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Translational Neuropsychiatry Unit

PhD dissertations

2018

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Winther, G. (2018). Early Life Programming of Brain and Behaviour. Aarhus University.

Tillmann, S. (2018). Impact of gut microbiota modulation on host behavior and metabolism. Aarhus University.

Bay, V. (2018). Novel approaches to modeling pre-stroke depression in the rat. Aarhus University.

Martis, L-S. (2018). Translational assessment of cognitive impairments in depression models. Aarhus University & University of Edinburg.

Bannach-Brown, A. (2018). Understanding In Vivo Modelling of Depression. Aarhus University.

2017

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Eskelund, A. (2017). Characterization of tryptophan metabolites in depression and recovery. Aarhus: Aarhus Universitet, Health.

2016

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Christiansen, S. L. (2016). Chronobiology in the Chronic Mild Stress Animal Model of Depression. Health, Aarhus University.

Abildgaard, A. (2016). Preclinical Studies on Metabolic Stress and Probiotic Treatment in Major Depressive Disorder. Health, Aarhus University.

Ardalan, M. (2016). The Influence of Rapid-acting Antidepressants on the Neuronal and Non-neuronal Plasticity of the Hippocampus in a Genetic Rat Model of Depression. Aarhus University.

du Jardin, K. G. (2016). Unlocking the Antidepressant Potential of the Serotonergic-Glutamatergic Crosstalk. Faculty of Health Sciences, Aarhus University.

2015

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Fischer, C. (2015). Challenging the immune system in rodents and its association to depression.

Gregersen, N. (2015). Identification and analyses of genetic risk factors for panic disorder.

2014

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Foldager, L. (2014). A statistical perspective on association studies of psychiatric disorders: Genetic effects of single-markers, haplotypes, gene-environment interactions and gene-gene interactions. Health, Aarhus University.

2013

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Devantier, T. A. (2013). Aspects of Cardiovascular Disease in Depression. Faculty of Health Science, Aarhus Universitet.

Austin, S. (2013). Long term outcomes and course of illness in first episode psychosis: Predictors of recovery, trajectories of symptoms and metacognition. A 10 year follow-up study of the OPUS cohort. Faculty of Health Science, Aarhus Universitet.

2012

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Bisgaard, C. (2012). Comparative proteomics in a chronic mild stress rat model of depression - fingerprints of stress reactivity and treatment response. Det Sundhedsvidenskabelige Fakultet, Aarhus Universitet.

Henningsen, K. (2012). The neural basis of cognitive deficits studied in the chronic mild stress rat model of depression. Aarhus Universitet.

2011

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Severinsen, K. (2011). Ligand Binding to the Serotonin Transporter and its functional aspects. Århus Universitet.

2010

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Christensen, T. (2010). Gene Expression profiling study in a rat chronic mild stress model of depression. Faculty of Health Sciences, Aarhus University.

Madsen, J. A. (2010). MRI Cerebral Morphometry: Tools for the study of neuro-degenerative diseases.

Kjær, S. L. (2010). Stress during fetal life and acousitc startle response changes in adult rat offspring. Aarhus Universitet: Faculty of Health Sciences, Aarhus University.

Liebenberg, N. (2010). The inhibition of phosphodiesterase type 5 as a novel target for antidepressant action.

2009

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Dalby, R. B. (2009). MRI-defined cerebral white matter lesions in late-onset major depression. Faculty of Health Sciences, Aarhus University.

Hviid, L. B. (2009). Visuospatial Navigation and Hippocampal Function Remitted Depressed Patients. Aarhus Universitet: SUN-TRYK, Aarhus Universitet.

2008

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Madsen, M. M. L. (2008). Attitudes towards psychiatric genetics among future users and providers of psychiatric genetic testing and counselling. <Forlag uden navn>.

Ashkanian, M. (2008). Carbogen Inhalation Increases Oxygen Transport to Brain Tissue. Denmark: University of Aarhus.

Arendt, M. (2008). Comorbidity between cannabis use and psychiatric disorders. University of Aarhus.

Fjorback, A. W. (2008). Regulation and trafficking of the monoamine transporters. University of Aarhus.

Kristensen, A. S. (2008). The structure of anxiety symptoms. An investigation of the factor structure of anxiety symptoms in panic disorder and social phobia and the relationship between symptom dimensions and personality. University of Aarhus.

2007

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Buttenschøn, H. N. (2007). Glutamate decarboxylase 1 as a suspectibility gene for autism, bipolar affective disorder and schizophrenia. Faculty of Health Sciences, University of Aarhus.

Hasselstrøm, J. (2007). Metabolism and therapeutic drug monitoring of quetiapine. Faculty of Health Science, University of Aarhus.

Bonefeld, B. (2007). Molecular Mechanisms in Treatment and Pathology of Depression: Special Focus on the Nitric Oxide system and Metabolism of Inositol Hexakisphosphate. University of Aarhus.

Jayatissa, M. N. (2007). Pathophysiology of depression and mechanisms of antidepressant treatments; focus on neurogenesis and gene expression in a chronic mild stress animal model of depression. Centre for Psychiatric Research: Faculty of Health Sciences. University of Aarhus.

Bouzinova, E. (2007). Sodium dependent acid/base transport in regulation of intracellular pH in rat choroid plexus. Fællestrykkeriet SUN Aarhus Universitet.

2006

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Müller, H. K. (2006). Identification and Characterisation of Serotonin Transporter Interacting Proteins. Dublin, Ireland.

Jacobsen, I. S. (2006). Identification of susceptibility genes for psychiatric diseases based on structural chromosome aberrations. Faculty of Health Sciences. University of Aarhus.

Neubauer, H. A. (2006). Mapping and characterization of an allosteric mechanism on the serotonin transporter. Det sundhedsvidenskabelige Fakultet, Aarhus Universitet.

2001-2005

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Sinning, S. (2005). Characterisation of the ligand binding site of the human serotonin transporter. Aarhus Universitet.

Jensen, B. R. (2002). Cognitive Function in Major Depression and Normal Subjects: The Danish PET/depression Project. Århus.

Dorph-Petersen, K-A. (2001). Neuronal changes in the dorsal raphe nucleus in depression? University of Aarhus.

PhD dissertations - list

Vibholm, A. K., Landau, A., Alstrup, A. K. O., Jacobsen, J., Hansen, K. V., Munk, O. L. ... Brooks, D. J. (Accepted/In press). Activation of NMDA receptor ion channels by deep brain stimulation in the pig visualised with [18F]GE-179 PET. Brain Stimulation.

Happ, D. F., Wegener, G. & Tasker, R. A. (2020). Effect of ischemic lesions in medial prefrontal cortex and nucleus accumbens on affective behavior in rats. Behavioural Brain Research, 378, [112234]. https://doi.org/10.1016/j.bbr.2019.112234

Hume, A. W. & Tasker, R. A. (2020). Endothelin-1-Induced Ischemic Damage and Functional Impairment Is Mediated Primarily by NR2B-Containing NMDA Receptors. Neurotoxicity Research, 37(2), 349-355. https://doi.org/10.1007/s12640-019-00138-3

Chen, F., Bertelsen, A. B., Holm, I. E., Nyengaard, J. R., Rosenberg, R. & Dorph-Petersen, K. A. (2020). Hippocampal volume and cell number in depression, schizophrenia, and suicide subjects. Brain Research, 1727, [146546]. https://doi.org/10.1016/j.brainres.2019.146546

Leonard, B. E. & Wegener, G. (2020). Inflammation, insulin resistance and neuroprogression in depression. Acta Neuropsychiatrica, 32(1), 1-9. https://doi.org/10.1017/neu.2019.17

Silote, G. P., de Oliveira, S. F. S., Ribeiro, D. E., Machado, M. S., Andreatini, R., Joca, S. R. L. & Beijamini, V. (2020). Ketamine effects on anxiety and fear-related behaviors: Current literature evidence and new findings. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 100, [109878]. https://doi.org/10.1016/j.pnpbp.2020.109878

Varastehmoradi, B., Wegener, G., Sanchez, C. & Smith, K. L. (2020). Opioid system modulation of cognitive affective bias implications for the treatment of mood disorders. Behavioural Pharmacology, 31(2&3), 122-135. https://doi.org/10.1097/FBP.0000000000000559

Landau, A. M., Noer, O., Alstrup, A. K. O., Audrain, H., Wegener, G., Gjedde, A. ... Winterdahl, M. (2020). Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain. Molecular Imaging and Biology. https://doi.org/10.1007/s11307-020-01476-x

Ribeiro, D. E., Casarotto, P. C., Spiacci, A. J., Fernandes, G. G., Pinheiro, L. C., Tanus-Santos, J. E. ... Biojone, C. (2019). Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 93(July), 232-239. https://doi.org/10.1016/j.pnpbp.2019.04.007

Musazzi, L., Sala, N., Tornese, P., Gallivanone, F., Belloli, S., Conte, A. ... Popoli, M. (2019). Acute Inescapable Stress Rapidly Increases Synaptic Energy Metabolism in Prefrontal Cortex and Alters Working Memory Performance. Cerebral Cortex, 29(12), 4948–4957. https://doi.org/10.1093/cercor/bhz034

Bannach-Brown, A., Tillmann, S., MacLeod, M. R. & Wegener, G. (2019). Administration of galacto-oligosaccharide prebiotics in the Flinders Sensitive Line animal model of depression. BMJ Open Science, 3(1), e000017. https://doi.org/10.1136/bmjos-2018-000017

Metaxas, A., Thygesen, C., Kempf, S. J., Anzalone, M., Vaitheeswaran, R., Petersen, S. ... Finsen, B. (2019). Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease. Scientific Reports, 9, [15758]. https://doi.org/10.1038/s41598-019-52357-5

Tillmann, S., Abildgaard, A., Winther, G. & Wegener, G. (2019). Altered fecal microbiota composition in the Flinders Sensitive Line rat model of depression. Psychopharmacology, 236(5), 1445-1457. https://doi.org/10.1007/s00213-018-5094-2

Ribeiro, D. E., Müller, H. K., Elfving, B., Eskelund, A., Joca, S. & Wegener, G. (2019). Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation. Journal of Psychopharmacology, 33(11), 1436-1446. https://doi.org/10.1177/0269881119872173

Barbu, M. C., Zeng, Y., Shen, X., Cox, S. R., Clarke, T-K., Gibson, J. ... Whalley, H. C. (2019). Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank. Biological psychiatry. Cognitive neuroscience and neuroimaging, 4(1), 91-100. https://doi.org/10.1016/j.bpsc.2018.07.006

Sartim, A. G., Brito, B. M., Gobira, P. H. & Joca, S. R. L. (2019). Attenuation of glutamatergic and nitrergic system contributes to the antidepressant-like effect induced by capsazepine in the forced swimming test. Behavioural Pharmacology, 59-66. [30(1)]. https://doi.org/10.1097/FBP.0000000000000416

Martis, L. S., Wiborg, O., Holmes, M. C. & Harris, A. P. (2019). BDNF ^+/− rats exhibit depressive phenotype and altered expression of genes relevant in mood disorders. Genes, Brain and Behavior, 18(2), [e12546]. https://doi.org/10.1111/gbb.12546

Tillmann, S., Happ, D. F., Mikkelsen, P. F., Geisel, J., Wegener, G. & Obeid, R. (2019). Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression. Behavioural Brain Research, 364, 274-280. https://doi.org/10.1016/j.bbr.2019.02.011

Kaadt, E., Mumm, B. H., Andersen, S. N., Damgaard, C. K. & Elfving, B. (2019). Biomarkers of depression - Focusing on non-coding RNA. 1:1-32.

Paternoster, V., Svanborg, M., Edhager, A. V., Rajkumar, A. P., Eickhardt, E. A., Pallesen, J. ... Christensen, J. H. (2019). Brain proteome changes in female Brd1+/- mice unmask dendritic spine pathology and show enrichment for schizophrenia risk. Neurobiology of Disease, 124, 479-488. https://doi.org/10.1016/j.nbd.2018.12.011

Sales, A. J., Fogaça, M. V., Sartim, A. G., Pereira, V. S., Wegener, G., Guimarães, F. S. & Joca, S. R. L. (2019). Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. Molecular Neurobiology, 56(2), 1070–1081. https://doi.org/10.1007/s12035-018-1143-4

Anzabi, M., Angleys, H., Aamand, R., Ardalan, M., Mouridsen, K., Rasmussen, P. M. ... Iversen, N. K. (2019). Capillary flow disturbances after experimental subarachnoid hemorrhage: a contributor to delayed cerebral ischemia? Microcirculation, 26(3), [e12516]. https://doi.org/10.1111/micc.12516

Tornese, P., Sala, N., Bonini, D., Bonifacino, T., La Via, L., Milanese, M. ... Musazzi, L. (2019). Chronic mild stress induces anhedonic behavior and changes in glutamate release, BDNF trafficking and dendrite morphology only in stress vulnerable rats. The rapid restorative action of ketamine. Neurobiology of Stress, 10, [100160]. https://doi.org/10.1016/j.ynstr.2019.100160

Hvilsom, A. S. T., Lillethorup, T. P., Iversen, P., Doudet, D. J., Wegener, G. & Landau, A. M. (2019). Cortical and striatal serotonin transporter binding in a genetic rat model of depression and in response to electroconvulsive stimuli. European Neuropsychopharmacology, 29(4), 493-500. https://doi.org/10.1016/j.euroneuro.2019.02.009

Herzog, D., Wegener, G., Lieb, K., Müller, M. & Treccani, G. (2019). Decoding the Mechanism of Action of Rapid-Acting Antidepressant Treatment Strategies: Does Gender Matter? International Journal of Molecular Sciences (Online), 20(4), [949]. https://doi.org/10.3390/ijms20040949

Elfving, B., Müller, H. K., Oliveras, I., Østerbøg, T. B., Rio-Alamos, C., Sanchez-Gonzalez, A. ... Aznar, S. (2019). Differential expression of synaptic markers regulated during neurodevelopment in a rat model of schizophrenia-like behavior. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 95, [109669]. https://doi.org/10.1016/j.pnpbp.2019.109669

Diniz, C., Biojone, C., Joca, S., Rantamaki, T., Castren, E., Guimaraes, F. & Casarotto, P. (2019). Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors. PeerJ, 7, [e6493]. https://doi.org/10.7717/peerj.6493

Pakkenberg, B., Olesen, M. V., Kaalund, S. S. & Dorph-Petersen, K-A. (2019). Editorial: Neurostereology. Frontiers in Neuroanatomy, 13, [42]. https://doi.org/10.3389/fnana.2019.00042

Köhler-Forsberg, O., Larsen, E. R., Buttenschøn, H. N., Rietschel, M., Hauser, J., Souery, D. ... Mors, O. (2019). Effect of antidepressant switching between nortriptyline and escitalopram after a failed first antidepressant treatment among patients with major depressive disorder. British Journal of Psychiatry, 215(2), 494-501. https://doi.org/10.1192/bjp.2018.302

Argyrousi, EK., Lagatta, DC., Schulutter, A., Weidner, MT., Zoller, J., van Goethem, NP. ... Prickaerts, J. (2019). Effects of DNA methyltransferase inhibition on pattern separation performance in mice. Neurobiology of Learning and Memory, 159, 6-15. https://doi.org/10.1016/j.nlm.2019.02.003

Landau, A., Alstrup, A. K. O., Noer, O., Winterdahl, M., Audrain, H., Møller, A. ... Doudet, D. J. (2019). Electroconvulsive stimulation differentially affects [¹¹C]MDL100,907 binding to cortical and subcortical 5HT_2A receptors in porcine brain. Journal of Psychopharmacology, 33(6), 714-721. [269881119836212]. https://doi.org/10.1177/0269881119836212

Silote, G. P., Sartim, A., Sales, A., Eskelund, A., Guimarães, F. S., Wegener, G. & Joca, S. (2019). Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms. Journal of Chemical Neuroanatomy, 98, 104-116. https://doi.org/10.1016/j.jchemneu.2019.04.006

Pereira, V. S., Joca, S. R. L., Harvey, B. H., Elfving, B. & Wegener, G. (2019). Esketamine and Rapastinel, but not Imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression. Acta Neuropsychiatrica, 31(5), 258-265. https://doi.org/10.1017/neu.2019.25

Treccani, G. (2019). From Structure to Behavior: Circuit Specificity of Stress-Induced Synaptic Plasticity in the Basolateral Amygdala Projection Neurons. Biological Psychiatry, 85(3), e7–e9.

Normann, C. & Buttenschøn, H. N. (2019). Gene-environment interactions between HPA-axis genes and stressful life events in depression: A systematic review. Acta Neuropsychiatrica, 31(4), 186-192. https://doi.org/10.1017/neu.2019.16

Zhang, X., Abdellaoui, A., Rucker, J., de Jong, S., Potash, J. B., Weissman, M. M. ... Levinson, D. F. (2019). Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts. Biological Psychiatry, 85(12), 1065-1073. https://doi.org/10.1016/j.biopsych.2019.02.022

Howard, D. M., Adams, M. J., Clarke, T-K., Hafferty, J. D., Gibson, J., Shirali, M. ... 23andMe Research Team (2019). Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nature Neuroscience, 22(3), 343-352. https://doi.org/10.1038/s41593-018-0326-7

Winther, G., Eskelund, A., Richter, C. B., Elfving, B., Müller, H. K., Lund, S. & Wegener, G. (2019). Grandmaternal High-fat Diet Primed Anxiety-like Behaviour in the Second-Generation Female Offspring. Behavioural Brain Research, 359, 47-55. https://doi.org/10.1016/j.bbr.2018.10.017

Kirkedal, C., Elfving, B., Müller, H. K., Moreira, F. A., Bindila, L., Lutz, B. ... Liebenberg, N. (2019). Hemisphere-dependent endocannabinoid system activity in prefrontal cortex and hippocampus of the Flinders Sensitive Line rodent model of depression. Neurochemistry International, 125(May), 7-15. https://doi.org/10.1016/j.neuint.2019.01.023

Metaxas, A., Thygesen, C., Briting, S. R. R., Landau, A., Darvesh, S. & Finsen, B. (2019). Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer’s Disease Patients. Frontiers in Cellular Neuroscience, 13, [538]. https://doi.org/10.3389/fncel.2019.00538

Rydbirk, R., Elfving, B., Folke, J., Pakkenberg, B., Winge, K., Brudek, T. & Aznar, S. (2019). Increased prefrontal cortex interleukin-2 protein levels and shift in the peripheral T cell population in progressive supranuclear palsy patients. Scientific Reports, 9(1), [7781]. https://doi.org/10.1038/s41598-019-44234-y

Czamara, D., Eraslan, G., Page, C. M., Lahti, J., Lahti-Pulkkinen, M., Hämäläinen, E. ... Binder, E. B. (2019). Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nature Communications, 10, [2548]. https://doi.org/10.1038/s41467-019-10461-0

Speed, M. S., Jefsen, O. H., Børglum, A. D., Speed, D. & Østergaard, S. D. (2019). Investigating the association between body fat and depression via Mendelian randomization. Translational Psychiatry, 9, [184]. https://doi.org/10.1038/s41398-019-0516-4

Speed, D., Hemani, G., Speed, M. S., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & Børglum, A. D. (2019). Investigating the causal relationship between neuroticism and depression via Mendelian Randomization. Acta Psychiatrica Scandinavica, 139(4), 395-397. https://doi.org/10.1111/acps.13009

Kohtala, S., Theilmann, W., Rosenholm, M., Müller, H. K., Kiuru, P., Wegener, G. ... Rantamäki, T. (2019). Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites. Neuropharmacology, 157, 107684. [107684]. https://doi.org/10.1016/j.neuropharm.2019.107684

Bay-Richter, C., Petersen, E., Liebenberg, N., Elfving, B. & Wegener, G. (2019). Latent toxoplasmosis aggravates anxiety- and depressive-like behaviour and suggest a role of gene-environment interactions in the behavioural response to the parasite. Behavioural Brain Research, 364(May), 133-139. https://doi.org/10.1016/j.bbr.2019.02.018

Bay-Richter, C., Buttenschøn, H. N., Mors, O., Eskelund, A., Budac, D., Kærlev, L. & Wegener, G. (2019). Latent toxoplasmosis and psychiatric symptoms - A role of tryptophan metabolism? Journal of Psychiatric Research, 110, 45-50. https://doi.org/10.1016/j.jpsychires.2018.12.016

Bannach-Brown, A., Przybyła, P., Thomas, J., Rice, A. S. C., Ananiadou, S., Liao, J. & Macleod, M. R. (2019). Machine learning algorithms for systematic review: Reducing workload in a preclinical review of animal studies and reducing human screening error. Systematic Reviews, 8(1), [23]. https://doi.org/10.1186/s13643-019-0942-7

Khan, A. R., Hansen, B., Danladi, J., Chuhutin, A., Wiborg, O., Nyengaard, J. R. & Jespersen, S. (2019). Neurite atrophy in dorsal hippocampus of rat indicates incomplete recovery of chronic mild stress induced depression: Neurite atrophy in the hippocampus show partial recovery of depression. NMR in Biomedicine, 32(3). https://doi.org/doi.org/10.1002/nbm.4057

Metaxas, A., Anzalone, M., Vaitheeswaran, R., Petersen, S., Landau, A. M. & Finsen, B. (2019). Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease. Alzheimer's Research & Therapy, 11(1), [38]. https://doi.org/10.1186/s13195-019-0491-2

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Karen Jul Madsen

Revised 27.09.2019