Publications 2017

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Khanmohammadi, M., Darkner, S., Nava, N., Nyengaard, J. R., Wegener, G., Popoli, M. & Sporring, J. (2017). 3D analysis of synaptic vesicle density and distribution after acute foot-shock stress by using serial section transmission electron microscopy. Journal of Microscopy, 265(1), 101–110. https://doi.org/10.1111/jmi.12468

Wegener, G. (2017). Acta Neuropsychiatrica and social media. Acta Neuropsychiatrica, 29(6), 323. https://doi.org/10.1017/neu.2017.30

Kirkedal, C., Wegener, G., Moreira, F., Joca, S. R. L. & Liebenberg, N. (2017). A dual inhibitor of FAAH and TRPV1 channels shows dose-dependent effect on depression-like behaviour in rats. Acta Neuropsychiatrica, 29(6), 324-329. https://doi.org/10.1017/neu.2016.68

Johansson, H. K. L., Hansen, J. S., Elfving, B., Lund, S. P., Kyjovska, Z. O., Loft, S., Barfod, K. K., Jackson, A. P., Vogel, U. & Hougaard, K. S. (2017). Airway exposure to multi-walled carbon nanotubes disrupts the female reproductive cycle without affecting pregnancy outcomes in mice. Particle and Fibre Toxicology, 14(1), 17. Article 17. https://doi.org/10.1186/s12989-017-0197-1

Aberg, K. A., Chan, RF., Shabalin, AA., Zhao, M., Turecki, G., Staunstrup, N. H., Starnawska, A., Mors, O., Xi, LY. & van den Oord, E. J. C. G. (2017). A MBD-seq protocol for large-scale methylome-wide studies with (very) low amounts of DNA. Epigenetics, 12(9), 743-750. https://doi.org/10.1080/15592294.2017.1335849

Buttenschøn, H. N., Krogh, J., Nielsen, M. N., Nordentoft, M. & Mors, O. (2017). Association analyses of depression and genes in the hypothalamus-pituitary-adrenal axis. Acta Neuropsychiatrica, 29(1), 59-64. https://doi.org/10.1017/neu.2016.26

Köhler-Forsberg, O., Buttenschøn, H. N., Tansey, K. E., Maier, W., Hauser, J., Dernovsek, M. Z., Henigsberg, N., Souery, D., Farmer, A., Rietschel, M., McGuffin, P., Aitchison, K. J., Uher, R. & Mors, O. (2017). Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression. Brain, Behavior, and Immunity, 62, 344-350. https://doi.org/10.1016/j.bbi.2017.02.020

Treccani, G., Ardalan, M., Chen, F., Musazzi, Bettega, Mikkelsen, Popoli, M., Wegener, G., Nyengaard, J. R. & Müller, H. K. (2017). Behavioural and hippocampal morphological changes induced by short ketamine treatment in a genetic rat model displaying depressive-like behaviour. Abstract from European Neuropsychopharmacology.

Eskelund, A. (2017). Characterization of tryptophan metabolites in depression and recovery. Aarhus Universitet, Health.

Varga, Z., Csabai, D., Miseta, A., Wiborg, O. & Czeh, B. (2017). Chronic stress affects the number of GABAergic neurons in the orbitofrontal cortex of rats. Behavioural Brain Research, 316, 104-114. https://doi.org/10.1016/j.bbr.2016.08.030

Hatherall, L., Sanchez, C. & Morilak, D. A. (2017). Chronic Vortioxetine Treatment Reduces Exaggerated Expression of Conditioned Fear Memory and Restores Active Coping Behavior in Chronically Stressed Rats. International Journal of Neuropsychopharmacology, 20(4), 316-323. https://doi.org/10.1093/ijnp/pyw105

Christiansen, S. L. & Bouzinova, E. (2017). Clock genes in depression. In D. Breznoščáková (Ed.), Depression InTechOpen. https://doi.org/10.5772/63698

Mellerup, E., Andreassen, O. A., Bennike, B., Dam, H., Djurovic, S., Jorgensen, M. B., Kessing, L. V., Koefoed, P., Melle, I., Mors, O. & Moeller, G. L. (2017). Combinations of genetic variants associated with bipolar disorder. PLoS One, 12(12), e0189739. Article e0189739. https://doi.org/10.1371/journal.pone.0189739

Rydbirk, R., Elfving, B., Andersen, M. D., Langbøl, M. A., Folke, J., Winge, K., Pakkenberg, B., Brudek, T. & Aznar, S. (2017). Cytokine profiling in the prefrontal cortex of Parkinson's Disease and Multiple System Atrophy patients. Neurobiology of Disease, 106, 269-278. https://doi.org/10.1016/j.nbd.2017.07.014

Stein, D. J. & Wegener, G. (2017). Discovery versus implementation research on mental disorders in low- and middle-income countries. Acta Neuropsychiatrica, 29(4), 191-192. https://doi.org/10.1017/neu.2017.25

Eskelund, A., Li, Y., Budac, D. P., Müller, H. K., Gulinello, M., Sanchez, C. & Wegener, G. (2017). Drugs with antidepressant properties affect tryptophan metabolites differently in rodent models with depression-like behavior. Journal of Neurochemistry, 142(1), 118-131. https://doi.org/10.1111/jnc.14043

Phan, J.-A., Stokholm, K., Zareba-Paslawska, J., Jakobsen, S., Vang, K., Gjedde, A., Landau, A. M. & Romero-Ramos, M. (2017). Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson's disease. Scientific Reports, 7(1), Article 6363. https://doi.org/10.1038/s41598-017-06724-9

Déziel, R. A. & Tasker, R. A. (2017). Effects of endothelin-induced prefrontal cortical lesions on delay discounting in the rat. Behavioral Neuroscience, 131(1), 11-19. https://doi.org/10.1037/bne0000179

Csabai, D., Seress, L., Varga, Z., Abraham, H., Miseta, A., Wiborg, O. & Czeh, B. (2017). Electron Microscopic Analysis of Hippocampal Axo-Somatic Synapses in a Chronic Stress Model for Depression. The Hippocampus, 27(1), 17-27. https://doi.org/10.1002/hipo.22650

Ventorp, F., Bay-Richter, C., Nagendra, A., Janelidze, S., Matsson, V., Lipton, J., Nordström, U., Westrin, Å., Brundin, P. & Brundin, L. (2017). Exendin-4 Treatment Improves LPS-Induced Depressive-Like Behavior Without Affecting Pro-Inflammatory Cytokines. Journal of Parkinson's Disease, 7(2), 263-273. https://doi.org/10.3233/JPD-171068

du Jardin, K. G., Müller, H. K., Sanchez, C., Wegener, G. & Elfving, B. (2017). Gene expression related to serotonergic and glutamatergic neurotransmission is altered in the Flinders Sensitive Line rat model of depression: Effect of ketamine. Synapse, 71(1), 37–45. https://doi.org/10.1002/syn.21940

Bigdeli, T. B., Ripke, S., Peterson, R. E., Trzaskowski, M., Bacanu, S.-A., Abdellaoui, A., Andlauer, T. F. M., Beekman, A. T. F., Berger, K., Blackwood, D. H. R., Boomsma, D. I., Breen, G., Buttenschøn, H. N., Byrne, E. M., Cichon, S., Clarke, T.-K., Couvy-Duchesne, B., Craddock, N., de Geus, E. J. C. ... Kendler, K. S. (2017). Genetic effects influencing risk for major depressive disorder in China and Europe. Translational Psychiatry, 7(3), e1074. Article e1074. https://doi.org/10.1038/tp.2016.292

Power, R. A., Tansey, K. E., Buttenschøn, H. N., Cohen-Woods, S., Bigdeli, T., Hall, L. S., Kutalik, Z., Lee, S. H., Ripke, S., Steinberg, S., Teumer, A., Viktorin, A., Wray, N. R., Arolt, V., Baune, B. T., Boomsma, D. I., Børglum, A. D., Castelao, E., Craddock, N. ... CONVERGE Consortium, CARDIoGRAM Consortium, GERAD1 Consortium (2017). Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Biological Psychiatry, 81(4), 325–335. https://doi.org/10.1016/j.biopsych.2016.05.010

CORtisolNETwork (CORNET) Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC) & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC) (2017). Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes. Scientific Reports, 7(1), Article 15351. https://doi.org/10.1038/s41598-017-11852-3

Chakroborty, S., Geisbush, T. R., Dale, E., Pehrson, A. L., Sanchez, C. & West, A. R. (2017). Impact of Vortioxetine on Synaptic Integration in Prefrontal-Subcortical Circuits: Comparisons with Escitalopram. Frontiers in Pharmacology, 8(OCT), Article 764. https://doi.org/10.3389/fphar.2017.00764

Antila, H., Ryazantseva, M., Popova, D., Sipilä, P., Guirado, R., Kohtala, S., Yalcin, I., Lindholm, J., Vesa, L., Sato, V., Cordeira, J., Autio, H., Kislin, M., Rios, M., Joca, S., Casarotto, P., Khiroug, L., Lauri, S., Taira, T. ... Rantamäki, T. (2017). Isoflurane produces antidepressant effects and induces TrkB signaling in rodents. Scientific Reports, 7(1), 7811. Article 7811. https://doi.org/10.1038/s41598-017-08166-9

Sinning, S. & Lund, A. E. (2017). Jungle Brew and Depression:Molecular Pharmacology of Ayahuasca Alkaloids on Monoamine Transporter Systems. Poster session presented at 9th Annual Meeting of the Danish Society of Pharmacology, Odense, Denmark.

Silva Pereira, V., Elfving, B., Joca, S. R. L. & Wegener, G. (2017). Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats. European Journal of Pharmacology, 815, 304-311. https://doi.org/10.1016/j.ejphar.2017.09.029

Qvist, P., Rajkumar, A. P., Redrobe, J. P., Nyegaard, M., Christensen, J. H., Mors, O., Wegener, G., Didriksen, M. & Børglum, A. D. (2017). Mice heterozygous for an inactivated allele of the schizophrenia associated Brd1 gene display selective cognitive deficits with translational relevance to schizophrenia. Neurobiology of Learning and Memory, 141, 44-52. https://doi.org/10.1016/j.nlm.2017.03.009

Tillmann, S. (2017). Mind the gap – towards complete and transparent reporting of animal research. Medical Writing, 26(4), 24-27. http://journal.emwa.org/preclinical-studies/mind-the-gap-towards-complete-and-transparent-reporting-of-animal-research/

Lillethorup, T. P., GLUD, AN., Jakobsen, S., Alstrup, A. K. O., Moeller, A., Sørensen, J. C. H., Doudet, D. J. & Landau, A. M. (2017). Multi-Neurotransmitter Deficits in a Minipig Model of Parkinson’s Disease. Poster session presented at 1st Annual Research Meeting, Aarhus, Denmark.

Hangaard, L., Bouzinova, E., Stæhr, C. A., Dam, V. S., Kim, S., Xie, Z., Aalkjær, C. & Matchkov, V. (2017). Na,K-ATPase regulates intercellular communication in the vascular wall via cSrc kinase dependent connexin43 phosphorylation. American Journal of Physiology: Cell Physiology, 4(312), C385-C397. https://doi.org/10.1152/ajpcell.00347.2016

Febbraro, F., Svenningsen, K., Thao Phuong Tran & Wiborg, O. (2017). Neuronal substrates underlying stress resilience and susceptibility in rats. PLoS One, 12(6), Article 0179434. https://doi.org/10.1371/journal.pone.0179434

Olesen, L. O., Sivasaravanaparan, M., Severino, M., Babcock, A. A., Bouzinova, E. V., West, M. J., Wiborg, O. & Finsen, B. (2017). Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APP(swe)/PS1(dE9) transgenic mice: Effect of long-term treatment with paroxetine. Neurobiology of Disease, 104, 50-60. https://doi.org/10.1016/j.nbd.2017.04.021

Waller, J. A., Nygaard, S. H., Li, Y., du Jardin, K. G., Tamm, J. A., Abdourahman, A., Elfving, B., Pehrson, A. L., Sánchez, C. & Wernersson, R. (2017). Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents. BMC Neuroscience, 18(1), 56. Article 56. https://doi.org/10.1186/s12868-017-0376-x

Sales, A. J., Hiroaki-Sato, V. A. & Joca, S. R. L. (2017). Participation of hippocampal nitric oxide synthase and soluble guanylate cyclase in the modulation of behavioral responses elicited by the rat forced swimming test. Behavioural Pharmacology, 28(1), 19-29. https://doi.org/10.1097/FBP.0000000000000263

García-González, J., Tansey, K. E., Hauser, J., Henigsberg, N., Maier, W., Mors, O., Placentino, A., Rietschel, M., Souery, D., Žagar, T., Czerski, P. M., Jerman, B., Buttenschøn, H. N., Schulze, T. G., Zobel, A., Farmer, A., Aitchison, K. J., Craig, I., McGuffin, P. ... Major Depressive Disorder Working Group of the Psychiatric Genomic Consortium (2017). Pharmacogenetics of antidepressant response: A polygenic approach. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 75, 128-134. https://doi.org/10.1016/j.pnpbp.2017.01.011

Campos, A. C., Fogaça, M. V., Scarante, F. F., Joca, S. R. L., Sales, A. J., Gomes, F. V., Sonego, A. B., Rodrigues, N. S., Galve-Roperh, I. & Guimarães, F. S. (2017). Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders. Frontiers in Pharmacology, 8(MAY), 269. Article 269. https://doi.org/10.3389/fphar.2017.00269

Dorph-Petersen, K.-A. & Lewis, D. A. (2017). Postmortem structural studies of the thalamus in schizophrenia. Schizophrenia Research, 180, 28-35. https://doi.org/10.1016/j.schres.2016.08.007

Abildgaard, A., Elfving, B., Hokland, M., Lund, S. & Wegener, G. (2017). Probiotic treatment protects against the pro-depressant-like effect of high-fat diet in Flinders Sensitive Line rats. Brain, Behavior, and Immunity, 65, 33-42. https://doi.org/10.1016/j.bbi.2017.04.017

Abildgaard, A., Elfving, B., Hokland, M., Wegener, G. & Lund, S. (2017). Probiotic treatment reduces depressive-like behaviour in rats independently of diet. Psychoneuroendocrinology, 79, 40-48. https://doi.org/10.1016/j.psyneuen.2017.02.014

Buttenschøn, H. N., Nielsen, M. N., Thotakura, G., Lee, C. W., Nykjær, A., Mors, O. & Glerup, S. (2017). Progranulin gene variation affects serum progranulin levels differently in Danish bipolar individuals compared with healthy controls. Psychiatric Genetics, 27(3), 89-95. https://doi.org/10.1097/YPG.0000000000000168

Bernard, P. B., Ramsay, L. A., MacDonald, D. S. & Tasker, R. A. (2017). Progressive changes in hippocampal cytoarchitecture in a neurodevelopmental rat model of epilepsy: implications for understanding presymptomatic epileptogenesis, predictive diagnosis, and targeted treatments. The EPMA journal, 8(3), 247-254. https://doi.org/10.1007/s13167-017-0111-9

Phan, J.-A., Landau, A. M., Jakobsen, S. & Gjedde, A. (2017). Radioligand binding analysis of α 2 adrenoceptors with [11C]yohimbine in brain in vivo: Extended Inhibition Plot correction for plasma protein binding. Scientific Reports, 7(7), Article 15979. https://doi.org/10.1038/s41598-017-16020-1

Ardalan, M., Rafati, A. H., Nyengaard, J. R. & Wegener, G. (2017). Rapid Antidepressant Effect of Ketamine Correlates with Astroglial Plasticity in the Hippocampus. British Journal of Pharmacology, 174(6), 483-492. https://doi.org/10.1111/bph.13714

Bahor, Z., Liao, J., Macleod, M., Bannach-Brown, A., McCann, S. K., Wever, K. E., Thomas, J., Ottavi, T., Howells, D. W., Rice, A., Ananiadou, S. & Sena, E. (2017). Risk of bias reporting in the recent animal focalcerebral ischaemia literature. Clinical Science, 131(20), 2525-2532. https://doi.org/10.1042/CS20160722

Haase, J., Grudzinska-Goebel, J., Müller, H. K., Münster-Wandowski, A., Chow, E., Wynne, K., Farsi, Z., Zander, J.-F. & Ahnert-Hilger, G. (2017). Serotonin Transporter Associated Protein Complexes Are Enriched in Synaptic Vesicle Proteins and Proteins Involved in Energy Metabolism and Ion Homeostasis. ACS Chemical Neuroscience, 8(5), 1101-1116. https://doi.org/10.1021/acschemneuro.6b00437

Ardalan, M., Wegener, G., H Rafati, A. & R Nyengaard, J. (2017). S-Ketamine Rapidly Reverses Synaptic and Vascular Deficits of Hippocampus in Genetic Animal Model of Depression. International Journal of Neuropsychopharmacology, 20(3), 247-256. https://doi.org/10.1093/ijnp/pyw098

Mothes, L., Kristensen, C. H., Oliveira, R. G., Argimon, I. I. D. L., Fonseca, R. P. & Irigaray, T. Q. (2017). Stressful events and executive functioning in adolescents with and without history of grade repetition. Universitas Psychologica, 16(4), 1-12. https://doi.org/10.11144/Javeriana.upsy16-4.seef