Publications 2019

2019

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Zhang, X., Abdellaoui, A., Rucker, J., de Jong, S., Potash, J. B., Weissman, M. M., Shi, J., Knowles, J. A., Pato, C., Pato, M., Sobell, J., Smit, J. H., Hottenga, J. J., de Geus, E. J. C., Lewis, C. M., Buttenschøn, H. N., Craddock, N., Jones, I., Jones, L. ... Levinson, D. F. (2019). Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts. Biological Psychiatry, 85(12), 1065-1073. https://doi.org/10.1016/j.biopsych.2019.02.022

Witt, N. A., Lee, B., Ghent, K., Zhang, W. Q., Pehrson, A. L., Sánchez, C. & Gould, G. G. (2019). Vortioxetine Reduces Marble Burying but Only Transiently Enhances Social Interaction Preference in Adult Male BTBR T⁺Itpr3^tf/J Mice. ACS Chemical Neuroscience, 10(10), 4319-4327. https://doi.org/10.1021/acschemneuro.9b00386

Winther, G., Eskelund, A., Richter, C. B., Elfving, B., Müller, H. K., Lund, S. & Wegener, G. (2019). Grandmaternal High-fat Diet Primed Anxiety-like Behaviour in the Second-Generation Female Offspring. Behavioural Brain Research, 359, 47-55. https://doi.org/10.1016/j.bbr.2018.10.017

Winterdahl, M., Noer, O., Orlowski, D., Schacht, A. C., Jakobsen, S., Alstrup, A. K. O., Gjedde, A. & Landau, A. (2019). Sucrose intake lowers μ-opioid and dopamine D2/3 receptor availability in porcine brain. Scientific Reports, 9(1), Article 16918. https://doi.org/10.1038/s41598-019-53430-9

Treccani, G. (2019). From Structure to Behavior: Circuit Specificity of Stress-Induced Synaptic Plasticity in the Basolateral Amygdala Projection Neurons. Biological Psychiatry, 85(3), E7-E9. https://doi.org/10.1016/j.biopsych.2018.11.017

Treccani, G., Ardalan, M., Chen, F., Musazzi, L., Popoli, M., Wegener, G., Nyengaard, J. R. & Müller, H. K. (2019). S-Ketamine Reverses Hippocampal Dendritic Spine Deficits in Flinders Sensitive Line Rats Within 1 h of Administration. Molecular Neurobiology, 56(11), 7368-7379. https://doi.org/10.1007/s12035-019-1613-3

Tornese, P., Sala, N., Bonini, D., Bonifacino, T., La Via, L., Milanese, M., Treccani, G., Seguini, M., Ieraci, A., Mingardi, J., Nyengaard, J. R., Calza, S., Bonanno, G., Wegener, G., Barbon, A., Popoli, M. & Musazzi, L. (2019). Chronic mild stress induces anhedonic behavior and changes in glutamate release, BDNF trafficking and dendrite morphology only in stress vulnerable rats. The rapid restorative action of ketamine. Neurobiology of Stress, 10, Article 100160. https://doi.org/10.1016/j.ynstr.2019.100160

Tillmann, S. & Wegener, G. (2019). Probiotics reduce risk-taking behavior in the Elevated Plus Maze in the Flinders Sensitive Line rat model of depression. Behavioural Brain Research, 359, 755-762. https://doi.org/10.1016/j.bbr.2018.08.025

Tillmann, S., Abildgaard, A., Winther, G. & Wegener, G. (2019). Altered fecal microbiota composition in the Flinders Sensitive Line rat model of depression. Psychopharmacology, 236(5), 1445-1457. https://doi.org/10.1007/s00213-018-5094-2

Tillmann, S., Happ, D. F., Mikkelsen, P. F., Geisel, J., Wegener, G. & Obeid, R. (2019). Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression. Behavioural Brain Research, 364, 274-280. https://doi.org/10.1016/j.bbr.2019.02.011

Tillmann, S., Skibdal, H. E., Christiansen, S. H., Gøtzsche, C. R., Hassan, M., Mathé, A. A., Wegener, G. & Woldbye, D. P. D. (2019). Sustained overexpression of neuropeptide S in the amygdala reduces anxiety-like behavior in rats. Behavioural Brain Research, 367, 28-34. https://doi.org/10.1016/j.bbr.2019.03.039

Speed, D., Hemani, G., Speed, M. S., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & Børglum, A. D. (2019). Investigating the causal relationship between neuroticism and depression via Mendelian Randomization. Acta Psychiatrica Scandinavica, 139(4), 395-397. https://doi.org/10.1111/acps.13009

Speed, M. S., Jefsen, O. H., Børglum, A. D., Speed, D. & Østergaard, S. D. (2019). Investigating the association between body fat and depression via Mendelian randomization. Translational Psychiatry, 9(1), Article 184. https://doi.org/10.1038/s41398-019-0516-4

Smith, K. L., Cunningham, J. I., Eyerman, D. J., Dean, R. L., Deaver, D. R. & Sanchez, C. (2019). Opioid system modulators buprenorphine and samidorphan alter behavior and extracellular neurotransmitter concentrations in the Wistar Kyoto rat. Neuropharmacology, 146(March), 316-326. https://doi.org/10.1016/j.neuropharm.2018.11.015

Silote, G. P., Sartim, A., Sales, A., Eskelund, A., Guimarães, F. S., Wegener, G. & Joca, S. (2019). Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms. Journal of Chemical Neuroanatomy, 98, 104-116. https://doi.org/10.1016/j.jchemneu.2019.04.006

Sartim, A. G., Brito, B. M., Gobira, P. H. & Joca, S. R. L. (2019). Attenuation of glutamatergic and nitrergic system contributes to the antidepressant-like effect induced by capsazepine in the forced swimming test. Behavioural Pharmacology, 30(1), 59-66. Article 30(1). https://doi.org/10.1097/FBP.0000000000000416

Sales, A. J., Fogaça, M. V., Sartim, A. G., Pereira, V. S., Wegener, G., Guimarães, F. S. & Joca, S. R. L. (2019). Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. Molecular Neurobiology, 56(2), 1070–1081. https://doi.org/10.1007/s12035-018-1143-4

Rydbirk, R., Elfving, B., Folke, J., Pakkenberg, B., Winge, K., Brudek, T. & Aznar, S. (2019). Increased prefrontal cortex interleukin-2 protein levels and shift in the peripheral T cell population in progressive supranuclear palsy patients. Scientific Reports, 9(1), Article 7781. https://doi.org/10.1038/s41598-019-44234-y

Ribeiro, D. E., Casarotto, P. C., Spiacci, A. J., Fernandes, G. G., Pinheiro, L. C., Tanus-Santos, J. E., Zangrossi, H. J., Guimarães, F. S., Joca, S. R. L. & Biojone, C. (2019). Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 93(July), 232-239. https://doi.org/10.1016/j.pnpbp.2019.04.007

Ribeiro, D. E., Roncalho, A. L., Glaser, T., Ulrich, H., Wegener, G. & Joca, S. (2019). P2X7 Receptor Signaling in Stress and Depression. International Journal of Molecular Sciences , 20(11), Article 2778. https://doi.org/10.3390/ijms20112778

Ribeiro, D. E., Müller, H. K., Elfving, B., Eskelund, A., Joca, S. & Wegener, G. (2019). Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation. Journal of Psychopharmacology, 33(11), 1436-1446. https://doi.org/10.1177/0269881119872173

Ribeiro, D. E., Casarotto, P. C., Staquini, L., Pinto E Silva, M. A., Biojone, C., Wegener, G. & Joca, S. (2019). Reduced P2X receptor levels are associated with antidepressant effect in the learned helplessness model. PeerJ, 2019(10), Article e7834. https://doi.org/10.7717/peerj.7834

Pereira, V. S., Suavinha, A. C. D. R., Wegener, G. & Joca, S. R. L. (2019). Prelimbic neuronal nitric oxide synthase inhibition exerts antidepressant-like effects independently of BDNF signalling cascades. Acta Neuropsychiatrica, 31(3), 143-150. https://doi.org/10.1017/neu.2018.39

Pereira, V. S., Joca, S. R. L., Harvey, B. H., Elfving, B. & Wegener, G. (2019). Esketamine and Rapastinel, but not Imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression. Acta Neuropsychiatrica, 31(5), 258-265. https://doi.org/10.1017/neu.2019.25

Paternoster, V., Svanborg, M., Edhager, A. V., Rajkumar, A. P., Eickhardt, E. A., Pallesen, J., Grove, J., Qvist, P., Fryland, T., Wegener, G., Nyengaard, J. R., Mors, O., Palmfeldt, J., Børglum, A. D. & Christensen, J. H. (2019). Brain proteome changes in female Brd1+/- mice unmask dendritic spine pathology and show enrichment for schizophrenia risk. Neurobiology of Disease, 124, 479-488. https://doi.org/10.1016/j.nbd.2018.12.011

Pakkenberg, B., Olesen, M. V., Kaalund, S. S. & Dorph-Petersen, K.-A. (2019). Editorial: Neurostereology. Frontiers in Neuroanatomy, 13, Article 42. https://doi.org/10.3389/fnana.2019.00042

Pakkenberg, B., Olesen, M. V., Kaalund, S. S. & Dorph-Petersen, K.-A. (Eds.) (2019). Neurostereology. Frontiers Media. Frontiers Research Topics Frontiers in Neuroanatomy https://doi.org/10.3389/978-2-88945-880-6

Normann, C. & Buttenschøn, H. N. (2019). Gene-environment interactions between HPA-axis genes and stressful life events in depression: A systematic review. Acta Neuropsychiatrica, 31(4), 186-192. https://doi.org/10.1017/neu.2019.16

Musazzi, L., Sala, N., Tornese, P., Gallivanone, F., Belloli, S., Conte, A., Di Grigoli, G., Chen, F., Ikinci, A., Treccani, G., Bazzini, C., Castiglioni, I., Nyengaard, J. R., Wegener, G., Moresco, R. M. & Popoli, M. (2019). Acute Inescapable Stress Rapidly Increases Synaptic Energy Metabolism in Prefrontal Cortex and Alters Working Memory Performance. Cerebral Cortex, 29(12), 4948–4957. https://doi.org/10.1093/cercor/bhz034

Metaxas, A., Anzalone, M., Vaitheeswaran, R., Petersen, S., Landau, A. M. & Finsen, B. (2019). Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease. Alzheimer's Research & Therapy, 11(1), Article 38. https://doi.org/10.1186/s13195-019-0491-2

Metaxas, A., Thygesen, C., Kempf, S. J., Anzalone, M., Vaitheeswaran, R., Petersen, S., Landau, A. M., Audrain, H., Teeling, J. L., Darvesh, S., Brooks, D. J., Larsen, M. R. & Finsen, B. (2019). Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease. Scientific Reports, 9(1), Article 15758. https://doi.org/10.1038/s41598-019-52357-5

Metaxas, A., Thygesen, C., Briting, S. R. R., Landau, A., Darvesh, S. & Finsen, B. (2019). Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer’s Disease Patients. Frontiers in Cellular Neuroscience, 13, Article 538. https://doi.org/10.3389/fncel.2019.00538

Martis, L. S., Wiborg, O., Holmes, M. C. & Harris, A. P. (2019). BDNF ^+/− rats exhibit depressive phenotype and altered expression of genes relevant in mood disorders. Genes, Brain and Behavior, 18(2), Article e12546. https://doi.org/10.1111/gbb.12546

Mansouri, M., Pouretemad, H., Roghani, M., Wegener, G. & Ardalan, M. (2019). Environmental Enrichment Ameliorates Repetitive Behaviors in a Rat Model of Autism. Journal of Neurodevelopmental Cognition, 1, 108-117. http://jncog.sbu.ac.ir/issue/view/1326

Mansouri, M., Pouretemad, H., Roghani, M., Wegener, G. & Ardalan, M. (2019). Oxytocin improves autistic-like behaviors induced by maternal deprivation in female rats. DANESHVAR MEDICINE, 27(144 #T00275), 49-60. https://www.sid.ir/en/Journal/ViewPaper.aspx?ID=716476

Madsen, T., Buttenschøn, H. N., Uher, R., Behrendt-Møller, I., Perroud, N., Maier, W., Hauser, J., Dernovsek, M. Z., Henigsberg, N., Souery, D., Rietschel, M., McGuffin, P., Aitchison, K. J., Mors, O. & Köhler-Forsberg, O. (2019). Trajectories of Suicidal Ideation During 12 Weeks of Escitalopram or Nortriptyline Antidepressant Treatment Among 811 Patients With Major Depressive Disorder. The Journal of Clinical Psychiatry, 80(4), Article 18m12575. https://doi.org/10.4088/JCP.18m12575

Leonard, B. E. & Wegener, G. (2019). Inflammation, insulin resistance and neuroprogression in depression. Acta Neuropsychiatrica, 32(1), 1-9. https://doi.org/10.1017/neu.2019.17

Landau, A., Alstrup, A. K. O., Noer, O., Winterdahl, M., Audrain, H., Møller, A., Videbech, P., Wegener, G., Gjedde, A. & Doudet, D. J. (2019). Electroconvulsive stimulation differentially affects [¹¹C]MDL100,907 binding to cortical and subcortical 5HT_2A receptors in porcine brain. Journal of Psychopharmacology, 33(6), 714-721. Article 269881119836212. https://doi.org/10.1177/0269881119836212

Kohtala, S., Theilmann, W., Rosenholm, M., Müller, H. K., Kiuru, P., Wegener, G., Yli-Kauhaluoma, J. & Rantamäki, T. (2019). Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites. Neuropharmacology, 157, 107684. Article 107684. https://doi.org/10.1016/j.neuropharm.2019.107684

Köhler-Forsberg, O., Larsen, E. R., Buttenschøn, H. N., Rietschel, M., Hauser, J., Souery, D., Maier, W., Farmer, A., McGuffin, P., Aitchison, K. J., Uher, R. & Mors, O. (2019). Effect of antidepressant switching between nortriptyline and escitalopram after a failed first antidepressant treatment among patients with major depressive disorder. British Journal of Psychiatry, 215(2), 494-501. https://doi.org/10.1192/bjp.2018.302

Kirkedal, C., Elfving, B., Müller, H. K., Moreira, F. A., Bindila, L., Lutz, B., Wegener, G. & Liebenberg, N. (2019). Hemisphere-dependent endocannabinoid system activity in prefrontal cortex and hippocampus of the Flinders Sensitive Line rodent model of depression. Neurochemistry International, 125(May), 7-15. https://doi.org/10.1016/j.neuint.2019.01.023

Khan, A. R., Hansen, B., Danladi, J., Chuhutin, A., Wiborg, O., Nyengaard, J. R. & Jespersen, S. (2019). Neurite atrophy in dorsal hippocampus of rat indicates incomplete recovery of chronic mild stress induced depression: Neurite atrophy in the hippocampus show partial recovery of depression. NMR in Biomedicine, 32(3), Article e4057. https://doi.org/10.1002/nbm.4057

Kaadt, E., Mumm, B. H., Andersen, S. N., Damgaard, C. K. & Elfving, B. (2019). Biomarkers of depression - Focusing on non-coding RNA. 1:1-32.

Joca, S., Sartim, A., Roncalho, A., Diniz, C. & Wegener, G. (2019). Nitric oxide signalling and antidepressant action revisited. Cell and Tissue Research, 377(1), 45-58. https://doi.org/10.1007/s00441-018-02987-4

Jefsen, O., Højgaard, K., Christiansen, S. L., Elfving, B., Nutt, D. J., Wegener, G. & Müller, H. K. (2019). Psilocybin lacks antidepressant-like effect in the Flinders Sensitive Line rat. Acta Neuropsychiatrica, 31(4), 213-219. https://doi.org/10.1017/neu.2019.15

Hvilsom, A. S. T., Lillethorup, T. P., Iversen, P., Doudet, D. J., Wegener, G. & Landau, A. M. (2019). Cortical and striatal serotonin transporter binding in a genetic rat model of depression and in response to electroconvulsive stimuli. European Neuropsychopharmacology, 29(4), 493-500. https://doi.org/10.1016/j.euroneuro.2019.02.009

Howard, D. M., Adams, M. J., Clarke, T.-K., Hafferty, J. D., Gibson, J., Shirali, M., Coleman, J. R. I., Hagenaars, S. P., Ward, J., Wigmore, E. M., Alloza, C., Shen, X., Barbu, M. C., Xu, E. Y., Whalley, H. C., Marioni, R. E., Porteous, D. J., Davies, G., Deary, I. J. ... 23andMe Research Team (2019). Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nature Neuroscience, 22(3), 343-352. https://doi.org/10.1038/s41593-018-0326-7

Herzog, D., Wegener, G., Lieb, K., Müller, M. & Treccani, G. (2019). Decoding the Mechanism of Action of Rapid-Acting Antidepressant Treatment Strategies: Does Gender Matter? International Journal of Molecular Sciences (Online), 20(4), Article 949. https://doi.org/10.3390/ijms20040949

Glud, A. N., Jakobsen, S., Landau, A., Alstrup, A. K. O. & Sorensen, J. C. (2019). Visualization of intrathecal delivery by PET-imaging. Journal of Neuroscience Methods, 317, 45-48. https://doi.org/10.1016/j.jneumeth.2019.02.003

Gaspar, H. A., Gerring, Z., Hübel, C., Middeldorp, C. M., Derks, E. M., Breen, G. & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2019). Using genetic drug-target networks to develop new drug hypotheses for major depressive disorder. Translational Psychiatry, 9(1), Article 117. https://doi.org/10.1038/s41398-019-0451-4

Displaying results 1 to 50 out of 63

Revised 11.09.2025

Karen Jul Madsen