microPET
Through close and longstanding collaboration with the Department of Nuclear Medicine and PET Center at Aarhus University Hospital, we are conducting radioligand binding studies.
The equipment can be found at the PET Preclinical Facility at Aarhus University Hospital
Why we use it
• Allows for non-invasive in vivo imaging of rodent models
• Integrates high-resolution Positron Emission Tomography (PET) (0.7mm) with Magnetic Resonance Imaging (MRI) (1 Tesla), providing comprehensive anatomical and functional imaging for preclinical research
• Use of short-lived PET ligands, labeled with 11C or 18F by dedicated radiochemists using on-site cyclotrons, designed to target and visualise specific molecular processes
• The same ligands can be used in human imaging, underscoring the method’s translational value
Equipment
• Mediso Nanoscan PET/MRI scanner for small laboratory animals
• https://mediso.com/hungary/en/product/pre-clinical-products/nanoscanr-petmri-3t-and-7t (please note, we have the 1T MRI version)
• Department of Nuclear Medicine and PET Center at Aarhus University Hospital
Applications in Translational Neuroimaging
• In vivo assessment of monoamine neurotransmission, protein aggregation, neuroinflammation, presynaptic density, glucose metabolism, and more
• Longitudinal studies to examine disease progression and the acute and chronic effects of potential therapies
• Drug challenge studies to investigate neurotransmitter release
• Trials of novel PET ligands developed by PET Center radiochemists