Publications from TNU
Metaxas, A., Anzalone, M., Vaitheeswaran, R., Petersen, S., Landau, A. M. & Finsen, B. (2019). Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease. Alzheimer's Research & Therapy, 11(1), Article 38. https://doi.org/10.1186/s13195-019-0491-2
Musazzi, L., Sala, N., Tornese, P., Gallivanone, F., Belloli, S., Conte, A., Di Grigoli, G., Chen, F., Ikinci, A., Treccani, G., Bazzini, C., Castiglioni, I., Nyengaard, J. R., Wegener, G., Moresco, R. M. & Popoli, M. (2019). Acute Inescapable Stress Rapidly Increases Synaptic Energy Metabolism in Prefrontal Cortex and Alters Working Memory Performance. Cerebral Cortex, 29(12), 4948–4957. https://doi.org/10.1093/cercor/bhz034
Normann, C. & Buttenschøn, H. N. (2019). Gene-environment interactions between HPA-axis genes and stressful life events in depression: A systematic review. Acta Neuropsychiatrica, 31(4), 186-192. https://doi.org/10.1017/neu.2019.16
Pakkenberg, B., Olesen, M. V., Kaalund, S. S. & Dorph-Petersen, K.-A. (2019). Editorial: Neurostereology. Frontiers in Neuroanatomy, 13, Article 42. https://doi.org/10.3389/fnana.2019.00042
Pakkenberg, B., Olesen, M. V., Kaalund, S. S. & Dorph-Petersen, K.-A. (Eds.) (2019). Neurostereology. Frontiers Media. Frontiers in Neuroanatomy https://doi.org/10.3389/978-2-88945-880-6
Paternoster, V., Svanborg, M., Edhager, A. V., Rajkumar, A. P., Eickhardt, E. A., Pallesen, J., Grove, J., Qvist, P., Fryland, T., Wegener, G., Nyengaard, J. R., Mors, O., Palmfeldt, J., Børglum, A. D. & Christensen, J. H. (2019). Brain proteome changes in female Brd1+/- mice unmask dendritic spine pathology and show enrichment for schizophrenia risk. Neurobiology of Disease, 124, 479-488. https://doi.org/10.1016/j.nbd.2018.12.011
Pereira, V. S., Joca, S. R. L., Harvey, B. H., Elfving, B. & Wegener, G. (2019). Esketamine and Rapastinel, but not Imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression. Acta Neuropsychiatrica, 31(5), 258-265. https://doi.org/10.1017/neu.2019.25
Pereira, V. S., Suavinha, A. C. D. R., Wegener, G. & Joca, S. R. L. (2019). Prelimbic neuronal nitric oxide synthase inhibition exerts antidepressant-like effects independently of BDNF signalling cascades. Acta Neuropsychiatrica, 31(3), 143-150. https://doi.org/10.1017/neu.2018.39
Ribeiro, D. E., Casarotto, P. C., Spiacci, A. J., Fernandes, G. G., Pinheiro, L. C., Tanus-Santos, J. E., Zangrossi, H. J., Guimarães, F. S., Joca, S. R. L. & Biojone, C. (2019). Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 93(July), 232-239. https://doi.org/10.1016/j.pnpbp.2019.04.007
Ribeiro, D. E., Müller, H. K., Elfving, B., Eskelund, A., Joca, S. & Wegener, G. (2019). Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation. Journal of Psychopharmacology, 33(11), 1436-1446. https://doi.org/10.1177/0269881119872173
Ribeiro, D. E., Roncalho, A. L., Glaser, T., Ulrich, H., Wegener, G. & Joca, S. (2019). P2X7 Receptor Signaling in Stress and Depression. International Journal of Molecular Sciences , 20(11), Article 2778. https://doi.org/10.3390/ijms20112778
Ribeiro, D. E., Casarotto, P. C., Staquini, L., Pinto E Silva, M. A., Biojone, C., Wegener, G. & Joca, S. (2019). Reduced P2X receptor levels are associated with antidepressant effect in the learned helplessness model. PeerJ, 2019(10), Article e7834. https://doi.org/10.7717/peerj.7834
Rydbirk, R., Elfving, B., Folke, J., Pakkenberg, B., Winge, K., Brudek, T. & Aznar, S. (2019). Increased prefrontal cortex interleukin-2 protein levels and shift in the peripheral T cell population in progressive supranuclear palsy patients. Scientific Reports, 9(1), Article 7781. https://doi.org/10.1038/s41598-019-44234-y
Sales, A. J., Fogaça, M. V., Sartim, A. G., Pereira, V. S., Wegener, G., Guimarães, F. S. & Joca, S. R. L. (2019). Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. Molecular Neurobiology, 56(2), 1070–1081. https://doi.org/10.1007/s12035-018-1143-4
Sartim, A. G., Brito, B. M., Gobira, P. H. & Joca, S. R. L. (2019). Attenuation of glutamatergic and nitrergic system contributes to the antidepressant-like effect induced by capsazepine in the forced swimming test. Behavioural Pharmacology, 30(1), 59-66. Article 30(1). https://doi.org/10.1097/FBP.0000000000000416
Silote, G. P., Sartim, A., Sales, A., Eskelund, A., Guimarães, F. S., Wegener, G. & Joca, S. (2019). Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms. Journal of Chemical Neuroanatomy, 98, 104-116. https://doi.org/10.1016/j.jchemneu.2019.04.006
Smith, K. L., Cunningham, J. I., Eyerman, D. J., Dean, R. L., Deaver, D. R. & Sanchez, C. (2019). Opioid system modulators buprenorphine and samidorphan alter behavior and extracellular neurotransmitter concentrations in the Wistar Kyoto rat. Neuropharmacology, 146(March), 316-326. https://doi.org/10.1016/j.neuropharm.2018.11.015
Speed, M. S., Jefsen, O. H., Børglum, A. D., Speed, D. & Østergaard, S. D. (2019). Investigating the association between body fat and depression via Mendelian randomization. Translational Psychiatry, 9(1), Article 184. https://doi.org/10.1038/s41398-019-0516-4
Speed, D., Hemani, G., Speed, M. S., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & Børglum, A. D. (2019). Investigating the causal relationship between neuroticism and depression via Mendelian Randomization. Acta Psychiatrica Scandinavica, 139(4), 395-397. https://doi.org/10.1111/acps.13009
Tillmann, S., Abildgaard, A., Winther, G. & Wegener, G. (2019). Altered fecal microbiota composition in the Flinders Sensitive Line rat model of depression. Psychopharmacology, 236(5), 1445-1457. https://doi.org/10.1007/s00213-018-5094-2
Tillmann, S., Happ, D. F., Mikkelsen, P. F., Geisel, J., Wegener, G. & Obeid, R. (2019). Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression. Behavioural Brain Research, 364, 274-280. https://doi.org/10.1016/j.bbr.2019.02.011
Tillmann, S. & Wegener, G. (2019). Probiotics reduce risk-taking behavior in the Elevated Plus Maze in the Flinders Sensitive Line rat model of depression. Behavioural Brain Research, 359, 755-762. https://doi.org/10.1016/j.bbr.2018.08.025
Tillmann, S., Skibdal, H. E., Christiansen, S. H., Gøtzsche, C. R., Hassan, M., Mathé, A. A., Wegener, G. & Woldbye, D. P. D. (2019). Sustained overexpression of neuropeptide S in the amygdala reduces anxiety-like behavior in rats. Behavioural Brain Research, 367, 28-34. https://doi.org/10.1016/j.bbr.2019.03.039
Tillmann, S. & Wegener, G. (2019). Syringe-feeding as a novel delivery method for accurate individual dosing of probiotics in rats. Beneficial Microbes, 9(2), 311-315. https://doi.org/10.3920/BM2017.0127
Tornese, P., Sala, N., Bonini, D., Bonifacino, T., La Via, L., Milanese, M., Treccani, G., Seguini, M., Ieraci, A., Mingardi, J., Nyengaard, J. R., Calza, S., Bonanno, G., Wegener, G., Barbon, A., Popoli, M. & Musazzi, L. (2019). Chronic mild stress induces anhedonic behavior and changes in glutamate release, BDNF trafficking and dendrite morphology only in stress vulnerable rats. The rapid restorative action of ketamine. Neurobiology of Stress, 10, Article 100160. https://doi.org/10.1016/j.ynstr.2019.100160
Treccani, G. (2019). From Structure to Behavior: Circuit Specificity of Stress-Induced Synaptic Plasticity in the Basolateral Amygdala Projection Neurons. Biological Psychiatry, 85(3), E7-E9. https://doi.org/10.1016/j.biopsych.2018.11.017
Treccani, G., Ardalan, M., Chen, F., Musazzi, L., Popoli, M., Wegener, G., Nyengaard, J. R. & Müller, H. K. (2019). S-Ketamine Reverses Hippocampal Dendritic Spine Deficits in Flinders Sensitive Line Rats Within 1 h of Administration. Molecular Neurobiology, 56(11), 7368-7379. https://doi.org/10.1007/s12035-019-1613-3
Winterdahl, M., Noer, O., Orlowski, D., Schacht, A. C., Jakobsen, S., Alstrup, A. K. O., Gjedde, A. & Landau, A. (2019). Sucrose intake lowers μ-opioid and dopamine D2/3 receptor availability in porcine brain. Scientific Reports, 9(1), Article 16918. https://doi.org/10.1038/s41598-019-53430-9
Winther, G., Eskelund, A., Richter, C. B., Elfving, B., Müller, H. K., Lund, S. & Wegener, G. (2019). Grandmaternal High-fat Diet Primed Anxiety-like Behaviour in the Second-Generation Female Offspring. Behavioural Brain Research, 359, 47-55. https://doi.org/10.1016/j.bbr.2018.10.017
Witt, N. A., Lee, B., Ghent, K., Zhang, W. Q., Pehrson, A. L., Sánchez, C. & Gould, G. G. (2019). Vortioxetine Reduces Marble Burying but Only Transiently Enhances Social Interaction Preference in Adult Male BTBR T+Itpr3tf/J Mice. ACS Chemical Neuroscience, 10(10), 4319-4327. https://doi.org/10.1021/acschemneuro.9b00386
Zhang, X., Abdellaoui, A., Rucker, J., de Jong, S., Potash, J. B., Weissman, M. M., Shi, J., Knowles, J. A., Pato, C., Pato, M., Sobell, J., Smit, J. H., Hottenga, J. J., de Geus, E. J. C., Lewis, C. M., Buttenschøn, H. N., Craddock, N., Jones, I., Jones, L. ... Levinson, D. F. (2019). Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts. Biological Psychiatry, 85(12), 1065-1073. https://doi.org/10.1016/j.biopsych.2019.02.022
Abildgaard, A., Elfving, B., Müller, H. K., Hokland, M., Lund, S. & Wegener, G. (2018). Probiotics - a novel antidepressant? Lessons from preclinical studies. 11-12. Abstract from SCNP 59th Annual Meeting 2018, Aarhus, Denmark.
Abildgaard, A., Elfving, B., Hokland, M., Wegener, G. & Lund, S. (2018). The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour. Archives of Physiology and Biochemistry, 124(4), 306 – 312. https://doi.org/10.1080/13813455.2017.1398262
Al-Absi, A. R., Christensen, H. S., Sanchez, C. & Nyengaard, J. R. (2018). Evaluation of semi-automatic 3D reconstruction for studying geometry of dendritic spines. Journal of Chemical Neuroanatomy, 94, 119-124. https://doi.org/10.1016/j.jchemneu.2018.10.008
Alstrup, A. K. O., Munk, O. L., Landau, A. M. & Lillethorup, T. P. (2018). PET radioligand injection for pig neuroimaging. Scandinavian Journal of Laboratory Animal Science, 44(2), 1-5.
Anzabi, M., Ardalan, M., Iversen, N. K., H. Rafati, A., Hansen, B. & Østergaard, L. (2018). Hippocampal Atrophy Following Subarachnoid Hemorrhage Correlates with Disruption of Astrocyte Morphology and Capillary Coverage by AQP4. Frontiers in Cellular Neuroscience, 12(19), Article 19. https://doi.org/10.3389/fncel.2018.00019
Generation Scotland & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2018). Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. PLoS One, 13(12), Article e0209160. https://doi.org/10.1371/journal.pone.0209160
Bak, S. T., Staunstrup, N. H., Starnawska, A., Daugaard, T. F., Nyengaard, J. R., Nyegaard, M., Børglum, A., Mors, O., Dorph-Petersen, K.-A. & Nielsen, A. L. (2018). Evaluating the Feasibility of DNA Methylation Analyses Using Long-Term Archived Brain Formalin-Fixed Paraffin-Embedded Samples. Molecular Neurobiology, 55(1), 668-681. https://doi.org/10.1007/s12035-016-0345-x
Bannach-Brown, A., Przybyła, P., Thomas, J., Rice, A. S. C., Ananiadou, S., Liao, J. & Macleod, M. R. (2018). Machine learning algorithms for systematic reviews: reducing workload in a preclinical review of animal studies and reducing human screening error. bioRxiv. http://biorxiv.org/content/early/2018/10/30/255760.abstract
Bay, V., Kjølby, B. F., Iversen, N. K., Mikkelsen, I. K., Ardalan, M., Nyengaard, J. R., Jespersen, S. N., Drasbek, K. R., Østergaard, L. & Hansen, B. (2018). Stroke infarct volume estimation in fixed tissue: Comparison of diffusion kurtosis imaging to diffusion weighted imaging and histology in a rodent MCAO model. PLoS One, 13(4), e0196161. Article e0196161. https://doi.org/10.1371/journal.pone.0196161
Bertelsen, F., Landau, A. M., Vase, K. H., Jacobsen, J., Scheel-Krüger, J. & Møller, A. (2018). Acute in vivo effect of valproic acid on the GABAergic system in rat brain: A [C-11]Ro15-4513 microPET study. Brain Research, 1680, 110-114. https://doi.org/10.1016/j.brainres.2017.12.018
Brown, E., Mc Veigh, C. J., Santos, L., Gogarty, M., Müller, H. K., Elfving, B., Brayden, D. J. & Haase, J. (2018). TNFα-dependent anhedonia and upregulation of hippocampal serotonin transporter activity in a mouse model of collagen-induced arthritis. Neuropharmacology, 137, 211-220. https://doi.org/10.1016/j.neuropharm.2018.04.023
Buttenschøn, H. N., Elfving, B., Nielsen, M., Skeldal, S., Kaas, M., Mors, O. & Glerup, S. (2018). Exploring the sortilin related receptor, SorLA, in depression. Journal of Affective Disorders, 232, 260-267. https://doi.org/10.1016/j.jad.2018.02.050
Buttenschøn, H. N., Nielsen, M., Glerup, S. & Mors, O. (2018). Investigation of serum levels of sortilin in response to antidepressant treatment. Acta Neuropsychiatrica, 30(2), 111-116. https://doi.org/10.1017/neu.2017.13
Chen, F., Danladi, J., Ardalan, M., Elfving, B., Müller, H. K., Wegener, G., Sanchez, C. & Nyengaard, J. R. (2018). A critical role of mitochondria in BDNF-associated synaptic plasticity after one-week vortioxetine treatment. International Journal of Neuropsychopharmacology, 21(6), 603-615. https://doi.org/10.1093/ijnp/pyy022
Chen, F., Ardalan, M., Elfving, B., Wegener, G., M Madsen, T. & Nyengaard, J. R. (2018). Mitochondria are critical for BDNF-mediated Synaptic and Vascular plasticity of Hippocampus following Repeated Electroconvulsive Seizures. International Journal of Neuropsychopharmacology, 21(3), 291-304. https://doi.org/10.1093/ijnp/pyx115
Christensen, K. & Bertelsen, A. (2018). Irving I. Gottesman's Collaboration in Psychiatric Genetics Research in Denmark. Twin Research and Human Genetics, 21(4), 322-323. https://doi.org/10.1017/thg.2018.32
Czeh, B., Vardya, I., Varga, Z., Febbraro, F., Csabai, D., Martis, L.-S., Højgaard, K., Henningsen, K., Bouzinova, E., Miseta, A., Jensen, K. & Wiborg, O. (2018). Long-Term Stress Disrupts the Structural and Functional Integrity of GABAergic Neuronal Networks in the Medial Prefrontal Cortex of Rats. Frontiers in Cellular Neuroscience, 12, Article 148. https://doi.org/10.3389/fncel.2018.00148
