Publications 2021

2021

Abildgaard, A., Kern, T., Pedersen, O., Hansen, T., Lund, S. & Wegener, G. (2021). A diet-induced gut microbiota component and related plasma metabolites are associated with depressive-like behaviour in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 43, 10-21. https://doi.org/10.1016/j.euroneuro.2020.09.001

Bayraktar, G., Højgaard, K., Nijssen, L. & Takeuchi, T. (2021). A within-subject experimental design using an object location task in rats. Journal of Visualized Experiments, 2021(171), Article e62458. https://doi.org/10.3791/62458

Happ, D. F., Wegener, G. & Tasker, R. A. (2021). Behavioral and histopathological consequences of transient ischemic stroke in the Flinders Sensitive Line rat, a genetic animal model of depression. Brain Research, 1771, Article 147648. https://doi.org/10.1016/j.brainres.2021.147648

Silote, G. (2021). Behavioural and molecular effects induced by Cannabidiol in animal models of depression. [PhD dissertation, Aarhus University].

Dalby, R. B., Eskildsen, S. F., Videbech, P., Rosenberg, R. & Østergaard, L. (2021). Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder. Psychiatry Research - Neuroimaging, 317, Article 111383. https://doi.org/10.1016/j.pscychresns.2021.111383

Sartim, A. G., Marques, J., Silveira, K. M., Gobira, P. H., Guimarães, F. S., Wegener, G. & Joca, S. R. (2021). Co-administration of cannabidiol and ketamine induces antidepressant-like effects devoid of hyperlocomotor side-effects. Neuropharmacology, 195, Article 108679. https://doi.org/10.1016/j.neuropharm.2021.108679

Mikkelsen, A. C. D., Kjærgaard, K., Bay-Richter, C., Landau, A., Eriksen, P. L., Jalan, R., Hamilton-Dutoit, S. J., Chen, F., Vilstrup, H. V. A., Magnusson, N. E., Mookerjee, R. P. & Thomsen, K. L. (2021). Cognitive dysfunction is associated with systemic inflammation and neuroinflammation in a rodent model of NASH. Abstract from ISHEN 2021 SYMPOSIUM.

Al-Absi, A.-R., Qvist, P., Glerup, S., Sanchez, C. & Nyengaard, J. R. (2021). Df(h15q13)/+ Mouse Model Reveals Loss of Astrocytes and Synaptic-Related Changes of the Excitatory and Inhibitory Circuits in the Medial Prefrontal Cortex. Cerebral Cortex, 31(3), 1609-1621. https://doi.org/10.1093/cercor/bhaa313

Starnawska, A., Bukowski, L., Chernomorchenko, A., Elfving, B., Müller, H. K., van den Oord, E., Aberg, K., Guintivano, J., Grove, J., Mors, O., Børglum, A. D., Nielsen, A. L., Qvist, P. & Staunstrup, N. H. (2021). DNA methylation of the KLK8 gene in depression symptomatology. Clinical Epigenetics, 13(1), Article 200. https://doi.org/10.1186/s13148-021-01184-5

Mansouri, M., Pouretemad, H., Wegener, G., Roghani, M., Afshari, M., Mallard, C. & Ardalan, M. (2021). Dual Profile of Environmental Enrichment and Autistic-Like Behaviors in the Maternal Separated Model in Rats. International Journal of Molecular Sciences , 22(3), Article 1173. https://doi.org/10.3390/ijms22031173

Kaadt, E., Højgaard, K., Mumm, B., Christiansen, S. L., Müller, H. K., Damgaard, C. K. & Elfving, B. (2021). Dysregulation of miR-185, miR-193a, and miR-450a in the skin are linked to the depressive phenotype. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 104, Article 110052. https://doi.org/10.1016/j.pnpbp.2020.110052

Orso, R., Creutzberg, K. C., Lumertz, F. S., Wearick-Silva, L. E., Sanches, E. F., Mestriner, R. G., Wegener, G. & Grassi-Oliveira, R. (2021). Early environmental enrichment rescues memory impairments provoked by mild neonatal hypoxia-ischemia in adolescent mice. Behavioural Brain Research, 407, Article 113237. https://doi.org/10.1016/j.bbr.2021.113237

Treccani, G., Yigit, H., Lingner, T., Schleuβner, V., Mey, F., van der Kooij, M. A., Wennström, M., Herzog, D. P., Linke, M., Fricke, M., Schmeisser, M. J., Wegener, G., Mittmann, T., Trotter, J. & Müller, M. B. (2021). Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Na_v) channels properties. Neurobiology of Stress, 15, Article 100338. https://doi.org/10.1016/j.ynstr.2021.100338

Majdi, A., Sadigh-Eteghad, S. & Gjedde, A. (2021). Effects of transdermal nicotine delivery on cognitive outcomes: A meta-analysis. Acta Neurologica Scandinavica, 144(2), 179-191. https://doi.org/10.1111/ane.13436

Binda, K. H., Lillethorup, T. P., Real, C. C., Bærentzen, S. L., Nielsen, M. N., Orlowski, D., Brooks, D. J., Chacur, M. & Landau, A. M. (2021). Exercise protects synaptic density in a rat model of Parkinson's disease. Experimental Neurology, 342, 113741. Article 113741. https://doi.org/10.1016/j.expneurol.2021.113741

Marchisella, F., Creutzberg, K. C., Begni, V., Sanson, A., Wearick-Silva, L. E., Tractenberg, S. G., Orso, R., Kestering-Ferreira, É., Grassi-Oliveira, R. & Riva, M. A. (2021). Exposure to Prenatal Stress Is Associated With an Excitatory/Inhibitory Imbalance in Rat Prefrontal Cortex and Amygdala and an Increased Risk for Emotional Dysregulation. Frontiers in Cell and Developmental Biology, 9, Article 653384. https://doi.org/10.3389/fcell.2021.653384

Cristiano Real Gregório, C., Henrique Binda, K. & Landau, A. (2021). Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet: Treadmill exercise and neuroinflammation: Links with aging. In Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet: Treadmill exercise and neuroinflammation: Links with aging (pp. 385-401). Academic Press.

Knudsen, J. K., Michaelsen, T. Y., Bundgaard-Nielsen, C., Nielsen, R. E., Hjerrild, S., Leutscher, P., Wegener, G. & Sørensen, S. (2021). Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour. Scientific Reports, 11(1), Article 21869. https://doi.org/10.1038/s41598-021-01248-9

Treccani, G., Schlegelmilch, A. L., Schultz, N., Herzog, D. P., Bessa, J. M., Sotiropoulos, I., Müller, M. B. & Wennström, M. (2021). Hippocampal NG2+ pericytes in chronically stressed rats and depressed patients: a quantitative study. Stress, 24(3), 353-358. https://doi.org/10.1080/10253890.2020.1781083

Okuda, K., Højgaard, K., Privitera, L., Bayraktar, G. & Takeuchi, T. (2021). Initial memory consolidation and the synaptic tagging and capture hypothesis. The European journal of neuroscience, 54(8), 6826-6849. https://doi.org/10.1111/ejn.14902

Pingel, J., Pacolet, A., Elfving, B. & Ledri, L. N. (2021). Intramuscular BoNT/A injections cause an inflammatory response in the muscle tissue of rats. European Journal of Inflammation, 19. https://doi.org/10.1177/20587392211039942

Butler, H. M., Naseri, E., MacDonald, D. S., Tasker, R. A. & Ahmadi, A. (2021). Investigation of rheology, printability, and biocompatibility of N,O-carboxymethyl chitosan and agarose bioinks for 3D bioprinting of neuron cells. Materialia, 18, Article 101169. https://doi.org/10.1016/j.mtla.2021.101169

Andersen, O. M., Bøgh, N., Landau, A., Pløen, G. G., Jensen, A. M. G., Monti, G., Ulhøi, B. P., Nyengaard, J. R., Jacobsen, K. R., Jørgensen, M. M., Holm, I. E., Kristensen, M. L., Søvsø Szocska Hansen, E., Teunissen, C. E., Breidenbach, L., Droescher, M., Liu, Y., Pedersen, H. S., Callesen, H. ... Sørensen, C. B. (2021). In vivo evidence that SORL1, encoding the endosomal recycling receptor SORLA, can function as a causal gene in Alzheimer´s Disease. http://biorxiv.org/content/early/2021/07/13/2021.07.13.452149

Thomsen, M., Jacobsen, J., Lillethorup, T. P., Schacht, A. C., Simonsen, M. I. T., Romero-Ramos, M., Brooks, D. J. & Landau, A. (2021). In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET. Journal of Cerebral Blood Flow and Metabolism, 41(4), 819-830. https://doi.org/10.1177/0271678X20931140

Herzog, D. P., Perumal, N., Manicam, C., Treccani, G., Nadig, J., Rossmanith, M., Engelmann, J., Jene, T., Hasch, A., van der Kooij, M. A., Lieb, K., Gassen, N. C., Grus, F. H. & Müller, M. B. (2021). Longitudinal CSF proteome profiling in mice to uncover the acute and sustained mechanisms of action of rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK). Neurobiology of Stress, 15, Article 100404. https://doi.org/10.1016/j.ynstr.2021.100404

Kestering-Ferreira, E., Tractenberg, S. G., Lumertz, F. S., Orso, R., Creutzberg, K. C., Wearick-Silva, L. E., Viola, T. W. & Grassi-Oliveira, R. (2021). Long-term Effects of Maternal Separation on Anxiety-Like Behavior and Neuroendocrine Parameters in Adult Balb/c Mice. Chronic Stress, 5. https://doi.org/10.1177/24705470211067181

Sales, A. J., Maciel, I. S., Suavinha, A. C. D. R. & Joca, S. R. L. (2021). Modulation of DNA Methylation and Gene Expression in Rodent Cortical Neuroplasticity Pathways Exerts Rapid Antidepressant-Like Effects. Molecular Neurobiology, 58(2), 777–794. https://doi.org/10.1007/s12035-020-02145-4

Sampaio, A. S. B., Real, C. C., Gutierrez, R. M. S., Singulani, M. P., Alouche, S. R., Britto, L. R. & Pires, R. S. (2021). Neuroplasticity induced by the retention period of a complex motor skill learning in rats. Behavioural Brain Research, 414, Article 113480. https://doi.org/10.1016/j.bbr.2021.113480

Vibholm, A. K., Landau, A. M., Møller, A., Jacobsen, J., Vang, K., Munk, O. L., Orlowski, D., Sorensen, J. C. H. & Brooks, D. J. (2021). NMDA receptor ion channel activation detected in vivo with [¹⁸F]GE-179 PET after electrical stimulation of rat hippocampus. Journal of Cerebral Blood Flow and Metabolism, 41(6), 1301-1312. https://doi.org/10.1177/0271678X20954928

Baptista, T., de Azeredo, L. A., Zaparte, A., Viola, T. W., Coral, S. C., Nagai, M. A., Mangone, F. R., Pavanelli, A. C., Schuch, J. B., Mardini, V., Szobot, C. M. & Grassi-Oliveira, R. (2021). Oxytocin Receptor Exon III Methylation in the Umbilical Cord Blood of Newborns With Prenatal Exposure to Crack Cocaine. Frontiers in Cell and Developmental Biology, 9, Article 639287. https://doi.org/10.3389/fcell.2021.639287

Thomsen, M. B., Ferreira, S. A., Schacht, A. C., Jacobsen, J., Simonsen, M., Betzer, C., Jensen, P. H., Brooks, D. J., Landau, A. M. & Romero-Ramos, M. (2021). PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats. Neurobiology of Disease, 149, Article 105229. https://doi.org/10.1016/j.nbd.2020.105229

Schou, T. M., Joca, S., Wegener, G. & Bay-Richter, C. (2021). Psychiatric and neuropsychiatric sequelae of COVID-19 - A systematic review. Brain, Behavior, and Immunity, 97, 328-348. https://doi.org/10.1016/j.bbi.2021.07.018

Joca, S., Silote, G., Sartim, A., Sales, A. J., Guimarães, F. S. & Wegener, G. (2021). Putative effects of cannabidiol in depression and synaptic plasticity. In C. R. Martin, L.-A. Hunter, V. B. Patel, V. R. Preedy & R. Rajendram (Eds.), The Neuroscience of Depression: Features, Diagnosis and Treatment (Vol. Part V, pp. 459-467). Academic Press. https://doi.org/10.1016/B978-0-12-817933-8.00052-9

Faber, J., Eldrup, E., Selmer, C., Pichat, C., Hecquet, S. K., Watt, T., Kreiner, S., Karpatschof, B., Gyntelberg, F., Ballegaard, S. & Gjedde, A. (2021). Reduction of Pressure Pain Sensitivity as Novel Non-pharmacological Therapeutic Approach to Type 2 Diabetes: A Randomized Trial. Frontiers in Neuroscience, 15, Article 613858. https://doi.org/10.3389/fnins.2021.613858

Henriksen, O. M., Gjedde, A., Vang, K., Law, I., Aanerud, J. & Rostrup, E. (2021). Regional and interindividual relationships between cerebral perfusion and oxygen metabolism. Journal of Applied Physiology, 130(6), 1836-1847. https://doi.org/10.1152/japplphysiol.00939.2020

Jabbari, M., Ardalan, M., Bay, V., Safi, A., Afsharpour, R., Chumak, Tasker, Malard, C. & Wegener, G. (2021). Role of hippocampal neuroinflammation in the resistance to brain infarction in a genetic animal model of depression. Poster session presented at The Brain Prize Meeting 2021, Denmark.

Terstege, D. J., MacDonald, D. S. & Tasker, R. A. (2021). Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test. Acta Neuropsychiatrica, 33(3), 141-147. https://doi.org/10.1017/neu.2021.2

Silote, G. P., Gatto, M. C., Eskelund, A., Guimarães, F. S., Wegener, G. & Joca, S. R. L. (2021). Strain-, sex-, and time-dependent antidepressant-like effects of cannabidiol. Pharmaceuticals, 14(12), Article 1269. https://doi.org/10.3390/ph14121269

Kuebler, L., Buss, S., Leonov, A., Ryazanov, S., Schmidt, F., Maurer, A., Weckbecker, D., Landau, A. M., Lillethorup, T. P., Bleher, D., Saw, R. S., Pichler, B. J., Griesinger, C., Giese, A. & Herfert, K. (2021). [¹¹C]MODAG-001-towards a PET tracer targeting α-synuclein aggregates. European Journal of Nuclear Medicine and Molecular Imaging, 48(6), 1759–1772 . https://doi.org/10.1007/s00259-020-05133-x

Silveira, K. M., Wegener, G. & Joca, S. R. L. (2021). Targeting 2-arachidonoylglycerol signalling in the neurobiology and treatment of depression. Basic & Clinical Pharmacology & Toxicology, 129(1), 3-14. https://doi.org/10.1111/bcpt.13595

Ferreira, A. F. F., Binda, K. H. & Real, C. C. (2021). The effects of treadmill exercise in animal models of Parkinson's disease: A systematic review. Neuroscience and Biobehavioral Reviews, 131, 1056-1075. https://doi.org/10.1016/j.neubiorev.2021.10.019

Tillmann, S., Awwad, H. M., MacPherson, C. W., Happ, D. F., Treccani, G., Geisel, J., Tompkins, T. A., Ueland, P. M., Wegener, G. & Obeid, R. (2021). The kynurenine pathway is upregulated by methyl-deficient diet and changes are averted by probiotics. Molecular Nutrition & Food Research, 65(9), e2100078. Article 2100078. https://doi.org/10.1002/mnfr.202100078

Chen, F., Danladi, J., Ardalan, M., Nyengaard, J. R., Sánchez, C. & Wegener, G. (2021). The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine. European Neuropsychopharmacology, 42, 45-56. https://doi.org/10.1016/j.euroneuro.2020.11.008

Bay, V., Iversen, N. K., Jabbari, M., Tasker, A., Wegener, G. & Ardalan, M. (2021). Tissue processing and optimal visualization of cerebral infarcts following sub-acute focal ischemia in rats. Journal of Chemical Neuroanatomy, 118, Article 102034. https://doi.org/10.1016/j.jchemneu.2021.102034

Jefsen, O. H., Elfving, B., Wegener, G. & Müller, H. K. (2021). Transcriptional regulation in the rat prefrontal cortex and hippocampus after a single administration of psilocybin. Journal of Psychopharmacology, 35(4), 483-493. https://doi.org/10.1177/0269881120959614

Miles, A. E., Dos Santos, F. C., Byrne, E. M., Renteria, M. E., McIntosh, A. M., Adams, M. J., Pistis, G., Castelao, E., Preisig, M., Baune, B. T., Schubert, K. O., Lewis, C. M., Jones, L. A., Jones, I., Uher, R., Smoller, J. W., Perlis, R. H., Levinson, D. F., Potash, J. B. ... Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2021). Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk. Neuropsychopharmacology, 46(13), 2304-2311. https://doi.org/10.1038/s41386-021-01189-x

Bauer, M., Glenn, T., Achtyes, E. D., Alda, M., Agaoglu, E., Altınbaş, K., Andreassen, O. A., Angelopoulos, E., Ardau, R., Vares, E. A., Aydin, M., Ayhan, Y., Baethge, C., Bauer, R., Baune, B. T., Balaban, C., Becerra-Palars, C., Behere, A. P., Behere, P. B. ... Whybrow, P. C. (2021). Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder. International Journal of Bipolar Disorders, 9(1), Article 26. https://doi.org/10.1186/s40345-021-00231-7

Martis, L.-S., Højgaard, K., Holmes, M. C., Elfving, B. & Wiborg, O. (2021). Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task. Scientific Reports, 11(1), 9113. Article 9113. https://doi.org/10.1038/s41598-021-88462-7

Tondo, L. P., Viola, T. W., Fries, G. R., Kluwe-Schiavon, B., Rothmann, L. M., Cupertino, R., Ferreira, P., Franco, A. R., Lane, S. D., Stertz, L., Zhao, Z., Hu, R., Meyer, T., Schmitz, J. M., Walss-Bass, C. & Grassi-Oliveira, R. (2021). White matter deficits in cocaine use disorder: convergent evidence from in vivo diffusion tensor imaging and ex vivo proteomic analysis. Translational Psychiatry, 11(1), Article 252. https://doi.org/10.1038/s41398-021-01367-x

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Revised 31.01.2023

Karen Jul Madsen