Our current research focuses on understanding the molecular mechanisms controlling proteolytic processing of amyloid precursor protein, p75NTR and sortilin in neurodegenerative and neuropsychiatric disorders and evaluating potential approaches to target these processes for therapeutic purposes. We are particularly interested in regulatory mechanisms of ectodomain shedding mediated by protein-protein interactions and processes modulated by membrane cholesterol levels.
A second topic of research interest is molecular mechanisms contributing to fast-acting antidepressant effects of ketamine and psychedelics. Studies include receptor signaling, trafficking, and protein-protein interactions.
Current research activities:
We aim to discover molecular targets and mechanisms that can be translated into novel therapeutic strategies for neuropsychiatric and neurodegenerative disorders.
We have projects available for Master, PhD, and Research Year students. The projects are particularly relevant for students with a background in molecular biology, molecular medicine, medicinal chemistry or medicine. We support collaborative projects within our unit as well as collaborations with external groups.
Please contact Heidi Kaastrup Müller (firstname.lastname@example.org) for further information.