alter behavior and extracellular neurotransmitter concentrations in the Wistar Kyoto rat. Neuropharmacology, 146(March), 316-326. https://doi.org/10.1016/j.neuropharm.2018.11.015

Mansouri, M., Pouretemad, H., Roghani, M., Wegener, G. & Ardalan, M. (2019). Oxytocin improves autistic-like behaviors induced by maternal deprivation in female rats. DANESHVAR MEDICINE, 27(144 #T00275), 49-60. https://www.sid.ir/en/Journal/ViewPaper.aspx?ID=716476

Ribeiro, D. E., Roncalho, A. L., Glaser, T., Ulrich, H., Wegener, G. & Joca, S. (2019). P2X7 Receptor Signaling in Stress and Depression. International Journal of Molecular Sciences , 20(11), Article 2778. https://doi.org/10.3390/ijms20112778

Pereira, V. S., Suavinha, A. C. D. R., Wegener, G. & Joca, S. R. L. (2019). Prelimbic neuronal nitric oxide synthase inhibition exerts antidepressant-like effects independently of BDNF signalling cascades. Acta Neuropsychiatrica, 31(3), 143-150. https://doi.org/10.1017/neu.2018.39

Displaying results 1 to 50 out of 63

Revised 11.09.2025

Karen Jul Madsen