Equipment
• Ai4R Beaquant Real-Time Autoradiography
• https://www.ai4r.com/real-time-autoradiography/beaquant/
• Department of Nuclear Medicine and PET Center at Aarhus University Hospital
Through close and longstanding collaboration with the Department of Nuclear Medicine and PET Center at Aarhus University Hospital, we are conducting radioligand binding studies.
The equipment can be found at the PET Preclinical Facility at Aarhus University Hospital
• Enables high-performance, real-time digital autoradiography for rapid and accurate imaging of radiolabeled samples
• Offers high resolution (down to 20 µm), shorter exposure times than traditional autoradiography methods, and enhanced sensitivity- ideal for research involving low radioactivity levels
• Capable of imaging alpha and beta particles simultaneously
• A wide range of 3H-labeled ligands targeting molecular targets is commercially available, supporting diverse investigations without the need for an on-site cyclotron or specialised radiochemistry expertise
• Ai4R Beaquant Real-Time Autoradiography
• https://www.ai4r.com/real-time-autoradiography/beaquant/
• Department of Nuclear Medicine and PET Center at Aarhus University Hospital
• Visualising and quantifying the distribution of radiolabeled compounds in fresh-frozen brain tissue
• Investigating of the localization and binding of neurotransmitters, receptors, and other molecular targets
• Assessing brain function, mapping disease progression, and evaluating the effects of potential therapies
• Supporting drug discovery by enabling the evaluation of drug-target interactions and pharmacokinetics of novel compounds
1: Krogsbaek M, Larsen NY, Yarmahmoudi F, Søndergaard J, Landau AM, Sanchez C, Nyengaard JR. Chronic olanzapine treatment leads to increased opioid receptor expression and changes in feeding regulating neurons in the female rat hypothalamus. Psychoneuroendocrinology. 2025 Jan;171:107225. doi: 10.1016/j.psyneuen.2024.107225.
2: Bærentzen SL, Thomsen MB, Alstrup AK, Wegener G, Brooks DJ, Winterdahl M, Landau AM. Excessive sucrose consumption reduces synaptic density and increases cannabinoid receptors in Göttingen minipigs. Neuropharmacology. 2024 Sep 15;256:110018. doi: 10.1016/j.neuropharm.2024.110018.
3: Kjærgaard K, Daugaard Mikkelsen AC, Landau AM, Eriksen PL, Hamilton-Dutoit S, Magnusson NE, Thomsen MB, Chen F, Vilstrup H, Mookerjee RP, Bay-Richter C, Thomsen KL. Cognitive dysfunction in early experimental metabolic dysfunction- associated steatotic liver disease is associated with systemic inflammation and neuroinflammation. JHEP Rep. 2023 Dec 21;6(3):100992. doi: 10.1016/j.jhepr.2023.100992.
4: Rossi R, Bærentzen SL, Thomsen MB, Real CC, Wegener G, Grassi-Oliveira R, Gjedde A, Landau AM. A single dose of cocaine raises SV2A density in hippocampus of adolescent rats. Acta Neuropsychiatr. 2024 Apr;36(2):109-117. doi: 10.1017/neu.2023.14.
5: Binda KH, Lillethorup TP, Real CC, Bærentzen SL, Nielsen MN, Orlowski D, Brooks DJ, Chacur M, Landau AM. Exercise protects synaptic density in a rat model of Parkinson's disease. Exp Neurol. 2021 Aug;342:113741. doi: 10.1016/j.expneurol.2021.113741.
