Publications 2017

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Tillmann, S., Pereira, V. S., Liebenberg, N., Christensen, A. K. & Wegener, G. (2017). ZL006, a small molecule inhibitor of PSD-95/nNOS interaction, does not induce antidepressant-like effects in two genetically predisposed rat models of depression and control animals. PLoS One, 12(8), 1-17. Article e0182698. https://doi.org/10.1371/journal.pone.0182698

Topiol, S., Bang-Andersen, B., Sanchez, C., Plenge, P., Loland, C. J., Juhl, K., Larsen, K., Bregnedal, P. & Bogeso, K. P. (2017). X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT. Bioorganic & Medicinal Chemistry Letters, 27(3), 470-478. https://doi.org/10.1016/j.bmcl.2016.12.037

Baandrup, L., Rasmussen, J. O., Klokker, L., Austin, S., Bjornshave, T., Bliksted, V. F., Fink-Jensen, A., Fohlmann, A. H., Hansen, J. P., Nielsen, M. K., Sandsten, K. E., Schultz, V., Voss-Knude, S. & Nordentoft, M. (2017). Treatment of adult patients with schizophrenia and complex mental health needs - A national clinical guideline (vol 70, pg 231, 2016). Nordic Journal of Psychiatry. Supplement, 71(2), 163-163. https://doi.org/10.1080/08039488.2017.1274149

Bomann, A. C., Jørgensen, M. B., Bo, S., Nielsen, M., Gede, L. B., Elfving, B. & Simonsen, E. (2017). The neurobiology of social deficits in female patients with borderline personality disorder: The importance of oxytocin. Personality and Mental Health, 11(2), 91–100. https://doi.org/10.1002/pmh.1369

Staunstrup, N. H., Starnawska, A., Nyegaard, M., Nielsen, A. L., Borglum, A. D. & Mors, O. (2017). The Genome-Wide DNA Methylation Profile of Peripheral Blood Is Not Systematically Changed by Short-Time Storage at Room Temperature. Epigenomes, 1(3), Article 23. https://doi.org/10.3390/epigenomes1030023

Nava, N., Treccani, G., Müller, H. K., Popoli, M., Wegener, G. & Elfving, B. (2017). The expression of plasticity-related genes in an acute model of stress is modulated by chronic desipramine in a time-dependent manner within medial prefrontal cortex. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 27(1), 19-28. https://doi.org/10.1016/j.euroneuro.2016.11.010

Aagaard, J., Foldager, L., Makki, A., Hansen, V. & Müller-Nielsen, K. (2017). The efficacy of psychoeducation on recurrent depression: A randomised trial with a two-year follow-up. Nordic Journal of Psychiatry, 71(3), 223-229. https://doi.org/10.1080/08039488.2016.1266385

Christiansen, S. L. (2017). The clockwork behind depression. Atlas of Science.

Kiderlen, M. & Dorph-Petersen, K. A. (2017). The Cavalieri estimator with unequal section spacing revisited. Image Analysis and Stereology, 36(2), 135-141. https://doi.org/10.5566/ias.1723

Winterdahl, M., Noer, O., Orlowski, D., Jakobsen, S., Alstrup, A. K. O., Scheel-Krüger, J., Kringelbach, M. L., Møller, A. & Landau, A. M. (2017). The “addicted” minipig brain: Sugar intake decreases dopamine D2/3 receptor availability in brain regions implicated in addiction. Poster session presented at 1st Annual Research Meeting, Aarhus, Denmark.

Nava, N., Treccani, G., Al-Absi, A.-R., Elfving, B., Müller, H. K., Popoli, M., Wegener, G. & Nyengaard, J. R. (2017). Temporal Dynamics of Acute Stress-Induced Dendritic Remodeling in Medial Prefrontal Cortex and the Protective Effect of Desipramine. Cerebral Cortex, 27(1), 694-705. https://doi.org/10.1093/cercor/bhv254

Ekemohn, M., Nielsen, M. K., Grahm, M., Tingström, A., Kousholt, B. S., Wegener, G. & Bay-Richter, C. (2017). Systematic evaluation of skeletal fractures caused by induction of electroconvulsive seizures in rat state a need for attention and refinement of the procedure. Acta Neuropsychiatrica, 29(6), 363-373. https://doi.org/10.1017/neu.2017.7

Bertelsen, F., Folloni, D., Møller, A., Landau, A. M., Scheel-Krüger, J. & Winterdahl, M. (2017). Suppressed play behaviour and decreased oxytocin receptor binding in the amygdala after prenatal exposure to low-dose valproic acid. Behavioural Pharmacology, 28(6), 450-457. https://doi.org/10.1097/FBP.0000000000000316

Christiansen, S. L. (2017). Stress-resilient Rats and the Circadian System in the Chronic Mild Stress Model of Depression. Abstract from SCNP 2017, København, Denmark.

Christiansen, S. L. (2017). Stress-resilient Rats and the Circadian System in the Chronic Mild Stress Model of Depression. Abstract from Neuroscience Day - Let's rethink memory 2017, Aarhus, Denmark.

Mothes, L., Kristensen, C. H., Oliveira, R. G., Argimon, I. I. D. L., Fonseca, R. P. & Irigaray, T. Q. (2017). Stressful events and executive functioning in adolescents with and without history of grade repetition. Universitas Psychologica, 16(4), 1-12. https://doi.org/10.11144/Javeriana.upsy16-4.seef

Ardalan, M., Wegener, G., H Rafati, A. & R Nyengaard, J. (2017). S-Ketamine Rapidly Reverses Synaptic and Vascular Deficits of Hippocampus in Genetic Animal Model of Depression. International Journal of Neuropsychopharmacology, 20(3), 247-256. https://doi.org/10.1093/ijnp/pyw098

Haase, J., Grudzinska-Goebel, J., Müller, H. K., Münster-Wandowski, A., Chow, E., Wynne, K., Farsi, Z., Zander, J.-F. & Ahnert-Hilger, G. (2017). Serotonin Transporter Associated Protein Complexes Are Enriched in Synaptic Vesicle Proteins and Proteins Involved in Energy Metabolism and Ion Homeostasis. ACS Chemical Neuroscience, 8(5), 1101-1116. https://doi.org/10.1021/acschemneuro.6b00437

Bahor, Z., Liao, J., Macleod, M., Bannach-Brown, A., McCann, S. K., Wever, K. E., Thomas, J., Ottavi, T., Howells, D. W., Rice, A., Ananiadou, S. & Sena, E. (2017). Risk of bias reporting in the recent animal focalcerebral ischaemia literature. Clinical Science, 131(20), 2525-2532. https://doi.org/10.1042/CS20160722

Ardalan, M., Rafati, A. H., Nyengaard, J. R. & Wegener, G. (2017). Rapid Antidepressant Effect of Ketamine Correlates with Astroglial Plasticity in the Hippocampus. British Journal of Pharmacology, 174(6), 483-492. https://doi.org/10.1111/bph.13714

Phan, J.-A., Landau, A. M., Jakobsen, S. & Gjedde, A. (2017). Radioligand binding analysis of α 2 adrenoceptors with [11C]yohimbine in brain in vivo: Extended Inhibition Plot correction for plasma protein binding. Scientific Reports, 7(7), Article 15979. https://doi.org/10.1038/s41598-017-16020-1

Bernard, P. B., Ramsay, L. A., MacDonald, D. S. & Tasker, R. A. (2017). Progressive changes in hippocampal cytoarchitecture in a neurodevelopmental rat model of epilepsy: implications for understanding presymptomatic epileptogenesis, predictive diagnosis, and targeted treatments. The EPMA journal, 8(3), 247-254. https://doi.org/10.1007/s13167-017-0111-9

Buttenschøn, H. N., Nielsen, M. N., Thotakura, G., Lee, C. W., Nykjær, A., Mors, O. & Glerup, S. (2017). Progranulin gene variation affects serum progranulin levels differently in Danish bipolar individuals compared with healthy controls. Psychiatric Genetics, 27(3), 89-95. https://doi.org/10.1097/YPG.0000000000000168

Abildgaard, A., Elfving, B., Hokland, M., Wegener, G. & Lund, S. (2017). Probiotic treatment reduces depressive-like behaviour in rats independently of diet. Psychoneuroendocrinology, 79, 40-48. https://doi.org/10.1016/j.psyneuen.2017.02.014

Abildgaard, A., Elfving, B., Hokland, M., Lund, S. & Wegener, G. (2017). Probiotic treatment protects against the pro-depressant-like effect of high-fat diet in Flinders Sensitive Line rats. Brain, Behavior, and Immunity, 65, 33-42. https://doi.org/10.1016/j.bbi.2017.04.017

Dorph-Petersen, K.-A. & Lewis, D. A. (2017). Postmortem structural studies of the thalamus in schizophrenia. Schizophrenia Research, 180, 28-35. https://doi.org/10.1016/j.schres.2016.08.007

Campos, A. C., Fogaça, M. V., Scarante, F. F., Joca, S. R. L., Sales, A. J., Gomes, F. V., Sonego, A. B., Rodrigues, N. S., Galve-Roperh, I. & Guimarães, F. S. (2017). Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders. Frontiers in Pharmacology, 8(MAY), 269. Article 269. https://doi.org/10.3389/fphar.2017.00269

García-González, J., Tansey, K. E., Hauser, J., Henigsberg, N., Maier, W., Mors, O., Placentino, A., Rietschel, M., Souery, D., Žagar, T., Czerski, P. M., Jerman, B., Buttenschøn, H. N., Schulze, T. G., Zobel, A., Farmer, A., Aitchison, K. J., Craig, I., McGuffin, P. ... Major Depressive Disorder Working Group of the Psychiatric Genomic Consortium (2017). Pharmacogenetics of antidepressant response: A polygenic approach. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 75, 128-134. https://doi.org/10.1016/j.pnpbp.2017.01.011

Sales, A. J., Hiroaki-Sato, V. A. & Joca, S. R. L. (2017). Participation of hippocampal nitric oxide synthase and soluble guanylate cyclase in the modulation of behavioral responses elicited by the rat forced swimming test. Behavioural Pharmacology, 28(1), 19-29. https://doi.org/10.1097/FBP.0000000000000263

Waller, J. A., Nygaard, S. H., Li, Y., du Jardin, K. G., Tamm, J. A., Abdourahman, A., Elfving, B., Pehrson, A. L., Sánchez, C. & Wernersson, R. (2017). Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents. BMC Neuroscience, 18(1), 56. Article 56. https://doi.org/10.1186/s12868-017-0376-x

Olesen, L. O., Sivasaravanaparan, M., Severino, M., Babcock, A. A., Bouzinova, E. V., West, M. J., Wiborg, O. & Finsen, B. (2017). Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APP(swe)/PS1(dE9) transgenic mice: Effect of long-term treatment with paroxetine. Neurobiology of Disease, 104, 50-60. https://doi.org/10.1016/j.nbd.2017.04.021

Febbraro, F., Svenningsen, K., Thao Phuong Tran & Wiborg, O. (2017). Neuronal substrates underlying stress resilience and susceptibility in rats. PLoS One, 12(6), Article 0179434. https://doi.org/10.1371/journal.pone.0179434

Hangaard, L., Bouzinova, E., Stæhr, C. A., Dam, V. S., Kim, S., Xie, Z., Aalkjær, C. & Matchkov, V. (2017). Na,K-ATPase regulates intercellular communication in the vascular wall via cSrc kinase dependent connexin43 phosphorylation. American Journal of Physiology: Cell Physiology, 4(312), C385-C397. https://doi.org/10.1152/ajpcell.00347.2016

Lillethorup, T. P., GLUD, AN., Jakobsen, S., Alstrup, A. K. O., Moeller, A., Sørensen, J. C. H., Doudet, D. J. & Landau, A. M. (2017). Multi-Neurotransmitter Deficits in a Minipig Model of Parkinson’s Disease. Poster session presented at 1st Annual Research Meeting, Aarhus, Denmark.

Tillmann, S. (2017). Mind the gap – towards complete and transparent reporting of animal research. Medical Writing, 26(4), 24-27. http://journal.emwa.org/preclinical-studies/mind-the-gap-towards-complete-and-transparent-reporting-of-animal-research/

Qvist, P., Rajkumar, A. P., Redrobe, J. P., Nyegaard, M., Christensen, J. H., Mors, O., Wegener, G., Didriksen, M. & Børglum, A. D. (2017). Mice heterozygous for an inactivated allele of the schizophrenia associated Brd1 gene display selective cognitive deficits with translational relevance to schizophrenia. Neurobiology of Learning and Memory, 141, 44-52. https://doi.org/10.1016/j.nlm.2017.03.009

Silva Pereira, V., Elfving, B., Joca, S. R. L. & Wegener, G. (2017). Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats. European Journal of Pharmacology, 815, 304-311. https://doi.org/10.1016/j.ejphar.2017.09.029

Sinning, S. & Lund, A. E. (2017). Jungle Brew and Depression:Molecular Pharmacology of Ayahuasca Alkaloids on Monoamine Transporter Systems. Poster session presented at 9th Annual Meeting of the Danish Society of Pharmacology, Odense, Denmark.

Antila, H., Ryazantseva, M., Popova, D., Sipilä, P., Guirado, R., Kohtala, S., Yalcin, I., Lindholm, J., Vesa, L., Sato, V., Cordeira, J., Autio, H., Kislin, M., Rios, M., Joca, S., Casarotto, P., Khiroug, L., Lauri, S., Taira, T. ... Rantamäki, T. (2017). Isoflurane produces antidepressant effects and induces TrkB signaling in rodents. Scientific Reports, 7(1), 7811. Article 7811. https://doi.org/10.1038/s41598-017-08166-9

Chakroborty, S., Geisbush, T. R., Dale, E., Pehrson, A. L., Sanchez, C. & West, A. R. (2017). Impact of Vortioxetine on Synaptic Integration in Prefrontal-Subcortical Circuits: Comparisons with Escitalopram. Frontiers in Pharmacology, 8(OCT), Article 764. https://doi.org/10.3389/fphar.2017.00764

CORtisolNETwork (CORNET) Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC) & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC) (2017). Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes. Scientific Reports, 7(1), Article 15351. https://doi.org/10.1038/s41598-017-11852-3

Power, R. A., Tansey, K. E., Buttenschøn, H. N., Cohen-Woods, S., Bigdeli, T., Hall, L. S., Kutalik, Z., Lee, S. H., Ripke, S., Steinberg, S., Teumer, A., Viktorin, A., Wray, N. R., Arolt, V., Baune, B. T., Boomsma, D. I., Børglum, A. D., Castelao, E., Craddock, N. ... CONVERGE Consortium, CARDIoGRAM Consortium, GERAD1 Consortium (2017). Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Biological Psychiatry, 81(4), 325–335. https://doi.org/10.1016/j.biopsych.2016.05.010

Bigdeli, T. B., Ripke, S., Peterson, R. E., Trzaskowski, M., Bacanu, S.-A., Abdellaoui, A., Andlauer, T. F. M., Beekman, A. T. F., Berger, K., Blackwood, D. H. R., Boomsma, D. I., Breen, G., Buttenschøn, H. N., Byrne, E. M., Cichon, S., Clarke, T.-K., Couvy-Duchesne, B., Craddock, N., de Geus, E. J. C. ... Kendler, K. S. (2017). Genetic effects influencing risk for major depressive disorder in China and Europe. Translational Psychiatry, 7(3), e1074. Article e1074. https://doi.org/10.1038/tp.2016.292

du Jardin, K. G., Müller, H. K., Sanchez, C., Wegener, G. & Elfving, B. (2017). Gene expression related to serotonergic and glutamatergic neurotransmission is altered in the Flinders Sensitive Line rat model of depression: Effect of ketamine. Synapse, 71(1), 37–45. https://doi.org/10.1002/syn.21940

Ventorp, F., Bay-Richter, C., Nagendra, A., Janelidze, S., Matsson, V., Lipton, J., Nordström, U., Westrin, Å., Brundin, P. & Brundin, L. (2017). Exendin-4 Treatment Improves LPS-Induced Depressive-Like Behavior Without Affecting Pro-Inflammatory Cytokines. Journal of Parkinson's Disease, 7(2), 263-273. https://doi.org/10.3233/JPD-171068

Csabai, D., Seress, L., Varga, Z., Abraham, H., Miseta, A., Wiborg, O. & Czeh, B. (2017). Electron Microscopic Analysis of Hippocampal Axo-Somatic Synapses in a Chronic Stress Model for Depression. The Hippocampus, 27(1), 17-27. https://doi.org/10.1002/hipo.22650

Déziel, R. A. & Tasker, R. A. (2017). Effects of endothelin-induced prefrontal cortical lesions on delay discounting in the rat. Behavioral Neuroscience, 131(1), 11-19. https://doi.org/10.1037/bne0000179

Phan, J.-A., Stokholm, K., Zareba-Paslawska, J., Jakobsen, S., Vang, K., Gjedde, A., Landau, A. M. & Romero-Ramos, M. (2017). Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson's disease. Scientific Reports, 7(1), Article 6363. https://doi.org/10.1038/s41598-017-06724-9

Eskelund, A., Li, Y., Budac, D. P., Müller, H. K., Gulinello, M., Sanchez, C. & Wegener, G. (2017). Drugs with antidepressant properties affect tryptophan metabolites differently in rodent models with depression-like behavior. Journal of Neurochemistry, 142(1), 118-131. https://doi.org/10.1111/jnc.14043

Stein, D. J. & Wegener, G. (2017). Discovery versus implementation research on mental disorders in low- and middle-income countries. Acta Neuropsychiatrica, 29(4), 191-192. https://doi.org/10.1017/neu.2017.25

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Revised 31.01.2023

Karen Jul Madsen